Interesting Info On Dostinex

[gjohnson5]

I for one took generic cabaser @ 2mg / day and also saw no libido increase. Infact it seemed to decrease

I just got back from my doc to get my blood levels checked. I've been off for about 6 months, but I'll be starting again soon. Keep in mind that this guy sits on the IOC board for drug testing and he works with athletes and BB's monitoring their blood test regularly. In other words he knows his shit. I asked him about taking dostinex since I'll be using tren again. He asked why I wanted to use it. I said for prolactin levels, since that seems to fuck up your sex drive. He said that Dostinex will decrease prolactin levels by supressing the release of it. However that won't increase sex drive directly. What it will do is this: When a male has an orgasm a large amount of prolactin is released. That's why it takes men awhile before they can get aroused again and have sex. If you prevent that release by taking dostinex, you will be able to have mutiple orgasms! . He said if you want to use it for better sex it works great. I said hell yeah dawg! It doesn't do anything for progesterone and it doesn't do anything for sex drive. Thought you guys would appreciate this info. You can thank me later Satch...

 

[gjohnson5]

Here is a study on pubmed dealing with men who have erectile dysfunction
http://www.ncbi.nlm.nih.gov/entrez/..._uids=16728967&query_hl=1&itool=pubmed_docsum

The problem is that elevated prolactin lowers testosterone secretion. So men with elevated prolactin are probably in the ED group discussed in the study.

In other words if you are suffering from ED due to elevated prolactin , then yes , dostinex may be exactly what you need. If you DO NOT have elevated prolactin, lowering it further probably won't help your sexual function

 

[todoveritas]

Progesterone is NOT a precusor of Prolactin. It is, however, a precusor to all steroid hormones including estrogen and testosterone. As is usually the case, the estrogen and the excess test that aromatizes to estrogen is the mechanism responsible for gyno. Anybody claiming to truly know the hormonal mechanism responsible for decreased libido, PLEASE tell the medical community bc they are desperately in need of your knowledge. BTW, good post by Johnson.

 

[solidspine]

Dosinex

Test
Fina
Deca

and great sex --------------cool

 

[nydj66]

The prevailing theory is that deca and tren stimulate progesterone receptors directly which leads to an increase in prolactin levels. If this is the case then it still makes sense to take dostinex with these compounds in order to combat the sexual sides and prevent prolactin from aggravating gyno.

Incidentally, increased estrogen can also lead to an increase in prolactin.

 

[chazk]

yes its a double edged sword.

studies do show men with elevated prolactin do have sexual disfunction and surpressed hpta....

men that have to low prolactin levels can cuase the same effect lower sexual drive loss of muscle and libido and ofcoarse surpressed testosterone..

the right balance of prolactin is key ... to much your screwed to little your screwed...
doctors can do a simple test of the pituitary gland output of prolactin to see if your producing to much ...

to much prolactin dostenex /broc can help bring you down to the normal level.....

if the doctor can confirm the prolactin levels are normal no need to surpress prolactin if you do it will only lead to sexual disfunction testoterone surpression ,baldness as well has prolactins surpressed effect on the putuitary will cuase a lower LH and HGH output....

This is the reason why alot of guys with no prolactin issues run dostin and feel libido drop they are cuasing the putuitary gland slow down androgen uptake,surpress the hpta system totally as well as lower Lh and HGH output.

i have a interesting thread I started about why you should never run prolactin inhibators every cycle. Unless its needed .If you do you will do more damage to the hpta shutting it down harder then with just the steroids alone.

the ross has tried stepping on the thread with his studies done with golden hamsters breeding,lab rats and castrated hamsters .No one cares about what happens to a hamster missing his nutsack.claiming that prolactin needs to be reduced to nothing during a cycle in humans is utter hogwash and he has no provided proof to back up his theory that " no prolactin tricks the body into not shutting down the hpta"

The info released in human studies proves reducing prolactin to low cuases all the same side effects of having prolactin to high.
You need prolactin just not to much or to little..lowing it to nothing would cuase loss of muscle ,downregulation of androgen uptake,sexual disfunction and even bladness...

please go to my other thread for a link to the human studies posted by yellow jacket on another forum. Or if you wish to live in a fairtale land like other people goto the ross's thread and read up on lab rats and castrated hamsters..

