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Class-I & II, why?
- Thread starter Weam
- Start date
PimpnAintEasy
New member
Here's an excerpt from a post on Anabolic Extreme that touches on this:
Blade Stack Guide V1.1-bulking/cutting suggestions
Let's roughly classify steroids in two ways - Androgen Receptor (AR) mediated, and non-AR mediated. AR-mediated action occurs on the cellular level, affecting DNA transcript thus stimulating growth. Non-AR mediated mechanisms are various (and some are not understood yet), but one would be inhibiting the effects that glucocorticoids have upon muscle tissue. In other words, they prevent glucocorticoids from increasing glutamine synthetase and causing muscle tissue breakdown. This would be an anti-catabolic activity.
So first of all you want a steroidal compound that binds to the AR, such as Testosterone, Deca, Trenbolone etc. Their affinity or binding to the AR is different, making Deca and Tren more effective at the AR on a mg per mg basis than Testosterone. My view is that 500mg/week alone of Testosterone will not even be close to saturation of the receptor, so let's consider this for a second…The number of receptors is related to genetics and muscle mass, so someone 300lbs would need more
than a 200lbs guy to saturate the receptors, right? here is also evidence that high levels of androgens
in the body, upregulates or sensitizes the receptor, as will some steroids (which make some stacks more efficient than others), and of course heavy weight training - IMPORTANT! This last issue is the reason why you should probably train for a few years to get closer to what you can achieve naturally, since this will make more AR available for growth potential.
You can not argue with 1000mg of Testosterone being more effective than 500mg, even in beginners. And the fact is that your 1st, or virginal cycle will be your best one since you are further away from your genetic potential than someone with a few cycles under his belt. Saying that you should limit dosage on your first cycle for allowing higher dosage in later cycles just doesn't sound right to me - after all, a gram a week would get you faster to your genetic potential if you're not already there. Going beyond this level, however - say someone who is 40lbs over what he could achieve naturally - would need this much just to sustain what he already has. But his receptors will also be more sensitized and upregulated both due to more muscle mass, more training, and higher levels of androgens in his body on previous cycles. This will make it both more effective - as well as possible - to go with higher dosages. I find that in the long term, after ending drug use, he'll end up splitting the difference between his drug-assisted peak and what he could have achieved naturally. He'll be able to maintain at least 1/3 and probably 1/2 of his gains. This is probably due to increased nucleation of muscle cells and to differentiation of satellite cells into mature muscle cells. Both these changes are permanent and, in my opinion, give a lasting advantage to the athlete.
The KISS principle (Keep It Simple Stupid) is hard to contradict, since a gram a week of T will probably give the greatest gains via AR-mechanism, and some additional non-AR mediated effects. Of course, adding in another AR-agonist like Deca at 400mg/week (which I consider close to maximum considering progesteronic activity), with somewhat higher affinity for the AR - you reduce the dosage of T. Deca, of course, doesn't aromatize much - but you still get water-retention due to it's progestronic activity. You can reduce this by using Winstrol, which appears to block this effect almost entirely. Deca is also known for being good for the joints. That being said - I personally stay away from Deca for various reasons:
1. Although being a more potent AR-agonist than Testosterone, it is only considered half as effective on a mg per mg basis. This is most likely due to its lack of non-AR mediated mechanisms which Testosterone have. Stacking with D-bol and/or Winstrol is a good idea.
2. An important non-AR mediated mechanism is Central Nervous System (CNS) stimulation, which Deca lacks - something that is most noticeable in erection problems commonly known with it. This would also make it a poor 'strength' drug (although I don't like that term too much). Most definitely stack it with Winstrol, Test or D-bol for this reason alone.
3. It is notorious for its detectability on drug tests up to a year after use.
I would rather prefer stacking Testosterone (if at 500mg/week) with Trenbolone at 75-100mg/EOD. Maybe adding some Dianabol here (which works primarily via non-AR action) gives a great stack - at 40-50mg/day in divided dosages. D-bol also works synergistically with both Testosterone and Deca, but limit its use to 4 weeks since it is 17 alpha alkylated and will be toxic to the liver.
Blade Stack Guide V1.1-bulking/cutting suggestions
Let's roughly classify steroids in two ways - Androgen Receptor (AR) mediated, and non-AR mediated. AR-mediated action occurs on the cellular level, affecting DNA transcript thus stimulating growth. Non-AR mediated mechanisms are various (and some are not understood yet), but one would be inhibiting the effects that glucocorticoids have upon muscle tissue. In other words, they prevent glucocorticoids from increasing glutamine synthetase and causing muscle tissue breakdown. This would be an anti-catabolic activity.
