Though I understand the beauty and reliability of a wheel gun, I also understand how comfortable a slab side is to carry.
Do you live in a state that allows concealed permits?
Are you planning on carrying the weapon a lot or is it just for home protection?
These questions, as well as what brand/model should also be asked IMO...
For home protection, I have a S/W 357 4" revolver with glo sights as well as a mossberg 12 Ga. short stock/barrell with pistol grip.
The riot gun is my best bet at 2 am when it's dark in the house or outside on our property and you are half asleep.
To carry, I love my browning 9mm. Very comfortable
Most everyone has mentioned good weapons in this thread. Buy what feels comfortable to you and meets your needs.