Without making this a huge post. The summary answer is yes, PH, DS, and AAS (including injectables) all put a strain on the liver. Orals are so harsh because their first pass is through the liver and then into the bloodstream. Injectables, are much more mild because they don't do their first pass through the liver, but the liver being a filter organ, they will eventually hit the liver so they do have an effect, but not nearly to the degree of orals.