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Pramiracetam
- Thread starter sirperry1
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Nootropil (Piracetam) is great do 800mg's daily but you will fined that it is a must to use Choline caps 50mg daily with it.
Smart Drugs (Nootropics, Piracetam)
Lets talk a-bit about these wonderful products and how we can use them.
FIRST: Enhance your mental clarity and sensory awareness,
Increase your sex drive,
Enhance school and job performance,
Learn the latest treatments for Alzheimer’s disease,
Increase energy and alertness,
Improve your problem -solving abilities,
Increase your IQ by 10 points or more,
Improve your memory by as much as 40%,
Slow down the aging process,
Smart Drugs (Nootropics, Piracetam)
Lets talk a-bit about these wonderful products and how we can use them.
FIRST: Enhance your mental clarity and sensory awareness,
Increase your sex drive,
Enhance school and job performance,
Learn the latest treatments for Alzheimer’s disease,
Increase energy and alertness,
Improve your problem -solving abilities,
Increase your IQ by 10 points or more,
Improve your memory by as much as 40%,
Slow down the aging process,
Here is some info on Nootropill
Excerpts from Smart Drugs & Nutrients, by Ward Dean, M.D. & John Morgenthaler
Piracetam (nootropyl) is reported to be an intelligence booster and CNS (central nervous system) stimulant with no known toxicity or addictive properties. The subjective effect described by some people is that piracetam, "wakes up your brain." You'll find more personal accounts of the effects of this remarkable drug in the case histories and testimonials appendix. It's effects and safety are so impressive that piracetam prompted the creation of a new pharmaceutical category called nootropics. The term nootropic comes from a Greek word meaning "acting on the mind." Since the invention of piracetam by UCB Laboratories in Belgium, other pharmaceutical companies have been scrambling to develop their own nootropics. Some of them being researched now include; vinpocetine, aniracetam, pramiracetam, and oxiracetam. As yet, there is no nootropic compound that is FDA approved for sale in the US, but there is plenty of motivation on the part of pharmaceutical companies to get that approval. Financial analysts expect that the US market for these cognitive enhancers will soon be in excess of $1-billion per year (Pelton, 1989).
Piracetam is very similar in molecular structure to the amino acid pyroglutamate (see Pyroglutamate). Piracetam and pyroglutamate have the same "base" chemical structure, the 2-oxo-pyrrolidine, but they differ by the side chain. Pyroglutamate is 2-oxo-pyrrolidine carboxylic acid, and piracetam is 2-oxo-pyrrolidine acetamide.
Piracetam enhances cognition under conditions of hypoxia (too little oxygen), and also enhances memory and some kinds of learning in normal humans. Outside of the US, piracetam is used to treat alcoholism, stroke, vertigo, senile dementia, sickle cell anemia, dyslexia, and numerous other health problems (Pelton, 1989).
One of the most intriguing effects of piracetam is that it promotes the flow of information between the right and left hemispheres of the brain (Buresova, 1976). We know that the communication between the two sides of the brain is associated with flashes of creativity. This may also be he basis for piracetam's usefulness in the treatment of dyslexia (Dilanni, 1985).
The effect of piracetam can be increased if taken with DMAE, centrophenoxine, choline, or Hydergine. When choline and piracetam are taken together there is a synergistic effect that causes a greater improvement in memory than the sum of each when taken alone (Bartus, 1981).
We know of one person who claims she feels slightly agitated and depressed if she takes piracetam for more than a week without a choline supplement. This feeling is alleviated for her with a single dose of choline. It may be that the piracetam causes acetylcholine to be used up more quickly and that the choline helps to replace this important neurotransmitter. One fascinating study suggests that piracetam might increase the number of cholinergic receptors in the brain. Older mice were given piracetam for two weeks and then the density of muscarinic cholinergic receptors in their frontal cortexes was measured. The researchers found that these older mice had 30-40% higher density of these receptors than before (Pilch, 1988). Piracetam, unlike many other drugs, appears to have a regenerative effect on the nervous system.
One theory of Alzheimer's disease is that the decline of intellectual functions is partly caused by a decreased activity of the cholinergic system in the brain caused by cell death and cell degeneration. The researchers in the above study speculated that their findings could explain how piracetam works and could also explain the finding of Bartus, et. al. regarding a profound effect of combining choline with piracetam on memory enhancement of old rats.
As mentioned previously the late drug researcher Arthur Cherkin related to us that he believed the combination of Hydergine and piracetam potentiate each other by five times. This highlights the importance of adjusting the dosage when multiple substances are taken because, some of these substances will cause paradoxical effects when excessive amounts are taken.
Although piracetam is a derivative of GABA (gamma amino butyric acid, a neurotransmitter), there is no evidence that piracetam works through the GABAergic system. Some research even suggests GABA may even inhibit memory and learning (Zhang, 1989).
Precautions: Piracetam may increase the effects of certain drugs, such as amphetamines, psychotropics, and Hydergine, as stated. Adverse effects are rare but include insomnia, psychomotor agitation, nausea, gastrointestinal distress, and headaches. Piracetam has virtually no known toxicity or contraindications.
