Please Scroll Down to See Forums Below hey guys ive recently found out that i have a double dose of the blood clotting disorder Factor 5 Laeden (double dose meaning both my parents have the gene). The doc obviously told me steroids are bad and never to take them but that is what i expected him to say. i am planing on starting a cylcle in the comming months but am not sure how to go about it with this problem and what would be apropriate to take, any ideas or knowledge would be awsome thanx!
blood clotting.
- Thread starter vosko
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Stocks_and_Steroids
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Take a low dose Aspirin before bed everynight is one thing I do. Others may have other ideas
mikevegas
New member
A: Physiological testosterone replacement therapy does not appear to increase the risk for blood clots.
1. Physiological (low dose) testosterone replacement Physiological testosterone replacement does not adversely
affect blood coagulation status (reference 1) and does not appear to lead to an increased risk of venous or arterial
thrombosis. Thrombosis is not listed as a potential side effect in drug compendiums on and package inserts of
testosterone. Furthermore, a 2006 "Clinical Practice Guideline" (ref. 2) also does not list thrombosis as a side
effect of testosterone replacement therapy, or a previous history of thrombosis as a reason to not give testosterone
replacement therapy.
2. Anabolic steroids in athletes Anabolic steroids are chemical variants of testosterone. They are taken in various
doses, typically by athletes, to enhance muscle mass and physical performance. Several cardiovascular
complications have been reported to occur in people using anabolic steroids, including high blood pressure,
stroke, heart attacks (myocardial infarction), and pulmonary embolism (reference 1). It is impossible to get a real
sense of how frequent these complications occur, as it is difficult to find athletes for cardiovascular investigations
who admit that they have taken anabolic steroids. Anabolic steroids taken long-term may increase the risk for
arteriosclerosis (= hardening of the arteries), because they change the metabolism of blood lipids: the bad
chlolesterol LDL increases and the good cholesterol HDL decreases (ref. 3). Anabolic steroids may also lead to
increased blood clot formation, even when taken only short-term, because they (a) increase the level of clotting
factors (= pro-coagulant factors), (b) decrease levels of the blood clot-dissolving proteins (= fibrinolytic proteins)
that we all have, and (c) make blood platelets more sticky (= lead to increased platelet aggregation) (ref. 4).
References:
1. Smith AM et al. Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and
plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina. Eur J Endocrinol. 2005
Feb;152(2):285-91.
2. Bhasin S et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society
clinical practice guideline. J Clin Endocrinol Metab.2006 Jun;91(6):1995-2010. Erratum in: J Clin Endocrinol
Metab 2006 Jul;91(7):2688.
3. Glazer G. Atherogenic effects of anabolic steroids on serum lipid levels. Arch Intern Med 1991;151:1925-33.
4. Ferenchick GS. Anabolic-androgenic steroids and thrombosis: is there a connection? Med Hypothesis 1991;
1. Physiological (low dose) testosterone replacement Physiological testosterone replacement does not adversely
affect blood coagulation status (reference 1) and does not appear to lead to an increased risk of venous or arterial
thrombosis. Thrombosis is not listed as a potential side effect in drug compendiums on and package inserts of
testosterone. Furthermore, a 2006 "Clinical Practice Guideline" (ref. 2) also does not list thrombosis as a side
effect of testosterone replacement therapy, or a previous history of thrombosis as a reason to not give testosterone
replacement therapy.
2. Anabolic steroids in athletes Anabolic steroids are chemical variants of testosterone. They are taken in various
doses, typically by athletes, to enhance muscle mass and physical performance. Several cardiovascular
complications have been reported to occur in people using anabolic steroids, including high blood pressure,
stroke, heart attacks (myocardial infarction), and pulmonary embolism (reference 1). It is impossible to get a real
sense of how frequent these complications occur, as it is difficult to find athletes for cardiovascular investigations
who admit that they have taken anabolic steroids. Anabolic steroids taken long-term may increase the risk for
arteriosclerosis (= hardening of the arteries), because they change the metabolism of blood lipids: the bad
chlolesterol LDL increases and the good cholesterol HDL decreases (ref. 3). Anabolic steroids may also lead to
increased blood clot formation, even when taken only short-term, because they (a) increase the level of clotting
factors (= pro-coagulant factors), (b) decrease levels of the blood clot-dissolving proteins (= fibrinolytic proteins)
that we all have, and (c) make blood platelets more sticky (= lead to increased platelet aggregation) (ref. 4).
References:
1. Smith AM et al. Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and
plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina. Eur J Endocrinol. 2005
Feb;152(2):285-91.
2. Bhasin S et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society
clinical practice guideline. J Clin Endocrinol Metab.2006 Jun;91(6):1995-2010. Erratum in: J Clin Endocrinol
Metab 2006 Jul;91(7):2688.
3. Glazer G. Atherogenic effects of anabolic steroids on serum lipid levels. Arch Intern Med 1991;151:1925-33.
4. Ferenchick GS. Anabolic-androgenic steroids and thrombosis: is there a connection? Med Hypothesis 1991;
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