So first of all you want a steroidal compound that binds to the AR, such as Testosterone, Deca, Trenbolone etc. Their affinity or binding to the AR is different, making Deca and Tren more effective at the AR on a mg per mg basis than Testosterone. My view is that 500mg/week alone of Testosterone will not even be close to saturation of the receptor, so let's consider this for a second…The number of receptors is related to genetics and muscle mass, so someone 300lbs would need more
than a 200lbs guy to saturate the receptors, right? here is also evidence that high levels of androgens
in the body, upregulates or sensitizes the receptor, as will some steroids (which make some stacks more efficient than others), and of course heavy weight training - IMPORTANT! This last issue is the reason why you should probably train for a few years to get closer to what you can achieve naturally, since this will make more AR available for growth potential.
You can not argue with 1000mg of Testosterone being more effective than 500mg, even in beginners. And the fact is that your 1st, or virginal cycle will be your best one since you are further away from your genetic potential than someone with a few cycles under his belt. Saying that you should limit dosage on your first cycle for allowing higher dosage in later cycles just doesn't sound right to me - after all, a gram a week would get you faster to your genetic potential if you're not already there. Going beyond this level, however - say someone who is 40lbs over what he could achieve naturally - would need this much just to sustain what he already has. But his receptors will also be more sensitized and upregulated both due to more muscle mass, more training, and higher levels of androgens in his body on previous cycles. This will make it both more effective - as well as possible - to go with higher dosages. I find that in the long term, after ending drug use, he'll end up splitting the difference between his drug-assisted peak and what he could have achieved naturally. He'll be able to maintain at least 1/3 and probably 1/2 of his gains. This is probably due to increased nucleation of muscle cells and to differentiation of satellite cells into mature muscle cells. Both these changes are permanent and, in my opinion, give a lasting advantage to the athlete.
The KISS principle (Keep It Simple Stupid) is hard to contradict, since a gram a week of T will probably give the greatest gains via AR-mechanism, and some additional non-AR mediated effects. Of course, adding in another AR-agonist like Deca at 400mg/week (which I consider close to maximum considering progesteronic activity), with somewhat higher affinity for the AR - you reduce the dosage of T. Deca, of course, doesn't aromatize much - but you still get water-retention due to it's progestronic activity. You can reduce this by using Winstrol, which appears to block this effect almost entirely. Deca is also known for being good for the joints. That being said - I personally stay away from Deca for various reasons:
1. Although being a more potent AR-agonist than Testosterone, it is only considered half as effective on a mg per mg basis. This is most likely due to its lack of non-AR mediated mechanisms which Testosterone have. Stacking with D-bol and/or Winstrol is a good idea.
2. An important non-AR mediated mechanism is Central Nervous System (CNS) stimulation, which Deca lacks - something that is most noticeable in erection problems commonly known with it. This would also make it a poor 'strength' drug (although I don't like that term too much). Most definitely stack it with Winstrol, Test or D-bol for this reason alone.
3. It is notorious for its detectability on drug tests up to a year after use.
I would rather prefer stacking Testosterone (if at 500mg/week) with Trenbolone at 75-100mg/EOD. Maybe adding some Dianabol here (which works primarily via non-AR action) gives a great stack - at 40-50mg/day in divided dosages. D-bol also works synergistically with both Testosterone and Deca, but limit its use to 4 weeks since it is 17 alpha alkylated and will be toxic to the liver.
Last edited:
liftingnjuicing
New member
I really think you are confusing the 17-aa alkylated metylation with the metyl group in eq and dbol. I think that these are different methyl groups. Dbol and eq are different roids after all, not just the same one with the 17-aa alkylation and one without. A metyl group is any single carbon chain with hydrogens surrounding it.
Weam
New member
what do you mean by that, also Reforvit is D-bol, and Ref is 17AA Steroid and it's D-bol after allDCS said:
Dynabolon is Nandrolone(Deca) and the chemical name is absolutely diiferent 17-b-Hydroxyestra-4-ene-3-one the parent hormone is Estraeneone
Thanks everybody, I just realized that it was a mistake to assume that the non-methylated version of a steroid
shares the same pharmacological properties as the parent 17alpha-methyl compound.
Scott Steinner
New member
another great post......
I wanna know where the hell has weam gone, and why doesn't he get back here asap?
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