 

[Ross]

REDUCING PROLACTIN TO SUBNORMAL LEVELS WHILE ON CYCLE WILL DESENSITIZE THE HPTA. This means LESS HPTA suppression.

 

[whackjob]

Food for thought:




Dostinex can damage Heart valves

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Parkinson's Drugs Can Damage Heart Valves
01.03.07, 12:00 AM ET

WEDNESDAY, Jan. 3 (HealthDay News) -- Two drugs commonly used to treat Parkinson's disease can cause harm to heart valves, according to two studies in the Jan. 4 New England Journal of Medicine.

The drugs, pergolide and cabergoline, are both from a class of medications called "ergot-derived dopamine receptor agonists." Ergot is a fungus, and ergot-derived drugs are used not only in the treatment of Parkinson's but also for restless leg syndrome and migraine headaches.

Ergot-derived dopamine receptor agonists were also in the now banned diet drug Fen-phen -- also associated with heart valve disease.

"We uncovered the biomedical reason why Fen-phen had particular side effects on the heart," said Dr. Bryan L. Roth, of the Department of Pharmacology at the University of North Carolina and author of an accompanying journal editorial.

"We evaluated other medications and predicted that they would have the same side effect on the heart," he said. "Our predictions were verified in these two studies."

Based on the new findings, Roth wants the U.S. Food and Drug Administration to look at all drugs that have this side effect with an eye to banning pergolide (brand named Permax) and cabergoline (Dostinex). "This side effect is very dangerous," he said. "It could result in an individual's death or undergoing valve replacement surgery," he added.

These types of drugs interact with a receptor in the heart valve, causing the valve to overgrow and become floppy and leaky, Roth explained.

In the first report, Dr. Edeltraut Garbe, from the Institute of Clinical Pharmacology, Charite, University Medicine, Berlin, and colleagues collected data on more than 11,000 people 40 to 80 years of age who were taking anti-Parkinson's drugs between 1988 and 2005.

The researchers found that, among 31 patients with newly diagnosed cardiac valve problems, six were taking pergolide, six were taking cabergoline, and 19 had not taken any dopamine agonist in the past year.

Almost 30 percent of the patients taking pergolide or cabergoline were at increased risk for heart valve problems.

"In this study, use of the dopamine agonists pergolide and cabergoline was associated with an increased risk of newly diagnosed cardiac-valve regurgitation," the authors concluded.

In the second study, a team of Italian researchers led by Dr. Renzo Zanettini, from the Istituti Clinici di Perfezionamento, Milan, studied 155 patients taking dopamine agonists for Parkinson's disease. Among these patients, 64 were taking pergolide, 49 were taking cabergoline, and 42 were taking non-ergot-derived dopamine agonists. In addition, there were 90 controls.

Zanettini's group found that about 23 percent of the patients taking pergolide had heart valve problems, as did about 29 percent of the patients taking cabergoline.

In contrast, none of the patients taking non-ergot-derived dopamine agonists had a heart problem, while 5.6 percent of the control patients did.

In addition, patients who took higher doses of pergolide or cabergoline had more advanced heart valve disease, the researchers reported.

"The frequency of clinically important valve regurgitation was significantly increased in patients taking pergolide or cabergoline, but not in patients taking non-ergot-derived dopamine agonists, as compared with control subjects," the researchers wrote. "These findings should be considered in evaluating the risk-benefit ratio of treatment with ergot derivatives," they concluded.

"If you have Parkinson's, you need to find out from your doctor if you're taking a medication that could cause this risk of serious heart damage," Roth said. "I would recommend not prescribing these medications at all. Our hope is that these two studies will encourage the FDA to remove these drugs from use."