Letrozole good for Tren Prolactin?

[Harleymarleybone]

not really. if you search the forums you will find the opposite, anecdotal evidence indicates that it worsens it or even causes it in PCT. use of nolva for PCT after tren or nandrolone is one of the most common factors in post cycle gyno.

though that being said, nolva will work for some- usually because its IGF-1 or estrogenic factors that are at work.

Volker W, Gehring WG, von zur Muhlen A, Schneider J.
In the present study the combination of tamoxifen and bromocriptine was tried for the suppression of prolactin in prolactin secreting adenomas which were resistant to suppression with bromoergocriptine alone. 10 women under treatment with 2.5-10 mg of parlodel (bromocriptine) for pituitary tumours of various sizes were additionally treated with tamoxifen 10-20 mg. (nolvadex) daily. Two patients had a previous incomplete resection for chromophobe adenomas. The other patients refused operation. Two women were also studied who did not tolerate a bromoergocriptine therapy because of side effects. In 6 of the 10 women with combination treatment a satisfactory suppression of the prolactin was observed. Four women were cleared of their amenorrhoea and galactorrhoea. One woman conceived. One woman lost her frigidity. Three women, among those the two with severe side effects from bromoergocriptine, tolerated the combined treatment well. Four women showed no success with the combined treatment. The effectiveness of the combined treatment was not correlated with the size of the tumour nor the clinical or biochemical baseline. *The results lead to the conclusion that tamoxifen is capable of improving the suppression of prolactin or render the adenomas suppressible in a large number of cases.*

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6924910&dopt=Abstract


There are other studies that show Nolvadex suppresses prolactin, too. If you have it on hand give it a try.

 

[NickyE3]

lot of confusion with nandrolones and gyno is the reason I plan to never touch the stuff

 

[Harleymarleybone]

not really. if you search the forums you will find the opposite, anecdotal evidence indicates that it worsens it or even causes it in PCT. use of nolva for PCT after tren or nandrolone is one of the most common factors in post cycle gyno.

though that being said, nolva will work for some- usually because its IGF-1 or estrogenic factors that are at work.

Another study:

Lamberts SW, Verleun T, Oosterom R.
Bromocriptine treatment of patients with invasive prolactin (PRL)-secreting pituitary adenomas does not invariably result in normalization of the plasma PRL levels. We previously showed that the antiestrogenic drug tamoxifen inhibited hormone release from transplantable PRL-secreting pituitary tumors in rats. In 8 patients with invasive PRL-secreting pituitary adenomas with extrasellar extension, the effect of the administration of tamoxifen was investigated on the plasma PRL concentration and on the bromocriptine-mediated inhibition of PRL release. Treatment for 5 days with tamoxifen (20 mg/day) suppressed plasma PRL levels as measured in 5 samples over the day significantly by 20 +/- 3% (means +/- SEM; p less than 0.01). During tamoxifen administration the inhibition of PRL secretion by 2.5 mg bromocriptine was further suppressed by 36 +/- 7%, in comparison with the plasma PRL levels after bromocriptine alone (p less than 0.01). Tamoxifen administration suppressed PRL release in patients with giant invasive PRL-secreting pituitary adenomas, and it had a slight but significant additive or potentiating effect on the bromocriptine-mediated inhibition of PRL secretion. However, despite the simultaneous administration of bromocriptine and tamoxifen, normalization of the circulating PRL levels was not reached in this type of patient.

http://www.ncbi.nlm.nih.gov/entrez/...=Retrieve&dopt=abstractplus&list_uids=7078703

 

[macrophage69alpha]

these studies are not particularly relevant, though your searching is commendable. Since the issue here is not prolactin secreting adenomas but progestenic impact on prolactin. None of these people were taking 19-nor steroids. And nolva has been shown to upregulate the progesterone receptor. Whereas AI's have been shown to down regulate it.

nolva is somewhat effective when estrogen is the inducer of prolactin (though not as effective as AI's). When you throw a progestin in the mix, the entire equation changes.

 

[Harleymarleybone]

these studies are not particularly relevant, though your searching is commendable. Since the issue here is not prolactin secreting adenomas but progestenic impact on prolactin. None of these people were taking 19-nor steroids. And nolva has been shown to upregulate the progesterone receptor. Whereas AI's have been shown to down regulate it.

nolva is somewhat effective when estrogen is the inducer of prolactin (though not as effective as AI's). When you throw a progestin in the mix, the entire equation changes.

Sorry but your post does not really make sense, - the stuff about progesteronic impact on prolactin, etc. The main issue with Tren Gyno is Prolactin build up, not progesterone itself. These studies show that Nolva suppresses prolactin. The cause of the prolactin build up is not important (adenomas, exogenous drugs, etc.) Prolactin is prolactin. Also, even if Nolva did make progesterone receptors more sensitive (and this is not conclusive), that really means nothing unless you can show it is so significant that it offsets the benefits of the prolactin suppression of Nolva.

This research would explain why Nolvadex has helped many people in suppressing Tren gyno.

Also, I would be curious to know what your medical or research credentials are. Do you have advanced degrees in any areas related to these matters?

 

[macrophage69alpha]

In red
just because you dont understand it, does not mean it does not make sense or is innaccurate

Sorry but your post does not really make sense, - the stuff about progesteronic impact on prolactin, etc. just because you dont understand it, does not mean it does not make sense or is innaccurate
The main issue with Tren Gyno is Prolactin build up, not progesterone itself. not really, prolactin is just a factor, hence why prolactin suppression is not always effective. the issue caused by tren derive from its binding to the PgR, one impact of which is (though this varies) increasing prolactin
These studies show that Nolva suppresses prolactin. when ESTROGEN is the primary factor, and while it does this AI's are MORE effective
The cause of the prolactin build up is not important (adenomas, exogenous drugs, etc.)really, because its very important. since usually those things have other impacts, not just increasing prolactin
Prolactin is prolactin. Also, even if Nolva did make progesterone receptors more sensitive (and this is not conclusive)its conclusive, and it upregulates their expression though it may also modulate their activity
, that really means nothing unless you can show it is so significant that it offsets the benefits of the prolactin suppression of Nolva.

This research would explain why Nolvadex has helped many people in suppressing Tren gyno.your basing your premise on false assumptions, nolva generally does not help and often makes the situation worse.

 

[caliboy]

All I can tell you is dostinex worked great when i was using tren. if it works thats what counts to me.

 

[brino]

totally with macro cause ive had that kind of gyno from superdrol, but one thing i found and a few others on here have also tried is chasteberry it seems to dry up the prolactin and its cheap. Use that with letro and if it dosnt work get the other stuff.

 

[52_21_30]

All I can tell you is dostinex worked great when i was using tren. if it works thats what counts to me.

Ditto. If I lived my life according to the conclusions of medical literature articles funded by third parties with vested interest in the results I'd probably just off myself to save the trouble.

 

[Harleymarleybone]

Ditto. If I lived my life according to the conclusions of medical literature articles funded by third parties with vested interest in the results I'd probably just off myself to save the trouble.

That makes a lot of sense. Ignoring peer-reviewed research by reputable qualified authorities at reputable institutions, and making important decisions about health based on of self- and often mis-educated meatheads and so-called gurus (often with vested interests.)