agree how can u prove its helps minimise shutdown?
thats a pretty BIG claim to make without evidence
The product its self "hcgenerate" has not been tested ina clinical study no. I am not rich lol so cant afford that. However the ingredents in the product have all been tested for many different functions. Read for your self!!!!!!!!!!
I am going to say this. I will list just "Fadogia" on my label and I am fine to do that. Because well what is in the product is "Fadogia" and no one can say otherwise. However I do not use the whole plant just an extract thereof . Still "Fadogia" though. Anyway if you read the studies you will maybe understand a few things.
http://www.superhumanradio.com/research/Asian J Androl 2005 Fadogia agrestis.pdf
Abstract
Aim: To evaluate the phytochemical constituents and the aphrodisiac potential of the aqueous extract of Fadogia agrestis (Rubiaceae) stem in male albino rats. Methods: The aqueous stem extract of the plant was screened for phytochemical constituents. Male rats were orally dosed with 18 mg/kg, 50 mg/kg and 100 mg/kg body weight, respectively, of the extract at 24 h intervals and their sexual behavior parameters and serum testosterone concentration were evaluated at days 1, 3 and 5. Results: Phytochemical screening revealed the presence of alkaloids and saponins while anthraquinones and flavonoids are weakly present. All the doses resulted in significant increase in mount frequency, intromission frequency and significantly prolonged the ejaculatory latency (P< 0.05) and reduced mount and intromission latency (P < 0.05). There was also a significant increase in serum testosterone concentrations in all the groups in a manner suggestive of dose-dependence (P < 0.05). Conclusion: The aqueous extract of Fadogia agrestis stem increased the blood testosterone concentrations and this may be the mechanism responsible for its aphrodisiac effects and various masculine behaviors. It may be used to modify impaired sexual functions in animals, especially those arising from hypotestosteronemia. (Asian J Androl 2005 Dec; 7: 399-404)
Already we see some promising stuff here. But lets keep reading, and move along to 2.2 in the study
2.2 Plant authentication, preparation of plant extract and phytochemical analysis
The plant sample bought from the herb sellers at Kulende Market, Ilorin, Nigeria was authenticated at the Department of Horticulture and Landscape Technology, Federal School of Forestry, Jos, Nigeria with a voucher number 2:108. The plant stem was cut into pieces, oven-dried at 40 °C to a constant weight. The dried pieces were then pulverized using an electric blender (Blender/Miller III, model MS-223, Taiwan, China) and the powder obtained was stocked in a plastic container from which varying amounts were taken and extracted in distilled water for 48 h at room temperature (26 °C-28 °C). This was then filtered using filter paper (Whatman No. 1). The filtrate was then concentrated in stem bath and the resulting brownish black residue was reconstituted in distilled water to give the equivalent dose of 18 mg/kg body weight (value originated from ethnobotanical survey), while higher doses of 50 mg/kg body weight and 100 mg/kg body weight were also used in this study. The reconstituted aqueous extract was administered orally using plastic syringes to all animals in different groups. The aqueous extract was subjected to chemical tests for the qualitative and quantitative analyses of alkaloids, tannins, phlobatannins, anthraquinones, cardiac glycosides, saponins, cardenolides and dienolides, phenolics, flavonoids, caffeine, triterpenes and steroids [7, 8].
HMMM interesting. An extraction process is explained??? Not a whole Fadogia plant like others have used in the past. But a extraction process of the stem non the less. Just Fadogia its self is not cheap. A extraction of the plat it even more expensive, and a extraction from just the stem is tripple the expensive. All I will say is I just don't think any one is going to sell that right there at 1500mg for 39 bucks and that would be even if it was just that and nothing else.
Moving on
all the way down to the discussion part of the study
Studies have implicated the saponin component of plants in enhancing aphrodisiac properties due to its androgen increasing property [6]. Saponins present in the aqueous extract of this plant might have assisted in stimulating an increase in the body natural endogenous testosterone levels by raising the level of leutinizing hormones (LH). This LH released normally by the pituitary gland helps to maintain testosterone levels; as LH increases, so does the testosterone [6]. The increase in testosterone seemed to have translated into the male sexual competence observed in this study. Furthermore, this study suggests that the aphrodisiac action may be mediated through a change in the blood testosterone level
Threw out the rest of the study we (every one smart or retarded) can clearly see that Yes Fadogia "Stem extracts" do in fact raise Serum level testosterone 3-6 and even some times up to 9 fold.