Dosage: Piracetam is supplied in 400 mg or 800 mg capsules or tablets. The usual dose is 2400 to 480
Excerpts from Smart Drugs & Nutrients, by Ward Dean, M.D. & John Morgenthaler
Piracetam (nootropyl) is reported to be an intelligence booster and CNS (central nervous system) stimulant with no known toxicity or addictive properties. The subjective effect described by some people is that piracetam, "wakes up your brain." You'll find more personal accounts of the effects of this remarkable drug in the case histories and testimonials appendix. It's effects and safety are so impressive that piracetam prompted the creation of a new pharmaceutical category called nootropics. The term nootropic comes from a Greek word meaning "acting on the mind." Since the invention of piracetam by UCB Laboratories in Belgium, other pharmaceutical companies have been scrambling to develop their own nootropics. Some of them being researched now include; vinpocetine, aniracetam, pramiracetam, and oxiracetam. As yet, there is no nootropic compound that is FDA approved for sale in the US, but there is plenty of motivation on the part of pharmaceutical companies to get that approval. Financial analysts expect that the US market for these cognitive enhancers will soon be in excess of $1-billion per year (Pelton, 1989).
Piracetam is very similar in molecular structure to the amino acid pyroglutamate (see Pyroglutamate). Piracetam and pyroglutamate have the same "base" chemical structure, the 2-oxo-pyrrolidine, but they differ by the side chain. Pyroglutamate is 2-oxo-pyrrolidine carboxylic acid, and piracetam is 2-oxo-pyrrolidine acetamide.
Piracetam enhances cognition under conditions of hypoxia (too little oxygen), and also enhances memory and some kinds of learning in normal humans. Outside of the US, piracetam is used to treat alcoholism, stroke, vertigo, senile dementia, sickle cell anemia, dyslexia, and numerous other health problems (Pelton, 1989).
One of the most intriguing effects of piracetam is that it promotes the flow of information between the right and left hemispheres of the brain (Buresova, 1976). We know that the communication between the two sides of the brain is associated with flashes of creativity. This may also be he basis for piracetam's usefulness in the treatment of dyslexia (Dilanni, 1985).
The effect of piracetam can be increased if taken with DMAE, centrophenoxine, choline, or Hydergine. When choline and piracetam are taken together there is a synergistic effect that causes a greater improvement in memory than the sum of each when taken alone (Bartus, 1981).
We know of one person who claims she feels slightly agitated and depressed if she takes piracetam for more than a week without a choline supplement. This feeling is alleviated for her with a single dose of choline. It may be that the piracetam causes acetylcholine to be used up more quickly and that the choline helps to replace this important neurotransmitter. One fascinating study suggests that piracetam might increase the number of cholinergic receptors in the brain. Older mice were given piracetam for two weeks and then the density of muscarinic cholinergic receptors in their frontal cortexes was measured. The researchers found that these older mice had 30-40% higher density of these receptors than before (Pilch, 1988). Piracetam, unlike many other drugs, appears to have a regenerative effect on the nervous system.
One theory of Alzheimer's disease is that the decline of intellectual functions is partly caused by a decreased activity of the cholinergic system in the brain caused by cell death and cell degeneration. The researchers in the above study speculated that their findings could explain how piracetam works and could also explain the finding of Bartus, et. al. regarding a profound effect of combining choline with piracetam on memory enhancement of old rats.
As mentioned previously the late drug researcher Arthur Cherkin related to us that he believed the combination of Hydergine and piracetam potentiate each other by five times. This highlights the importance of adjusting the dosage when multiple substances are taken because, some of these substances will cause paradoxical effects when excessive amounts are taken.
Although piracetam is a derivative of GABA (gamma amino butyric acid, a neurotransmitter), there is no evidence that piracetam works through the GABAergic system. Some research even suggests GABA may even inhibit memory and learning (Zhang, 1989).
Precautions: Piracetam may increase the effects of certain drugs, such as amphetamines, psychotropics, and Hydergine, as stated. Adverse effects are rare but include insomnia, psychomotor agitation, nausea, gastrointestinal distress, and headaches. Piracetam has virtually no known toxicity or contraindications.
Dosage: Piracetam is supplied in 400 mg or 800 mg capsules or tablets. The usual dose is 2400 to 480
chillin408
New member
I just started taking piractam and hydergine on monday. I started at 800mg of piractam and 1 tab of hydergine that day but didn't feel much. The next day, tuesday, I took 800mg of piractam twice in the day and felt a noticable difference. I am about to take my second Piractam tonight. It is sorta too earlier to tell if it is making a significant difference. However, my earlier speculations are that it is. I just started school too, so I am hoping it will become more potent. I will make sure to pick up so choline to see if it adds to the potency of P and H.
To futher describe my recent experiences on smart drugs....
--First day: 800mg Piractam 1 tab of hydergine
Didn't feel much.
