Letrozole good for Tren Prolactin?

[macrophage69alpha]

If nolva can reduce prolactin as one of my studies shows, and if estrogen is a necessary component of gyno as one of my other studies shows, then Nolva would seem to help. If it does cause problems (and what are the odds?), one can add the necessary AI's or dopamine agonists.

where high E is the cause, yes it can, but aromatase inhibitors produce the same effect without upregulating the PgR. And yes nolva can have effects, but it can also worsen the issue.

ITS A POOR CHOICE, in a field of many better choices.

 

[bigrand]

Well, the combo works good for me....ill run it a few more weeks, drop the nolva and letro, and run aromasin for 100 days.

 

[Harleymarleybone]

actually your cite indicates it.

why dont you re-read it.

keeping in mind of course that at some point, like say during life and particularly during puberty males are exposed to estrogen, often high levels of it..

I think you are more interested in obfuscating and "winning" an argument than the truth. Let me recap the dialectic so others, at least can see what is happening here:

You said the following is a fallacy:

"estrogen is the critical component in breast tissue development and progesterone is additive, but without the estro agonism, you wont see much..."

My study confirms this. It says: "Mammary gland development is defined by the formation of ductal epithelial cells, which requires estrogen and EGF, and of lobular alveolar epithelium, which proliferates in response to prolactin and progesterone [23,24]. STAT5A, which can be activated by EGF and prolactin, is required for mammopoiesis and lactogenesis, as determined by knockout experiments [17,25].

So according to this study, the bright, and not just argumentative gentleman, who said estrogen is critical to gyno and progesterone/prolactin an additive, is correct, and your thinking it a fallacy is incorrect. Of course we know that even though you have supplied no scientific credentials, we are supposed to take your mere word, and deny objective, peer-reviewed research on the matter

Now let's think for a moment, with respect to the efficacy of Nolva on gyno, given the fact that estrogen is indeed a necessary component of true gyno. Though Tren/Deca etc. are not themselves estrogenic, males still have endogenous naturally occuring estrogen in their systems, as you yourself recognize above,- not male estrogen running around in khakis - just estrogen ;-). Whatever the source of the estrogen is, an anti - estrogen like Nolva is going to generally help, since it will help knock out a necessary component of any actual gyno. The dopamine antagonists will help knock out the other components. That it *can* exacerbate it is not an argument that it should not be used. Anti-depression drugs can also exacerbate depression, but they help many people, too, and this is not a reason not to take them. So the exacerbation argument is not real convincing.

Capice?

 

[macrophage69alpha]

estrogen is systemically present throughout the life cycle. According to the study that you tout, estrogen is merely necessary for formation---- which takes place, to one extent or another, well before anyone here uses steroids, now estrogen will also cause futher formation however existing structures will be agonized by progestins, EGF and prolactin. so try to wrap your head around that before making any further statements.

you have continuously cited research that you lack the ability to understand. You have demanded studies on compounds that does not exist and wont. You have been given studies from which you should be able to extrapolate the necessary understanding of the potential issues that nolva presents.

the problem here is you think this is an argument to be won. Its not. This is about what are the best reccomendations for members of this forum.

nolva upregulates the PgR, aromatase inhibitors downregulate the PgR. Why exactly do you persist in reccomending nolva with progestins? even if the chance is small that nolva increases gyno risk over AI's, which it is not (if you spent more time actually dealing with people that have gyno issues you would realize this) why take such a risk?


NOTE- if nolva had a 1-2 day half life, trying it would not be an issue especially since if the issue is not significantly due to PgR activity or seconday effects of PgR binding it can be effective (though again in numerous clinicals AI's have been shown to be significantly more effective in gynecomastia). but since it has a 10 day half life, 14 days or more with use after several weeks if it does cause or exacerbate issues, you are stuck with it. Keeping in mind 3 half lives to elimination, 5 half lives to extinction.