No, unless the aesthetics matter to you.
My biceps shrink slightly when I ignore them, which is most of the time. They come back so quickly, though, when I work them that it's completely irrelevant to me that they shrink slightly. I can have them back within a couple of weeks and for what? Just so that I can ignore them again?
I haven't done direct biceps work since March and that was just during some time between programs and switching gyms. It's a small muscle group which gets all it needs from the other exercises. I'd rather work forearms than spend time on biceps.