So what exactly are you arguing? You yourself have already stated that just Fadogia its self can and does raise testosterone. Also everyone (well almost everyone) can agree to that fact. So I guess the real question that you should be asking is (By what mechanism?)
Now if it is clearly used for erectile dysfunction and clearly raises free and serum level testosterone (like even you and everyone else says). Everyone reports a testicle size increase well on cycle or during pct. Look around all forums and you can see the reports from people using products with (almost Fadogia extract like ingredients ). So if it does all this then by what mechanism?
Does it work like a serum? By lowering estrogen and thus raising test in the hormone loop? Nope nothing about that in this study or any study for that matter. In fact this one can deff be ruled out.
Is it a androgen its self? Please give me a brake!!!!
So whats that leave?
Well like most plant extracts "saponin" in various potency come from them and they have been proven to stimulate and or mimic the release of luteinizing hormone (LH) from the pituitary gland!!!!!
If its not a serum, its not a androgen, it raises test levels,raises sex drive,plumps up your nuts on and off cycle (and all this by the plant its self not even the right extracts of), does not lower estrogen, all paths lead str8 to lh production!!!! This can also be seen in its action to bring back leydig cell volume!!! Which is reported by many.
Now What else happens when you administer steroids into the body?
When steroids are administered, LH levels rapidly decline. The absence of an LH signal from the pituitary causes the testes to stop producing testosterone, which causes rapid onset of testicular degeneration. The testicular degeneration begins with a reduction of leydig cell volume, and is then followed by rapid reductions in intra-testicular testosterone (ITT), peroxisomes, and Insulin-Like Growth Factor (Igf) – All important bio-markers and factors for proper testicular function and testosterone production. IGF effects many things as well as protein metabolism an others.
Many studies have shown the Zinc suplamentation can have an effect on Igf.
And we have all seen studies showing V-e's protective effect on Leydig cell steroidogenesis
ScienceDirect - Experimental Gerontology : Vitamin E, aging and Leydig cell steroidogenesis
just one pulled out of my ass
Taken together, the results of the in vitro and in vivo studies reported herein are consistent with the conclusion that vitamin E exerts a protective effect on Leydig cell steroidogenesis.
LJ100 Eurycoma longifolia extract
Study Indicates LJ100 Eurycoma longifolia extract Safely Promotes Anabolic Balance During Endurance Exercise :: News :: Natural and Nutritional Products Industry Center
About LJ 100®
LJ100® is a standardized, freeze-dried Eurycoma longifolia extract, containing 40% glycosaponins and 22% eurypeptides, a bioactive glycoprotein that is now clinically proven for its androgenic properties. LJ100® has undergone a patented BAT extraction process to capture 22% biologically active eurypeptides, proven in research to be responsible for increasing libido, improving sports performance, increasing fertility, and activating the enzymes that metabolize the various androgens.
Created by the original researchers at the Forest Research Institute of Malaysia (FRIM), University of Malaya, and Massachusetts Institute of Technology, LJ100® (22% bioactive eurypeptides) has shown - in human clinical trials - an ability to increase DHEA and free testosterone, decrease Sex Hormone Binding Globulin (SHBG), improve HDL, modulate cortisol, and increase IGF-1 level.
Now what else happens on cycle? increased shbg
Well no ones refuting the fact that 3,4 Divanillyltetrahydrofuran
has shown in multiple studies to have the highest binding affinity for SHBG of all lignans investigated thus far,lowers shbg and increases free test, and we threw in a huge dose of it.
3,4 Divanillyltetrahydrofuran
3,4-Divanillyltetrahydrofuran; A Potent Testosterone Booster
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/ )-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-) secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4 divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-) pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4 divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
3,4 Divanillyltetrahydrofuran also promote the secondary messenger nitric oxide (NO) by increasing its main enzyme eNOS (endothelial nitric oxide synthase). As NO is postulated to be one of the key triggers for muscle cell proliferation and growth while also promoting muscular pumps in the gym, this aspect of3,4 Divanillyltetrahydrofuran leads to fuller muscles that you can see and feel, thus providing significant mental motivation.
