Yes, Dermacrine can eventually be suppressive, that’s why we say to only use it for 4 weeks, while taking equal time off.
We don’t really promote Dermacrine for PCT - post cycle therapy - anymore because it can become suppressive with the high levels of DHEA and Pregnenolone. But it is a good cycle finisher, and a good way to bridge to Sustain at the end of a cycle.
BTW, we do recommend running the Sustain as long as you like. There really would be no reason to cycle it since it has nothing suppressive about it, and it’s never overly-suppressed estrogen levels.
-Pp