Is there a high yield, for sure method to seperate the estradiol from synovex.

[Nucman]

I've seen a post where you do a recrystalization, and another site has a mystery "soluabilizer" solution. I think the estradiol has a phenol attached? How would someone get rid of the estradiol? Hypothetically speaking, a person wouldn't want to use some unknown chem.

 

[Barak]

There is a Kit on the market that is reliable, however all methods I have seen used still left about1-1 1/2 percent of the estradiol, I have used the kit and it yields a pretty good product(powder) to mix up

 

[Nucman]

Someone must know how to make the estradiol benzoate water soluble, or another solvent that one is soluble in and the other is not. Seems like that's the trick to this thing.

 

[JuicePimp]

From what I hear, the recrystalization method if done right, test the melting point, etc. can pretty much elimiate the estradiol.

 

[Nucman]

The info I have says the melting point of EB is190*C, and TP 118*C. So how would you ever tell if there were EB in there by testing the MP?

 

[balls]

Becasue your melting point will be below 118 if contaminated with eb

 

[Nucman]

Why would it be lower if the MP of EB is higher? No matter what, the EB wont melt until 190*, and the TP wont melt below 118*. I would think some other contamanent is in there if something melts in your sample below 118*. . . . Not for sure, but it makes sence to me.

 

[balls]

Check a basic organic chemistry textbook if you don't believe me. Even if the contaminant has a higher melting point, the mixture will always display a melting point BELOW the melting point of the major constituent. It will melt below 118 if contaminated.
A sharp melting point at 118 will indicate high purity. A broad melting point starting below 118, and going over several degrees, indicates its impure.
Hope that helps

 

[Nucman]

How bout Na or K tertiary butoxide? It ought to strip the EB to a salt which can be washed away.

 

[balls]

Let me know exactly what you are separating, the solvent or matrix that it is in, and I'll give you my opinion.