Letrozole good for Tren Prolactin?

[jacshelb]

bigrand,

I think the problem Macro is reffering to is that nolva makes the nips sensitive to tren/deca gyno. So, it can be a bad idea for those that are prone. Something like letro in reasonable doses might help on its own, though.


Jacob

 

[bigrand]

Since AIs downreg PGr and nolva is a ER antagonist, and MIGHT have some effect on lowering prolactin....all areas should be covered!

 

[macrophage69alpha]

Since AIs downreg PGr and nolva is a ER antagonist, and MIGHT have some effect on lowering prolactin....all areas should be covered!

the downregulation of PgR is likely abrogated by nolva, since its direct binding is the most likely cause of upregulation.

AI's downregulate through the reduction in estrogen. Nolva's action in this case is estrogenic.

 

[Harleymarleybone]

this is fallacy. though have seen it posted a # of times.

Can you provide any studies that show it is a fallacy? Here is a study that says otherwise:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=139428

Mammary gland development is defined by the formation of ductal epithelial cells, which requires estrogen and EGF, and of lobular alveolar epithelium, which proliferates in response to prolactin and progesterone [23,24]. STAT5A, which can be activated by EGF and prolactin, is required for mammopoiesis and lactogenesis, as determined by knockout experiments [17,25].

 

[Harleymarleybone]

post menopausal women actually have a relatively similar hormonal milieu to men. its the estrogenic action of tamoxifen that upregulates PgR expression which is why its not seen with aromatase inhibitors. once again noting that trenbolone and nandrolone are PgR binders.

I can just as easily argue that post-natal women have a hormonal millieu more similar to male tren gyno sufferers (which is what we are talking about, after all) than menopausal women. The both have high levels of prolactin and are on the verge of lactating. Not so with menopausal women.

 

[Harleymarleybone]

no, but with your logic skills its not surprising that you might infer that.

Hey, you are the one who said "male progesterone." Maybe it would have been better top say "progesterone in males." Merely a sematic point.

 

[Harleymarleybone]

what you have failed to realize during this exchange is that nolva is not reccomended because it CAN, not necessarily will, Exacerbate progestenic and prolactin issues (secondarily via upregulation of the PgR).

Yes I realize that is your claim, though you have not provided any studies that provide a basis to conclude it exacerbates gyno (only anecdotal evidence, which is the worst form of support.) But let's assume, it can. Since you don't provide any odds, the possibility could be very low; in which case the likely benefits could outweigh the likely risks, just like any other side-effect.


if progestins are used its better to use an aromatase inhibitor (though with tren alone this has its caveats), then if needed add a prolactin suppresor.

Nolva is also not reccomended because of its half life.

If nolva can reduce prolactin as one of my studies shows, and if estrogen is a necessary component of gyno as one of my other studies shows, then Nolva would seem to help. If it does cause problems (and what are the odds?), one can add the necessary AI's or dopamine agonists.

 

[dospuntos96]

this is possibly the best thread ever. but after reading he said/he said, i'm still needing sorted out on my third cycle, which is tren/eq. what's best for no boobs? i got aifm,nolva and clomid from previous pcts! or, i just might run 2week tren only cycles like before, while taking 300mg b6/day. any studies on the efficacy of b6?

 

[macrophage69alpha]

I can just as easily argue that post-natal women have a hormonal millieu more similar to male tren gyno sufferers (which is what we are talking about, after all) than menopausal women. The both have high levels of prolactin and are on the verge of lactating. Not so with menopausal women.

one again trenbolone is not progesterone and trenbolone does not necessarily elevate prolactin levels. IT CAN.

 

[macrophage69alpha]

Can you provide any studies that show it is a fallacy? Here is a study that says otherwise:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=139428

Mammary gland development is defined by the formation of ductal epithelial cells, which requires estrogen and EGF, and of lobular alveolar epithelium, which proliferates in response to prolactin and progesterone [23,24]. STAT5A, which can be activated by EGF and prolactin, is required for mammopoiesis and lactogenesis, as determined by knockout experiments [17,25].

actually your cite indicates it.

why dont you re-read it.

keeping in mind of course that at some point, like say during life and particularly during puberty males are exposed to estrogen, often high levels of it..