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Prolactin normal so why gyno?

Spidey

New member
I had a thread a week or two ago explaining that I am showing gyno symptoms (lumps, tenderness, etc.) and some people seemed to think that the tren in my cycle (which ended 8-10 weeks before) may have caused it.

I went and had my prolactin levels checked and they came back in the normal range: 4.75 ng/mL (normal is 2.75 ng/mL - 13.3 ng/mL for men).

My test levels were also normal so my estrogen levels are likely to be normal as well so WHY THE GYNO?

Nolvadex seems to be helping as I am much less tender. Bromo probably won't do anything since my prolactin levels are normal, right?

What do you guys think I should do here? Just continue the nolva? Add in bromo?

-Spidey
 
Don't know my progestin levels but I have been off the tren for 10 or 11 weeks now. I think it may be the HGH I am taking that is causing the gyno (due to elevated IGF1). If that is the case, do you think bromo will help?

-Spidey
 
Quit focusing on prolactin. It can't cause gyno except by depressing test levels. Prolactin is not your problem. The IGF-1 most likely is.

IGF-1 acts in concert with estrogen to cause gyno. Your best bet (other than quitting the GH) is to block the estrogen with nolvadex, the tried and true gyno treatment. You could add some andractim or the chinese knockoff (which works) as well.

Bromocriptine will do nothing for you.



www.cuttingedgemuscle.com
 
nandi12 said:
Prolactin is not your problem. The IGF-1 most likely is.

IGF-1 acts in concert with estrogen to cause gyno. Your best bet (other than quitting the GH) is to block the estrogen with nolvadex, the tried and true gyno treatment.

this, in part, MAY be correct. lowering IGF-1 is often effective, it is the basis for most breast cancer treatments. Use of femara would also be effective- it is a strong aromatase inhbitor- slightly elevated estrogen can mean higher IGF-1.

with respect to prolactin a normal reading does NOT mean that it is not a problem.. prolactin spikes, typically at night- when both GH and prolactin surge- might be the issue. bromo may be effective

are you taking any orals? these typically elevate IGF-1 as well.
 
macrophage69alpha said:

with respect to prolactin a normal reading does NOT mean that it is not a problem.. prolactin spikes, typically at night- when both GH and prolactin surge- might be the issue. bromo may be effective
This prolactin surge idea is interesting. Why does it surge at night? Could you give me a reference?

macrophage69alpha said:
are you taking any orals? these typically elevate IGF-1 as well.
No, I'm not on anything right now other than GH at 4 iu's ed. I have been taking GH for about 5 weeks now. The gyno started at around 3.5 to 4 weeks.

So, GH raises IGF1 and Noladex lowers IGF1. By taking 40 mg nolva ed, am I totally negating any benefit I might get from GH? Would taking a aromatase inhibitor be as effective at treating the gyno without lowering IGF1 as much?

-Spidey
 
1. quit taking the GH
2. exogenous gh affect prolactin-

interesting study

Endocrinology 1999 Sep;140(9):3909-18 Related Articles, Links


The 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the effect on the human prolactin receptor.

Tsunekawa B, Wada M, Ikeda M, Uchida H, Naito N, Honjo M.

Life Sciences Laboratory, Performance Materials R&D Center, Mitsui Chemicals, Inc., Chiba, Japan.

Previously we have demonstrated that 20-kDa human GH (20K-hGH) is a full agonist for hGH receptor (hGHR) even though its complex formation with hGHR and hGH-binding protein differs from that of 22-kDa human GH (22K-hGH). In this study, we focused on the effect of 20K-hGH on human PRL receptor (hPRLR). To elucidate the effects of 20K-hGH on hPRLR and compare them with those of 22K-hGH, we prepared two cells stably expressing full-length hPRLR, Ba/F3-hPRLR and CHO-hPRLR. In the proliferation of Ba/F3-hPRLR cells, which can grow in a dose-response to lactogenic hormones, both 20K- and 22K-hGH exhibited bell-shaped curves in the absence of exogenous zinc ion (Zn2+); however, the curve of 20K-hGH was shifted to a 10-fold higher concentration than that of 22K-hGH in view of EC50 value (the EC50 of 20K- and 22K-hGH were 15 nM and 1.5 nM, respectively). Addition of Zn2+ up to 25 microM increased the activities of both 20K- and 22K-hGH; however, the enhancement by Zn2+ was greater in 20K-hGH than in 22K-hGH, thereby the activities of both hGH isoforms reached the same level at 25 microM Zn2+. Nevertheless, in the presence of 0.25-1 microM free Zn2+, which is equal in human serum, the activity of 20K-hGH was still lower than that of 22K-hGH. The modest effect of 20K-hGH on activating hPRLR in the absence of Zn2+ was confirmed in the rat serine protease inhibitor 2.1 (Spi2.1) gene promoter activation and JAK2/Stat5 tyrosine phosphorylation in CHO-hPRLR. In addition, in human breast cancer cell T-47D, 20K-hGH was proved to stimulate Stat5 tyrosine phosphorylation to much lower degree than 22K-hGH via not hGHR but hPRLR. Taken together, our data suggest that 20K-hGH may be a weaker agonist for hPRLR than 22K-hGH in the human body; therefore 20K-hGH may alleviate the hPRLR-mediated side-effects such as breast cancer when administered to human body.
 
