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needtogetaas
New member
dosteov said:
Skin is the optimum site for delivery of the hormones and flavonoids contained in Dermacrine and is far superior to any oral pill or liquid.
Here's why:
Studies with un-methylated hormones such as DHEA and pregnenolone show poor oral bioavailability of about 3% compared to 30-40% when administered topically (3,4). Even if the oral dose is high, the digestive system still lacks the enzymatic activity to convert DHEA to its more active metabolites (e.g. 7alpha DHEA, 7keto DHEA, androstenediol, androstenetriol, androstenedione, testosterone, ect.) It is these metabolites that are responsible for the muscle building, immune stimulating, cortisol blocking, and fat burning effects of DHEA (5-8). In order for DHEA to convert to its active metabolites it must reach its "target organs" such as the adrenals and testis to interact with the appropriate enzymes. Fortunately, the skin contains a high concentration of these steroidogenic enzymes necessary for the conversion of DHEA to its active metabolites (9-15).
Aromatase inhibitors such as chrysin, 7,8 benzoflavone and resveratrol have been shown to have very poor oral bioavailability due to low intestinal absorption, extensive hepatic metabolism, and rapid elimination (1,2). This can explain the lack of "real world" results seen from oral chrysin supplements intended to reduce estrogen(16). Fortunately, these flavonoids have a very low molecular weight, allowing them to easily pass through the skin and reach the blood stream.
Enhancing the bioavailability of the active ingredients through our exclusive topical delivery system dramatically increases their physiological value and opens a new era for "dietary supplement" efficacy. We achieved this by designing the most cutting edge topical formula on the market; the OHV topical delivery system.
The skin can be described by three main layers: The epidermis (top layer), dermis and hypodermis (lower layer). The upper most layer of the epidermis is called the stratum corneum. The stratum corneum is a layer of dead compacted skin cells with a "waxy" texture which poses as the main barrier-to-entry for the skin. Therefore a dynamic transdermal carrier must be used for aggressive delivery of active ingredients. Our transdermal formula offers maximum delivery of active ingredients by utilizing the OHV system - Occlusion, Hydration, and Vasodilation.
* Occlusion - We create this occlusive layer with an invisible acrylic acid polymer. An occlusive barrier causes the skin temperature to slightly increase. This enhances the kinetic energy and "movement" of nutrients across the skin. Increased skin temperature can also help open sweat glands and hair follicles. Opened sweat glands and hair follicles give way to entry deep within the skin for delivery of the active ingredients.
* Hydration - High quality moisturizers and emollients are used to enhance skin hydration. Enhancing hydration helps "swell" and "soften" the skin for increased permeation of active ingredients. Penetration is further increased by including a light weight cosmetic oil derived from shark livers called squalane. Squalane oil mimics and merges with the skins natural sebum, and penetrates the skin incredibly well. This deep penetrating action of squalane carries the fat soluble active ingredients further into the skin.
* Vasodilation - Vasodilators are used to increase blood flow to the skin's surface by opening the local blood capillaries. The increased blood flow helps carry active ingredients away from the skin and into systemic circulation. Caution: Vasodilation is created by ingredients also known to increase photosensitivity, and may temporarily enhance the skins sensitivity to sunlight.
Our proprietary OHV blend safely optimizes delivery of the active ingredients through the skin. This is accomplished without any uncomfortable skin irritation, unpleasant odor, or residue. Rest assured that you are using the most scientifically advanced transdermal formula with the safest and highest quality ingredients.
For those interested in adding there own ingredients to our topical, we sell an "empty" OHV solution as stand alone product. See product page for more information.
Only apply the product to clean, dry skin. Apply product in the morning at least 8hr before bedtime to avoid insomnia. Wash hands after applying the product and avoid product contact with eyes, mouth and genitals.
Use Dermacrine everyday for 2-4 weeks. We recommend taking equal time off between each cycle. For example: Use product 4 weeks, take 4 weeks off, and then repeat.
If using the trigger sprayer - Spray 30-50 spray pumps in hand and apply to the illustrated application area. We recommend this pump during travel to avoid leakage.
If using the lotion pump - Pump 4-6 pumps in hand and apply to the illustrated application area. We recommend this pump for fastest application, however pump may leak during travel.
For best results: Shower and exfoliate skin with body-scrubber to remove dead skin cells. When applying product, spread across skin quickly to cover as much surface area as possible before product dries. Shaving the skin is recommended, but not required.
Remember: Dermacrine's topical formula contains ingredients that temporarily increase photosensitivity (3-4hr) and increase chance of sunburn. Therefore, caution is advised for those applying the product immediately before direct sun exposure.
the skin on the upper chest,shoulders and upper back are optimal because
Opened sweat glands and hair follicles give way to entry deep within the skin for delivery of the active ingredients. were you sweat is were your skin is the most open.
also because these areas of the body are easy to cover up then say the forearms were putting it on areas like this will cause contact with others.