We of course added a pure Bulgarian Tribulus Terrestre wich is another widley debated Ingredent among all forums and (board vets) but many people do report great effects from it (when its pure) including an increase in sex drive. To date I have not seen a single study proving that it can raise the level srum testosterone. How ever sum studies I have come across do segest that It appears to stimulating androgen receptors in the brain. This of course will give a good lift to all around general feeling of health,well being, and mood.
Well on cycle and off Your liver does a lot of work, processing hormones,proteins and just about everything that passes threw the blood. Ferthermore Steroid use effects healthy glucose levels and healthy sugar metabolim (some more then others) this is evadent with the use of tren and also when coming off cycle.
Fenugreek PE (50% testofen)
Alcohol Alcohol. 2006 May-Jun;41(3):267-73. Epub 2006 Mar 30. Links
Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells.Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The protective effect of a polyphenolic extract of fenugreek seeds (FPEt) against ethanol (EtOH)-induced toxicity was investigated in human Chang liver cells. Cells were incubated with either 30 mM EtOH alone or together in the presence of seed extract for 24 h. Assays were performed in treated cells to evaluate the ability of seeds to prevent the toxic effects of EtOH. EtOH treatment suppressed the growth of Chang liver cells and induced cytotoxicity, oxygen radical formation and mitochondrial dysfunction. Reduced glutathione (GSH) concentration was decreased significantly (P < 0.05) while oxidized glutathione (GSSG) concentration was significantly elevated in EtOH-treated cells as compared with normal cells. Incubation of FPEt along with EtOH significantly increased cell viability in a dose-dependent manner, caused a reduction in lactate dehydrogenase leakage and normalized GSH/GSSG ratio. The extract dose-dependently reduced thiobarbituric acid reactive substances formation. Apoptosis was observed in EtOH-treated cells while FPEt reduced apoptosis by decreasing the accumulation of sub-G1 phase cells. The cytoprotective effects of FPEt were comparable with those of a positive control silymarin, a known hepatoprotective agent. The findings suggest that the polyphenolic compounds of fenugreek seeds can be considered cytoprotective during EtOH-induced liver damage.
PMID: 16574673 [PubMed - indexed for MEDLINE]
1: Pharmazie. 2007 Apr;62(4):299-304.Links
Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis.Kaviarasan S, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The present study investigates the hepatoprotective effect of fenugreek seed polyphenolic extract (FPEt) against ethanol-induced hepatic injury and apoptosis in rats. Chronic ethanol administration (6 g/kg/day x 60 days) caused liver damage that was manifested by the elevation of markers of liver dysfunction- aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and gamma-glutamyl transferase (GGT) in plasma and reduction in liver glycogen. The effects on alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were studied and found to be altered in the alcohol-treated group. Ethanol administration resulted in adaptive induction of the activities of cytochrome p450 (cyt-p-450) and cytochrome-b5 (cyt-b5) and reduction in cytochrome-c-reductase (cyt-c-red) and glutathione-S-tranferase (GST), a phase II enzyme. Further, ethanol reduced the viability of isolated hepatocytes (ex vivo) as assessed by the trypan blue exclusion test and increased hepatocyte apoptosis as assessed by propidium iodide staining (PI). Treatment with FPEt restored the levels of markers of liver injury and mitigated the alterations in alcohol metabolizing and detoxification enzymes and the electron transport component cytochrome-c reductase. Increased hepatocyte viability and reduced apoptotic nuclei were observed in FPEt-treated rats. These findings demonstrate that FPEt acts as a protective agent against ethanol-induced abnormalities in the liver. The effects of FPEt are comparable with those of a known hepatoprotective agent, silymarin.
PMID: 17484288 [PubMed - indexed for MEDLINE]
1: Cell Biol Toxicol. 2007 Apr 24 [Epub ahead of print] Links
Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver.Kaviarasan S, Viswanathan P, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India,
[email protected] This e-mail address is being protected from spambots, you need JavaScript enabled to view it .
Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.
