Letrozole good for Tren Prolactin?

[bigrand]

Tren+letro+nolva much gyno/titfat reduction....with VERY little added cardio. The leanest ive ever been was after running tren/drol/letro/nolva for 2 months. Rebounded after i used NPP twice however......that stuff makes me fat.

 

[caliboy]

That makes a lot of sense. Ignoring peer-reviewed research by reputable qualified authorities at reputable institutions, and making important decisions about health based on of self- and often mis-educated meatheads and so-called gurus (often with vested interests.)

lol..I knew that was coming. i like reading all the info i can..i was just telling my exp with the dostinex. I never have claimed to be a meathead, guru, or anything but a average user. Most of what we go by is from our peers in bb community. it wasnt to long ago that "experts" were telling athletes that aas did not promote muscle mass. All my post said was this is what i used and found..it didnt say go do it or go buy the stuff..just my exp.

 

[Harleymarleybone]

In red
just because you dont understand it, does not mean it does not make sense or is innaccurate

I did not say I did not understand it. I said it does not make sense. Prolactin is the issue with Tren gyno. I have provided two studies from peer-reviewed journals (Neuroendocrinology) which show that Nolva suppresses prolactin. (Prolactin is prolactin. There is no progesterone -prolactin, and estrogen -prolactin) So, far you have provided no scientific evidence that Nolva increases prolactin and "makes the situation worse."

And can I assume that since you did not answer my question about your formal scientific credentials, you don't have any? If so, it looks like I have provided some very reputable authorities and suggestive studies to support my claim, while you have provided no evidence to support yours (other than anecdotal, which I also have).

But by all means feel free to supply the actual science at your leisure.

 

[Harleymarleybone]

lol..I knew that was coming. i like reading all the info i can..i was just telling my exp with the dostinex. I never have claimed to be a meathead, guru, or anything but a average user. Most of what we go by is from our peers in bb community. it wasnt to long ago that "experts" were telling athletes that aas did not promote muscle mass. All my post said was this is what i used and found..it didnt say go do it or go buy the stuff..just my exp.

I wasn't referring to you or anybody in particular, big caliboy. Dostinex works fine, for many people. Nolva works for some people. It suppresses prolactin in the same way. Yes, the scientific experts can and do get it wrong, sometimes, but they are still the best source of knowledge we have about these issues. And non-experts get it wrong even more. So, I'll go with the scientists when it comes to my health. I just find it odd and a little reckless when people so non-chalantly reject the actual science and go with the hearsay, which is often myth.

 

[macrophage69alpha]

I wasn't referring to you or anybody in particular, big caliboy. Dostinex works fine, for many people. Nolva works for some people. It suppresses prolactin in the same way. Yes, the scientific experts can and do get it wrong, sometimes, but they are still the best source of knowledge we have about these issues. And non-experts get it wrong even more. So, I'll go with the scientists when it comes to my health. I just find it odd and a little reckless when people so non-chalantly reject the actual science and go with the hearsay, which is often myth.

this is just not correct. Nolva reduces prolactin when estrogen agonism is the cause. Dostinex reduces prolactin via the dopaminergic system. Someone can have low estrogen levels and still have high prolactin levels.

this is not a one mechanism system... You cant pull a couple studies off medline (which you misinterpreted) and then make claims. thats the kind of action that leads to the myths you claim to abhor.

 

[macrophage69alpha]

I did not say I did not understand it. I said it does not make sense. Prolactin is the issue with Tren gyno. I have provided two studies from peer-reviewed journals (Neuroendocrinology) which show that Nolva suppresses prolactin. (Prolactin is prolactin. There is no progesterone -prolactin, and estrogen -prolactin) .

You are right. YOU did not say it.

you did provide 2 studies, if you had understood those studies you would realize that ER antagonism resulted in lowered prolactin in pituitary adenomas (TUMORS) because ER agonism was elevating it. So in ER positive pituitary adenomas (which if you had research are frequently ER positive), Nolva can have a significant effect. You will note the success rate was less than 50% (actually under the occurance of ER positive adenomas- though it was a small study group). You will also note in the study you provided where bromocriptine was used it provided significantly greater suppression of prolactin release. (though also even combination treatment was inneffective in that study)

prolactin is prolactin, but what causes the secretion and thus what inhibits that secretion can be very different. the Dopaminergic system DIRECTLY opposes prolactin release, hence it is the best first line treatment for prolactin issues.

will not repeat the arguments from your other thread (insert here and read again)

 

[medrep]

which gyno is enlarged ariola and slightly pointy nips, but no lump or lactation?? Is letro for this too?>?

 

[Harleymarleybone]

this is just not correct. Nolva reduces prolactin when estrogen agonism is the cause.


Please provide any study that shows that Nolva suppresses prolactin only when estrogen is the cause.

 

[macrophage69alpha]

this is just not correct. Nolva reduces prolactin when estrogen agonism is the cause.[/qoute]


Please provide any study that shows that Nolva suppresses prolactin only when estrogen is the cause.

you can look through the studies your self, You will find that in cases other than treatment for pituitary adenomas (ER positive only), tamoxifen either has no impact, minimal impact or raises prolactin.

 

[Harleymarleybone]

So in ER positive pituitary adenomas (which if you had research are frequently ER positive), Nolva can have a significant effect. )

Actually, it also has an effect on ER negative cells:

http://www.nature.com/onc/journal/v18/n29/abs/1202755a.html

(among many others)

That would also explain why Nolva works for many people with tren gyno. Not saying and never did say it was the best. Since you have not provided any studies to show it there is a particular danger in increasing prolactin, there is no good reason not to use it.