gyno surgery advice.. please respond. (or if you know a lot.. Ulter?Macro?)

[Dial_tone]

Research proves ...Letrozole reverses GYNO

J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):27-34. Aromatase overexpression transgenic mice model: cell type specific expression and use of letrozole to abrogate mammary hyperplasia without affecting normal physiology.

Mandava U, Kirma N, Tekmal RR.

Department of Gynecology and Obstetrics, Emory University, 4217 Woodruff Memorial Building, 1639 Pierce Drive, Atlanta, GA 30322-4710, USA.

Our recent studies have shown thatoverexpression of aromatase results in increased tissue estrogenic activity and induction of hyperplastic and dysplastic lesions in female mammary glands and gynecomastia and testicular cancer in male aromatase transgenic mice. Both aromatase mRNA and protein are overexpressed in transgenic mammary glands and its expression is not limited to epithelial cells. However, it is more in epithelial than in stromal cells.Our results also indicate aromatase overexpression-induced changes in mammary glands can be abrogated [destroyed] with very low concentrations of the aromatase inhibitor, letrozole. Low concentration of letrozole had no effect on normal physiology as indicated by no significant change in the circulating levels of estradiol and follicle stimulating hormone as well as no change in estrogen responsive genes such as the progesterone receptor and lactoferrin in the uterine tissue. These observations indicate that the expression of aromatase in both epithelial and stromal cells can influence the complex interactions of biochemical pathways leading to mammary carcinogenesis and that the aromatase inhibitor, letrozole can be used as chemopreventive agents without affecting normal physiology.

 

[iHulk]

ericahls

How much SUS did you do that caused the gyno?

 

[AAP]

How will nolvadex get rid of a solid lump? This isn't just swelling or puffiness. It is a hard lump. This is fibrious tissue. Nolvadex works on that?

 

[ericahls]

How will nolvadex get rid of a solid lump? This isn't just swelling or puffiness. It is a hard lump. This is fibrious tissue. Nolvadex works on that?

Absolutely not. Fibrous tissue which is what I had will NOT go away. It MUST be surgically removed.

 

[ericahls]

ericahls

How much SUS did you do that caused the gyno?

I was on 500mg/week but I don't think it was the sust I am sure it was the drol. 4 a day will do a number on you.

 

[iHulk]

shoots.. thanks... I've taken 500mg/wk for up to 10 wks on 2 different cycles and got a lot of swelling but thankfully no gyno... but I think about it all the time...

 

[ericahls]

shoots.. thanks... I've taken 500mg/wk for up to 10 wks on 2 different cycles and got a lot of swelling but thankfully no gyno... but I think baouyt it all the time...

And remeber I wasn't taking any anti-e at the time, Yes I was a newbie once.

 

[iHulk]

I hear that. My first 2 cycles... I did virtually zero PCT at all. I don't want to get off topic but speaking of Anti-E. Has anyone used Ancillary guys to get their PCT?

 

[cobra1414]

Absolutely not. Fibrous tissue which is what I had will NOT go away. It MUST be surgically removed.

Word. I've tried all that shit. There isn't a drug on the planet that will make true fibrous gyno disappear.

Except maybe that shit thats used to break up tumors but thats too extreme for my liking.

 

[Ulter]

Breast. 2004 Feb;13(1):61-5.

Management of physiological gynaecomastia with tamoxifen.

Khan HN, Rampaul R, Blamey RW.

Professorial Unit of Surgery, Department of Surgery, Nottingham City Hospital, Nottingham NG5 1PB, UK.

AIMS: We aimed to confirm suggestions that tamoxifen therapy alone may resolve physiological gynaecomastia. METHODS: A prospective audit of the outcome of tamoxifen routinely given to men with physiological gynaecomastia was carried out at Nottingham. Men referred with gynaecomastia had clinical signs recorded, e.g., type (diffuse 'fatty' or retro-areolar 'lump'), size and possible aetiology. They were offered oral tamoxifen 20mg once daily for 6-12 weeks. On follow-up patients were assessed for complete resolution (CR), partial resolution where patient is satisfied with outcome (PR) or no resolution (NR). Success was either CR or PR. RESULTS: Thirty-six men accepted tamoxifen for physiological gynaecomastia. Median age was 31 (range 18-64). Tenderness was present in 25 (71%) cases. Sixteen men (45%) had 'fatty' gynaecomastia and 20 had 'lump' gynaecomastia. Tamoxifen resolved the mass in 30 patients (83.3%; CR=22, PR=8) and tenderness in 21 cases (84%; CR=0, PR=0). Lump gynaecomastia was more responsive to tamoxifen than the fatty type (100% vs. 62.5%; P=0.0041). CONCLUSIONS: Oral tamoxifen is an effective treatment for physiological gynaecomastia, especially for the lump type.



: Int J Adolesc Med Health. 2003 Oct-Dec;15(4):359-63. Related Articles, Links

Tamoxifen treatment for pubertal gynecomastia.

Derman O, Kanbur NO, Kutluk T.

Section of Adolescent Medicine, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Ankara-Turkey. [email protected]

We evaluated the efficacy of the tamoxifen treatment in 37 patients with pubertal gynecomastia. All had distinct, easily palpable breast swellings with a diameter of over three cm. Pain, tenderness, and swelling associated with gynecomastia were reported by six patients. Eight of the patients were obese. One patient also suffered from varicocele. Pain and size reduction was seen in all patients with tamoxifen treatment. No long-term side effects of tamoxifen were observed. The dose of tamoxifen was increased in three patients due to poor response. Two of the treatment group had recurrence problem at follow-up. We did not need to refer any patient to surgery. Tamoxifen treatment is relatively non-toxic, may be beneficial and we think it should be considered for pubertal gynecomastia.