macrophage69alpha said:
1. quit taking the GH
I was afraid you'd say that:( . I had hoped I could take GH to help my biceps tendon that has flattened. I don't know of anything else I could take to help that. I lucked out and got a hold of some humatrope from a close friend. I could never have afforded to buy it.

The Nolva at 40 mg ed seems to be helping. The sensitivity has gone down quite a bit. Do you think I can get away with taking Nolva 40 mg ed and continuing the GH at 4 iu's ed? How about lowering my GH dose to 2 iu's ed?

I really hate to give up on it so soon after starting. I really need to find some way of stopping/reversing the degradation of my biceps tendons before the just pop one day.

-Spidey
 
you might consider adding low dose bromo 1/4 tab eod.. this should be sufficient to lower your prolactin and inhibit "spiking"..

prolactin issues may also be a result of the inconsistent presence of HGH.


clipped :p
""Prolactin has a synergistic action with estrogen to promote mammary gland proliferation. It also brings about the release of progesterone from lutein cells which renders the uterine mucosa suitable for the imbedding of the ovum, should fertilization occur. Growth hormone also binds the lactogenic receptor (the receptor to with prolactin binds) but is not a significant source of lactation stimulation at normal physiological levels. Excessive levels of growth hormone, however, may lead to galactorrhea. This is analogous to high levels of prolactin binding to growth hormone receptor and inducing acromegaly.

Take home message: at high levels, prolactin and growth hormone can bind to one anothers receptors! ""
 
Thanks Macro. I have a line on some bromo. I'll start that at 1/4 tab eod and see what happens. I tried to give you karma (like you need it, LOL) but it tells me I have to spread it around first.

-Spidey
 
So a guy says to his friend; 'I really wish I could quit smoking." His friend replies; Why can't you?' To which the first guy responds; "I don't want to."

I'll let you figure out the analogy.

GH increases IGF_1 So you're going to take Nolvadex to counteract the IGF-1. Call me crazy, but wouldn't it make more sense to stop the GH?

Besides, it sounds like progesterone enduced gyno.
 
GH increases IGF_1 So you're going to take Nolvadex to counteract the IGF-1


No, the nolvadex is intended to block estrogen. IGF-1 alone won't cause gyno or even stimulate growth of any kind of mammary tissue. Estrogen is the key ingredient to breast development as well as gyno. This is why nolvadex has always been the treatment of choice for gyno. Blocking progesterone and prolactin may or may not have an effect. Blocking estrogen will.

Tamoxifen lowers IGF-1 by lowering endogenous GH levels, not by blocking hepatic IGF-1 production:

"In the normal men, tamoxifen significantly reduced 24-h mean serum GH (1.1 +/- 0.3 to 0.5 +/- 0.1 micrograms/L, P < 0.05), mean GH pulse amplitude (8.4 +/- 1.7 to 4.7 +/- 0.4 micrograms/L, P < 0.05), and serum IGF-I (1.0 +/- 0.1 to 0.7 +/- 0.1 U/mL, P < 0.001)." (1)

So when you are taking exogenous GH, the tamoxifen will have no effect on IGF-1 levels, but it will block the estrogen receptor which is essential for gyno development. (Estrogen receptor knockout mice do not develop mammary tissue no matter how much estrogen or IGF-1 they are given.)

