Remeron - powerful anti-catabolic?

[Bakgat]

Remeron (mirtazapine) from Organon is a new-age anti-depressant that comes in 15mg and 30mg tablets.

Remeron is widely reported to have shown to have an acute inhibiting effect on cortisol secretion in healthy subjects. Apparently, mirtazapine rapidly attenuates HPA axis hyperactivity via direct pharmaco-endocrinological effects.

See the following link for the evidence: http://www.biopsychiatry.com/mirtazremeron.htm

Does the data reflected in the above link suggest Remeron could function as an effective anti-catabolic? Furthermore, has anyone used Remeron effectively for this purpose?

 

[junk]

bump!

 

[Bakgat]

BUMP

Is this something that could further tilt the anabolic vs catabolic equation in our favour or am I barking up the wrong tree?... anyone?

 

[40butpumpin]

interesting to me too, is this stuff available in the US? anyone?

 

[Bakgat]

I think Remeron only hit the market in 1997. It is certainly available in my country. I would assume it is also available in the US.

 

[test-monkey]

this would be good for post-cycle lowering cortisol while fighting depression

 

[argent]

Is it any different tahn cytadren?

 

[Ulter]

The only problem I have with it is the number of people who get sides from it. The percentage 20% is just way too high for me to recommend it to someone coming off a cycle. Hormonal imbalances have you messed up enough. There was one study that one out of every 4 people dropped out because of anxiety, nausia, etc.
BUT, that said, some people I trust literally with my life at times are forming a consensus of authors, board owners, chemists, and veterans that will be posted on the POST CYCLE VETERANS CONSENSUS STATEMENT at Anabolic Fitness after the Holidays if anyone is interested.

 

[DrJMW]

Have had good success with Remeron. Seems safer than Cytadren.

 

[jpjay13]

Remeron (mertazapine) went generic in around '97 (but its still a/b $2/pill in the US).
It'll make you tired and hungry as hell though due to its antihistaminic properties.
At higher doses (+45mg/day) it stimulates the release of dopamine which can counteract the sedative qualities.
it shouldn't cause any anxiety at all, in fact its often used as an anxiolytic. If anxiety showed up as a side its more likely because its being studied in depressed pats where anxiety is just a comorbidity. Its very safe though and healthy people who eat normally shouldn't have any nausea or GI problems.
Honestly though, its probably too sedating to be effectively used for bodybuilders. If, as the study implies, antagonism of the presynaptic Alpha 1 or 2 receptors has anything to do with decreased cortisol secretion you might want to look at Venlafaxine (Effexor) as an alternative. (supposed to me even more stimulating than mertazapine and is not sedating)

just my thoughts.

 

[DrJMW]

Remeron may be most effective post-cycle to prevent cortisol increases.

 

[Huck Fedd]

so if you have a hard time sleeping after your early evening workout..then perhaps this is due to post-exercise induced trauma causing a cortisol spike..remeron can cure this?..possibly good for night time carb cravings as well

 

[b1ewsw32]

so if you have a hard time sleeping after your early evening workout..then perhaps this is due to post-exercise induced trauma causing a cortisol spike..remeron can cure this?..possibly good for night time carb cravings as well

Not possibly Huck Fed...100% guaranteed for night time refrigerator eating contests.
This drug is notorious for it's coma like sleepiness and daytime groginess/lethargy and it will want to make you eat everything in sight, all the time probably due to it's antagonism at the histaminergic receptors ie. antihistamine.

B32

 

[junk]

Remeron may be most effective post-cycle to prevent cortisol increases.

Interesting!
I'm starting my PCT in a few days and I thought about just
including clenbuterol at 120mcg straight for 2-4 weeks to lower
cortisol levels. So do you suggest Remeron instead? Or in
addition to clen? Anyone with experiences with Remeron ?
I don't want to be a guinea pig.

 

[buckwheat1]

Interesting!
I'm starting my PCT in a few days and I thought about just
including clenbuterol at 120mcg straight for 2-4 weeks to lower
cortisol levels. So do you suggest Remeron instead? Or in
addition to clen? Anyone with experiences with Remeron ?
I don't want to be a guinea pig.

Clen does not lower cortisol levels.

 

[bicepts101]

Interesting!
I'm starting my PCT in a few days and I thought about just
including clenbuterol at 120mcg straight for 2-4 weeks to lower
cortisol levels. So do you suggest Remeron instead? Or in
addition to clen? Anyone with experiences with Remeron ?
I don't want to be a guinea pig.

yeah i wanna here from someone that has tried this

 

[BrotherMaynard]

I have a buddy that has used remeron for a long time now, it's prescribed since he suffers insomnia and depression. He gained a LOT of weight. He is my training partner, he's natural but I know that based on how hard he works in the gym he shouldn't be getting a huge gut that he has now. He blames the remeron for the weight gain. Using it briefly for post cycle sounds interesting, but just seeing how my friend reacts to this stuff I wouldn't want to be on it for very long.

 

[AZK8900]

Yes. I got back on remeron to treat insomnia along with a dianabol/test/nandrolone/arimidex cycle. I drastically cut my fat intake along with my cycle, and I've gained about 20 pounds of fat in 2.5 weeks. Stay the F**k away from remeron unless you don't mind becoming a blimp. Also, I've read that the real way remeron adds fat is not by increasing appetite, but by massively increasing the amount of free leptin in the bloodstream, and putting fat on you regardless of what you eat or how much you exercise. That's probably why it's prescribed to anorexics and bulimics.

 

[Jaxtwo1]

Been on it twice in my lifetime. Saved my life.