PMID: 17453353 [PubMed - as supplied by publisher]
1: Phytother Res. 2003 Aug;17(7):737-43. Links
Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity.Thirunavukkarasu V, Anuradha CV, Viswanathan P.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The study investigates the effect of aqueous extract of fenugreek seeds (Trigonella foenum graecum) on lipid peroxidation and antioxidant status in experimental ethanol toxicity in rats. The ability of the seed extract to prevent iron-induced lipid peroxidation in vitro was also investigated. Ethanol feeding for 60 days resulted in significant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase. The levels of serum lipid hydroperoxides and thiobarbituric acid reactive substances in liver and brain were also significantly elevated. Significantly lower activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and glutathione reductase were observed in liver and brain accompanied by depletion in glutathione, ascorbic acid and alpha-tocopherol concentrations. Activity of Ca(2+) ATPase in brain was significantly lowered. Simultaneous administration of aqueous extract of fenugreek seeds with ethanol prevented the enzymatic leakage and the rise in lipid peroxidation and enhanced the antioxidant potential. The seeds exhibited appreciable antioxidant property in vitro which was comparable with that of reduced glutathione and alpha-tocopherol. Further, histopathological examination of liver and brain revealed that, aqueous extract of fenugreek seeds could offer a significant protection against ethanol toxicity. Copyright 2003 John Wiley & Sons, Ltd.
PMID: 12916070 [PubMed - indexed for MEDLINE]
healthy glucose levels and healthy sugar metabolism By assisting the pancreas in production of insulin
the active compounds 4-hydroxyisoleucine In of fenugreek is an amino acid derivative that assists the pancreas in production of insulin. Studies have shown 4-hydroxyisoleucine reduces fasting blood sugars and improves after-meal glucose tolerance significantly. 4-hydroxyisoleucine works by two separate mechanisms: It has a direct, stimulating effect on insulin production for those who wish to increase their glucose metabolism and helps to reduce glucose resistance and the uptake of glucose, thereby reducing overall blood glucose levels. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing postmeal glucose levels—with little or no increase in blood insulin concentrations— a clear indictor of improved insulin sensitivity
Several studies show that the free amino acid 4-hydroxyisoleucine plays a valuable role in insulin promotion and glucose regulation. 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which blood glucose (the glycemic index) is elevated. Elevated blood glucose after meals leads to increased production of body fat. 4 hydroxyisoleucine promotes insulin secretion and inhibits the rise of blood glucose, thus helping to reduce body fat production. 4 -hydroxyisoleucine exhibits a specific effect on the islets of Langerhans in the pancreas. These cells are directly responsible for insulin production. Most significantly, the effect of 4-hydroxyisoleucine is glucose dependent. The higher the level of blood glucose, the greater the insulin-promoting response elicited by 4 hydroxyisoleucine. Thus 4-hydroxyisoleucine exhibits a significant regulating effect, which corresponds with the insulin needs of the body at any given time. This makes this compound “adaptogenic,” responding to the particular needs of the body at any given time
On top of this testofen In a study with castrated animals this ingredient supported muscle and sexual organ growth just as much as testosterone normally would, essentially showing that it can mimic the effects of testosterone. Other research with male athletes (ages 18-35) showed that 600mg/day of Fenuside extract for 8 weeks dramatically reduced fat tissue while increasing lean muscle.
Of course all of these creats the perfect invirment for Both on cycle use of the product and pct. Both will help to prevent complete shut down or jump start test production (among much more) once again after a cycle.
Now if this is not enough well then how about real human results
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-year-round-695837.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-review-695755.html
http://www.elitefitness.com/forum/anabolic-steroids/hcgenerate-needto-does-again-691319.html
http://www.elitefitness.com/forum/p...rate-if-you-take-nolva-clomid-pct-682879.html
http://www.elitefitness.com/forum/bodybuilding-supplements/my-hcgenerate-experience-687243.html
http://www.elitefitness.com/forum/bodybuilding-supplements/hcgenerate-689005.html
http://www.elitefitness.com/forum/b...ted-hcgenerate-like-i-did-awesome-689589.html
Need To Build Muscle
http://www.steroid ology .com/forum/supplement-forum/156009-hcgenerate-review.html
Those who have used HCGenerate - Need To Build Muscle
HCGenerate Log - Need To Build Muscle
http://forums. steroid .com/showthread.php?p=5018738
NeedToBuildMuscle.Com? - RX Muscle Forums
HCGenerate - RX Muscle Forums
Stuff Romano Likes: HCGenerate for PCT! - RX Muscle Forums
HCGenerate: Super Post Cycle Therapy Supplement from NeedToBuildMuscle.com!
written by jon ramano and dave palobo^^^^^
If all this does not convince you that the product is pretty damn good and can in fact work then I am sorry you got a head like a brick.
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