Aromatase inhibitors on the other hand do block hepatic IGF-1 production with no effect on GH levels. So you would not want to take arimidex with your GH. Use tamoxifen instead. And of course a doctor would tell you to:

a) quit the GH
b) start a course of Nolvadex to treat the existing gyno



(1) J Clin Endocrinol Metab 1993 Jun;76(6):1407-12

Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization.

Weissberger AJ, Ho KK.


www.cuttingedgemuscle.com
 
Nelson Montana said:
So a guy says to his friend; 'I really wish I could quit smoking." His friend replies; Why can't you?' To which the first guy responds; "I don't want to."

I'll let you figure out the analogy.

GH increases IGF_1 So you're going to take Nolvadex to counteract the IGF-1. Call me crazy, but wouldn't it make more sense to stop the GH?

Besides, it sounds like progesterone enduced gyno.
Nelson, why are you so damn sarcastic and condescending all the time? I am not a child or an idiot so please don't talk to me as such. Do you know of some alternative therapy to strengthen my degenerated and flattened biceps tendons? If you do, please enlighten me. If I can't find some fix for those, I may have to stop lifting alltogether or risk rupturing both of them. I see GH as my last chance to continue lifting so I am understandably reluctant to give it up at the first sign of trouble.

As for progesterone gyno, I don't think so. I did develop some tenderness while on cycle (no lumps though) but that totally went away within days of ending my cycle. I had no gyno symptoms of any kind until about 3.5 to 4 weeks after starting GH at 4 iu's ed. The lumps are hard (consistent with estrogen gyno) not soft like would be expected from progesterone gyno. Also, Nolvadex (an estrogen blocker, NOT a progesterone blocker) at 20 mg ed (bumped up to 40 mg ed two days ago) is definately reducing the symptoms. Finally, I had my prolactin levels measured and they are normal. If my progestin levels were high, wouldn't my prolactin levels be high as well? The two kind of follow each other don't they?

I know Zyglamail likes prolotherapy but, truthfully, that sounds like a lot of huey to me. My shoulders have been chronically inflamed for 10 frickin years; how is an induced inflamation like prolo going to help heal them?

I have stopped the GH for now and will continue the nolva untill the gyno is gone. After that, I don't know. I am a little depressed about the whole thing. I may start it again at 2 iu's ed with 20 mg ed nolva and see iff symptoms reappear. If they do, I guess I'm done with lifting. I am not going to risk rupturing my biceps tendons.

-Spidey
 
nandi: I appreciate what you're trying to do bro but that's essentially a round-about, technical explanation of saying the same thing I said.

Spidey: I don't mean to make light of your ailment. What you're calling sarcasim is just my way of being glib.

Your approach is indicitive of many of the people who frequent this board. You make an assumption, look for a drug to alleviate the problem, and then look for another drug to alleviate the problems the first drug gave you. Meanwhile, you still have the first problem.

I can not diagnose your flattened bicep, but I'm also not sure if GH is the answer. It may make it worse.

You also said your estrogen is normal yet you feel an estrogen blocker is the answer. (?) My assumption that the gyno was prog related was because you said you did tren.

Prog and prolactin don't necessarily elevate corespondingly. Excess Prolactin in men is very rare anyway.

What a lot of people don't realize is that gyno sometimes subsides by itself -- it may have nothing to do with the Nolvadex. Besides, if it's from elevated estrogen during your cycle, you're closing the barn door after the horse ran away.

The bottom line here; stop fucking yourself up further wih guesswork. And don't indiscriminately start taking more drugs on the advice of strangers on a message board.
I'm as sceptical of doctors as anyone, but if your condition is as serious as you make it out to be, you better get your ass to one. Then get a second opinion, and a third, and a forth. Talk to a surgeon. And an accupunturist. And someone who deals in A.R.T. And a physical therepist. Experiment with working aound your injury. Try different angles -- lighter weights with less rest in-between sets. Shorter movements. There's a lot you can do without making it a choice between taking a closetful of drugs or giving up.

Best of luck.
 
I appreciate what you're trying to do bro but that's essentially a round-about, technical explanation of saying the same thing I said.


No, actually Nelson you missed the point completely. Look at your remark:

"GH increases IGF_1 So you're going to take Nolvadex to counteract the IGF-1."

The Nolva is not intended to block the IGF-1 but rather the estrogen that is causing the gyno along with the exogenous GH. Eliminate either one and you break the chain. If he wants to continue on GH, then nolva is the best option. If he wants to quit the GH and take nolva, that as is I said would be the most sound medical advice.
 
