Ok well i am planning on a big blast before I cruz this winter with EQ, Prop/susp, Mast, Premo, Tren, and Dbol, so I think this is my insurance against some negative sides.
Obviously, you can't expect to do massive amounts of harsh gear and think it'll be free of any sides as long as you just take N2GUARD. But it will definitely cut down on them and reduce the damage. For modest cycles you'll be able to avoid most sides completely.