I think running smaller doses over a longer period of time has its merits.
I consider 200mg/day a small dose. At this level, I rarely get into issues with getting really hot. I can feel an increased warmth so I dress cooler. Use small fan in my office sometimes and try not to get into heated discussion. When this happens my adrenanline gets going and I start getting hot.
At this dose, lethargy is minor. Workouts are almost 100%. It is also easier to stay hydrated and it is more likely that the anti-oxidants won't be overwhelmed.
I will bump to 400mg/day for a day or two on the weekend. But I will also skip days if I am going out or something.
When I did my first cycle, I ran at 400mg/day and 600mg/day. At these doses, your body cannot fuel itself fast enough from fat stores alone, so it goes after glycogen stores. When this happens you feel flat, tired and weak.
At the lower dosages, your glycogen stores are not effected as much. Of course the fat loss is not as fast, but with low dose you run it longer.
For me, this seems to work out best. I don't think that I will use DNP over 400mg/day again. More comfortable to run the lower doses longer.
P.S. I run 12.5mg T3 2x per day