Letrozole good for Tren Prolactin?

[jacshelb]

the primary issue with nolva is that if it does start to cause problems, because of its rediculous half life (14 days after only several weeks of use) you cant just stop it.

and just to be CLEAR...no one has said that nolva will always cause gyno or exacerbate gyno with progestins, but it CAN or that progestins or progestins + nolva will always raise prolactin but they can. Better to choose an option that WONT, an aromatase inhibitor or a dopaminergic (or both- depending on what one is taking).

half life is also why dont reccomend nandrolone decanoate, only NPP. for that that have problems its much easier to get off.

I want to be clear in case there has been any misunderstanding. Macro, I am totally in agreement with you on this. Everything you just said is gospel to my ears. In fact, it was your help that saved my sorry aching tits the first time around and I want to thank you for that. This ain't ass kissing. This is gratitude.


Jacob

 

[Harleymarleybone]

its not odd at all, you are comparing two very different hormonal systems, pregnancy and its hormonal milieu being nearly the height of that differential.

Aromatase inhibitors were designed to explore the impact of the aromatase system and of estrogen in both males and females. They may have been pharmaceutically developed to treat breast cancer, because aromatase is a key factor in it, however that is a considerably different situation. and there is considerable research on aromatase inhibitors in men.

you cited a particularly irrellevant study, which even were it relevant to male progesterone does not in any way address the differential impact of progestins, which are not progesterone.

So now you are saying there are male and female progesterone? Do the little female progesterones wear skirts, and the males kakhis?

If my study is irrelevant, then your study is irrelevant too, since its subjects were composed of post-menopausal breast cancer patients. To use your lingo you are comparing two very different hormonal systems, female post-menopausal cancer patients and its hormonal milieu being very different."


My study is obviously relevant and suggestive, since it refutes your study in the following way: Your study says that Tamoxifen increases PGR expression, and then you infer from that that it increases prolactin or gyno. But oops, that is a mistake, since my study shows progesterone which also increases PGR expression, decreases prolactin. So obviously mere increase in PGR expression does not logically entail increase in prolactin, the primary culprit of tren gyno.

A little learning is a dangerous thing.

 

[bigrand]

Nolva being a SERM is an antagonist in breast tissue, how will you GET gyno from tamox? I know there are other hormones that play a role, but if i remember correctly, estrogen is the critical component in breast tissue development and progesterone is additive, but without the estro agonism, you wont see much....ill try to find where i read that.
Nolva and tren and letro lean me out with not a trace of gyno. And i ALWAYS have fluid discharge from the side of my nipple, so i think i have some prolactin problems, but tren and nolva seem to be great.

 

[macrophage69alpha]

but without the estro agonism, you wont see much....ill try to find where i read that.

this is fallacy. though have seen it posted a # of times.

 

[macrophage69alpha]

If my study is irrelevant, then your study is irrelevant too, since its subjects were composed of post-menopausal breast cancer patients. To use your lingo you are comparing two very different hormonal systems, female post-menopausal cancer patients and its hormonal milieu being very different."
.

post menopausal women actually have a relatively similar hormonal milieu to men. its the estrogenic action of tamoxifen that upregulates PgR expression which is why its not seen with aromatase inhibitors. once again noting that trenbolone and nandrolone are PgR binders.

 

[Harleymarleybone]

the primary issue with nolva is that if it does start to cause problems, because of its rediculous half life (14 days after only several weeks of use) you cant just stop it.

and just to be CLEAR...no one has said that nolva will always cause gyno or exacerbate gyno with progestins, but it CAN or that progestins or progestins + nolva will always raise prolactin but they can. Better to choose an option that WONT, an aromatase inhibitor or a dopaminergic (or both- depending on what one is taking).
.

Assuming it is possible, one also has to consider the probabilities, since low probability could factor into taking Nolva since some of these options, the latter, especially, can have very undesirable sides, too. If everything else were equal including equal access to all the options, I would not necessarily choose Nolva. But that are are cases when it is reasonabe to use Nolva, for example coincidentally enough, I have a friend who is getting Tren gyno, and has no other options than Nolva on hand. I told him to start taking it. Meanwhile we are ordering some dostinex to be safe. More anecdotal evidence for my side:



800mg test prop
600mg primo
75mg tren eod
50mg proviorn ed


i have took nolva and the itchy nipples have stopped but i will continut to take 20mg ed just to be safe .

squig

http://www.muscletalk.co.uk/urgent_advice_rquired_Tren_Gyno_(maybe)/m_585571/tm.htm

Granted he is taking test, etc., also but most reasonable people run test with tren, so Nolva is =called for anyway. Still, I bet tren and prolactin is the cultprit.



_____________________________

4 month cycle

500mg sus each week
50mg winny tabs for six weeks then changing to anavar

 

[macrophage69alpha]

So now you are saying there are male and female progesterone? Do the little female progesterones wear skirts, and the males kakhis?

no, but with your logic skills its not surprising that you might infer that.

 

[macrophage69alpha]

800mg test prop
600mg primo
75mg tren eod
50mg proviorn ed


i have took nolva and the itchy nipples have stopped but i will continut to take 20mg ed just to be safe .

squig

http://www.muscletalk.co.uk/urgent_advice_rquired_Tren_Gyno_(maybe)/m_585571/tm.htm

Granted he is taking test, etc., also but most reasonable people run test with tren, so Nolva is =called for anyway. Still, I bet tren and prolactin is the cultprit.

there is no basis for inferring that prolactin IS the issue here. Though it might be PART of the problem. Estrogen is likely the primary driver, through the progestenic binding of Tren as well as its upregulation of IGF-1 (which nolva will reduce) are also other possible factors.

what you have failed to realize during this exchange is that nolva is not reccomended because it CAN, not necessarily will, Exacerbate progestenic and prolactin issues (secondarily via upregulation of the PgR).

if progestins are used its better to use an aromatase inhibitor (though with tren alone this has its caveats), then if needed add a prolactin suppresor.

Nolva is also not reccomended because of its half life.

 

[jerichohill]

Lets hear some more. This is good dialogue.

 

[bigrand]

What about using tren nolva AND an AI? As ive stated, ive had good results.
Still have nipple discharge....through it was breast cancer after my prolactin levels showed to be normal, but ive had the problem for like 4 or more years and no signs of a growth after that long...i think im safe, no Kleinfelter syndrome here either.