Letrozole good for Tren Prolactin?

[medrep]

No biggie...just enjoying this thread.

heavyweight bout yes, but still tied

 

[Harleymarleybone]

All I know is that I got my worst gyno (only gyno really) when I was using tren and nolva together for the first time. I've done the same cycle since a few times, sans nolva and not had any gyno symptoms.


Jacob

So you did a cycle of just Nolva and Tren, and then just Tren? Very unique

 

[bigrand]

I'm curious, reduced TEMPORARILY or reduced PERMANENTYL? I'm about to start my first tren run and have a little chest fat thinking of letro

Well, i can tell you it is very noticable. I did gain a good amount back, but i was running NPP (i think that shit makes me fat easy) and drol with no AI....i got a little lax, but about 5 weeks into this.....dramatic results from those drugs. I need to run aromasin about 100 days when im done with letro (about 50 days post cycle) and stay on top of things a little better this time and i should be good.
GIve it a go, youll like the results.

 

[macrophage69alpha]

So you did a cycle of just Nolva and Tren, and then just Tren? Very unique

not really. a lot of homebrewers just run trenbolone (not reccomended). Since it can be easily and legally (relatively) acquired.

 

[Harleymarleybone]

since when did progestins become progesterone? remember last week in class when mrs. hinkledumper explained that humans are mammals but not all mammals are humans. progesterone is a progestin, but not all progestins are progesterone.

progestins are compounds that bind to the PgR, they can have vastly different activity. Trenbolone has both agonist and antagonistic activity. Progesterone on the other hand is a pure agonist.

even other agonist compounds can have VASTLY different transcriptive effects.

you might also want to consider carefully before relating post natal hormonal fluctuations in women to men.

Obviously, the point was that increased PgR expression does not necessarily cause increased prolactin expression, (or gyno through other mechanisms.) Progesterone is an example, where, indeed, there is an antagonistic affect with respect to prolactin.

So you have still not provided evidence of what I originally asked for - that Nolva can increase prolactin or gyno (not just PgR expression).

 

[Harleymarleybone]

Oh, I also find it a little odd to stress this when nearly all of the drugs we are discussing and taking were made for women and their hormonal fluctuations problems.

Plus, like you said before, there is very little direct research on the type of use we are making for these drugs, so the best we can do is extrapolate from cases like this to our purposes.

 

[macrophage69alpha]

Oh, I also find it a little odd to stress this when nearly all of the drugs we are discussing and taking were made for women and their hormonal fluctuations problems.

its not odd at all, you are comparing two very different hormonal systems, pregnancy and its hormonal milieu being nearly the height of that differential.

Aromatase inhibitors were designed to explore the impact of the aromatase system and of estrogen in both males and females. They may have been pharmaceutically developed to treat breast cancer, because aromatase is a key factor in it, however that is a considerably different situation. and there is considerable research on aromatase inhibitors in men.

you cited a particularly irrellevant study, which even were it relevant to male progesterone does not in any way address the differential impact of progestins, which are not progesterone.

 

[jacshelb]

So you did a cycle of just Nolva and Tren, and then just Tren? Very unique

No. No, I didn't. I did a cycle of T-3, Tren, Prop, with nolva as the anti-e. To be honest, I'm hesitant to touch t-3 again because I suspect it may have also played a role in my gyno. But, after I stopped the T-3 I still took Nolva for a long while thinking I was helping myself. Things just kept getting worse and worse. After stopping the nolva and using some letro and dostinex, then keeping off everything for several months, I was fine. Not much of a trace of gyno at this point.

I've done two mentionable cycles of Prop and tren since then and used tiny amounts of letro throughout- then tapering off of everything slowly (what can I say- I just believe in tapering and it works for me). I haven't had so much as a BIT of nipple soreness. No joke.

Now, was it the t-3 or the nolva that helped me get gyno? I don't know. But, I'm doing well without either. The t-3 flattened me out anyhow.

On the other side of things, I have a friend who is on some psychological drugs that increase estrogen and I gave him my leftover nolva. He loves it. I can see that his chest fat has dramatically decreased. He ISN'T on tren or deca, however. I'm saying that Nolva isn't bad stuff. But, if you are prone to progesterone gyno, you might want to stay away from it. But, if you don't believe me, give it a try. Just remember how long it stays in your system before you take the risk.

Look, you can believe whatever you want. In fact, most of the time, just about any stance can be backed up with research of some type. I know what I've been through, and I'd rather not risk using Nolva again- especially when there are so many other much more effective anti-e's out there. That's just my opinion.


Jacob

 

[jacshelb]

not really. a lot of homebrewers just run trenbolone (not reccomended). Since it can be easily and legally (relatively) acquired.

True. I've got a friend who once did a 17+ week cycle of Tren only. Ugh. He loved it, though. He said he was horny as hell and hungry all the time. And, man, did it work for him while he was on it. He looked amazing. After he came off, he was shut down so hard (I'm assuming) that he lost everything he'd gained. He still looked good, just 20 lbs. lighter and not as hard! lol. Oh well, to each his own. I like my little short tren and prop combos. The test seems to keep my mood in check.


Jacob

 

[macrophage69alpha]

the primary issue with nolva is that if it does start to cause problems, because of its rediculous half life (14 days after only several weeks of use) you cant just stop it.

and just to be CLEAR...no one has said that nolva will always cause gyno or exacerbate gyno with progestins, but it CAN or that progestins or progestins + nolva will always raise prolactin but they can. Better to choose an option that WONT, an aromatase inhibitor or a dopaminergic (or both- depending on what one is taking).

half life is also why dont reccomend nandrolone decanoate, only NPP. for that that have problems its much easier to get off.