Nelson Montana said:
nandi: I appreciate what you're trying to do bro but that's essentially a round-about, technical explanation of saying the same thing I said.

Spidey: I don't mean to make light of your ailment. What you're calling sarcasim is just my way of being glib.

Your approach is indicitive of many of the people who frequent this board. You make an assumption, look for a drug to alleviate the problem, and then look for another drug to alleviate the problems the first drug gave you. Meanwhile, you still have the first problem.

I can not diagnose your flattened bicep, but I'm also not sure if GH is the answer. It may make it worse.

You also said your estrogen is normal yet you feel an estrogen blocker is the answer. (?) My assumption that the gyno was prog related was because you said you did tren.

Prog and prolactin don't necessarily elevate corespondingly. Excess Prolactin in men is very rare anyway.

What a lot of people don't realize is that gyno sometimes subsides by itself -- it may have nothing to do with the Nolvadex. Besides, if it's from elevated estrogen during your cycle, you're closing the barn door after the horse ran away.

The bottom line here; stop fucking yourself up further wih guesswork. And don't indiscriminately start taking more drugs on the advice of strangers on a message board.
I'm as sceptical of doctors as anyone, but if your condition is as serious as you make it out to be, you better get your ass to one. Then get a second opinion, and a third, and a forth. Talk to a surgeon. And an accupunturist. And someone who deals in A.R.T. And a physical therepist. Experiment with working aound your injury. Try different angles -- lighter weights with less rest in-between sets. Shorter movements. There's a lot you can do without making it a choice between taking a closetful of drugs or giving up.

Best of luck.
I am a little touchy about this whole thing:p . I don't mean to attack anyone.

I will try to more clearly explain. I have had chronic shoulder problems for the last 10 years. It is usually asymptomatic until I overdo it somehow. When I do overdo it, I am in intense and constant pain for a minimum of three to four weeks. Mega doses of antiinflammatories don't touch it. I finally went and got an MRI and apparently my biceps tendon (where it attaches to the labrum in my shoulder) has significantly flattened, which the doctor tells me is evidence of some degeneration of the tendon itself. He believes that this is the cause of my pain.

I had hoped to stabilize my shoulder by building up the muscles around it. That was why I even considered steroids in the first place; I couldn't do that naturally for two reasons. First, I am a natural ectomorph that finds it nearly impossible to gain any weight and second, I couldn't get into the gym for more than a few days or a week before my shoulders would inflame and force me to quit. I needed results quickly as well as the enhanced recovery times that come from steroids.

I did my first cycle and gained a solid 25 pounds with no lasting sides. NO GYNO. I was elated; alas, my elation was short lived. Just two weeks after finishing my cycle and a day after finishing up my clomid therapy, my shoulders decided to do their thing and this time, it took six weeks and dozens of physical therapy visits for the pain to subside.

The orthopedist had nothing to offer me, except as a last resort, surgery. They would cut the tendon at the labrum and remove about 5 to 6 inches off the top and then reattach the tendon to my humerus. This would change the entire dynamics of my arm and shoulder, forever prohibiting a normal range of movement. Needless to say, I'm not too excited about that option. I have read about GH strengthening and thickening tendons and thought I would try it since I have nothing to lose (it certainly won't weaken them). I thought I had done my research but somehow I missed the possibility of GH induced gyno.

OK, with that background, I will address your post above:

First, I never said my estrogen levels were normal. Truthfully, I haven't had my estrogen levels even checked. I had my test levels checked and they were squarely in the middle of the normal range. Since, estradiol only has a 60 to 90 minute half life, and we get all of our estrogen from aromatization of test, estradiol levels are likely to closely correspond to test levels. Since my test levels are normal, I assume my estrogen levels should be normal as well. BUT THAT IS AN ASSUMPTION ON MY PART.

Second, GH increases IGF1. Elevated IGF1 can cause gyno in the presence of estrogen, perhaps even normal levels of estrogen. It does REQUIRE estrogen however. If I block my estrogen receptors, IGF1 shouldn't be able to cause gyno.

I have stopped taking the GH for now as Nandi suggested. If My gyno disappears and I take GH again and it comes back, are you still going to believe it was the tren's fault? Remember, I had no gyno symptoms of any kind until after I took GH for about 4 weeks.

Like I said, If you know any way to strengthen tendons, I am open to suggestion. My doctors don't know one.

-Spidey
 
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