--Second day 800mg Piractam twice and 1 tab of hydergine. Felt a noticable difference
-- Today took 800mg of piractam this morning and 1 tab of hydergine and about to take another Piractam. I was able to grasp the information presented to me in class pretty well, this morning. I sorta noticle that I am able to think clearer allowing more word choices to flow in my mind as I am talking or writing. Right now, however, I am a little off because I took the piractam 9-10 hours ago, so its probably wared off by now, or very little effect left.
I have heard of the "attack dose", but don't know much about it. I will most likely stick to the dose I am currently adminstering to myself tilll the end of this weekend. After that, I may increase to 2400mg of P and 2 tabs of H...but I really wonder if the H is doing anything. I take the Hydergine at the same time in the morning when I take piractam, but I don't notice much difference from then versus when I take piractam in the evening in isolation. In fact, I felt a stronger effect last night after my piractam dose. It is still too early to make any real judgements on these products effectiveness. So far, I have had no noticable side effects.
To futher describe my recent experiences on smart drugs....
--First day: 800mg Piractam 1 tab of hydergine
Didn't feel much.
--Second day 800mg Piractam twice and 1 tab of hydergine. Felt a noticable difference
-- Today took 800mg of piractam this morning and 1 tab of hydergine and about to take another Piractam. I was able to grasp the information presented to me in class pretty well, this morning. I sorta noticle that I am able to think clearer allowing more word choices to flow in my mind as I am talking or writing. Right now, however, I am a little off because I took the piractam 9-10 hours ago, so its probably wared off by now, or very little effect left.
I have heard of the "attack dose", but don't know much about it. I will most likely stick to the dose I am currently adminstering to myself tilll the end of this weekend. After that, I may increase to 2400mg of P and 2 tabs of H...but I really wonder if the H is doing anything. I take the Hydergine at the same time in the morning when I take piractam, but I don't notice much difference from then versus when I take piractam in the evening in isolation. In fact, I felt a stronger effect last night after my piractam dose. It is still too early to make any real judgements on these products effectiveness. So far, I have had no noticable side effects.
It's interesting that animal stack, pro HGH, creaject and some other seemingly successful supplements contain arginine pyroglutamate. I wonder if the real effects come from it's inclusion... 
Has anyone used pyroglutamate or arginine pyroglutamate specifically? The reason I ask is because I won't order something overseas since I'm not sure about legality issues. Since arginine pyroglutamate is sold in health food stores is makes it interesting and possible for me as well.
Has anyone used pyroglutamate or arginine pyroglutamate specifically? The reason I ask is because I won't order something overseas since I'm not sure about legality issues. Since arginine pyroglutamate is sold in health food stores is makes it interesting and possible for me as well.
pramericetam
Well, I didn't seem to notice much difference between piracetam and pramiracetam. My problem is I have just about every smart drug in the book (I work at a health food store) and need to do more research to find out which ones are providing results. Piracetam and hydergiene have a U-shaped dosage/result plot...meaning studies have shown that more actually negates the effect. I am surprised you are not taking half the hydergiene pill. That and choline, dmae, and piracetam make me nauscious. But also I'm 23, I think older people may respond better. Keep in touch and e-mail me if you want to chat aobut this.
ps- that attack dose really got me fired up, I would recommend it
Well, I didn't seem to notice much difference between piracetam and pramiracetam. My problem is I have just about every smart drug in the book (I work at a health food store) and need to do more research to find out which ones are providing results. Piracetam and hydergiene have a U-shaped dosage/result plot...meaning studies have shown that more actually negates the effect. I am surprised you are not taking half the hydergiene pill. That and choline, dmae, and piracetam make me nauscious. But also I'm 23, I think older people may respond better. Keep in touch and e-mail me if you want to chat aobut this.
ps- that attack dose really got me fired up, I would recommend it
chillin408
New member
I took 800mg of piracetam and 1 tab of hydergine this morning, but I didn't feel anything today. So its still too early......I guess. I think before that it was just a coincidence that I thinking clearer because it happens once in awhile anyway naturally.
What other smart drugs have you guys tried??
I have tried DMAE with vinpocetine and gingko biloba a few weeks ago but I didn't notice anything. Except there is a possibility that it caused me to feel pressure in my head, but that maybe just a coincidence again(or maybe not?). I didn't like the way that combination felt so I quit after a few days. I think I took a low dose of these, I took around 300 mg of DMAE, 5-10 mg of vinpocetine and a very low does of gingko...forgot how much. The dose may have been the reason I wasn't feeling any thearputic benefit, but I have heard people try moderate-high doses of these 3 and didn't feel anything either.
What other smart drugs have you guys tried??
I have tried DMAE with vinpocetine and gingko biloba a few weeks ago but I didn't notice anything. Except there is a possibility that it caused me to feel pressure in my head, but that maybe just a coincidence again(or maybe not?). I didn't like the way that combination felt so I quit after a few days. I think I took a low dose of these, I took around 300 mg of DMAE, 5-10 mg of vinpocetine and a very low does of gingko...forgot how much. The dose may have been the reason I wasn't feeling any thearputic benefit, but I have heard people try moderate-high doses of these 3 and didn't feel anything either.
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