His comments where a cut and paste from a t-nation thread, one that, like many threads jumps to a lot of conclusions. However, correlation does not equal causation. Its been a while since I did some serious digging and reading on receptors but from what I recall test and estradiol use completely different receptors so unless someone can show more than some T-nation forum ramblings I dont buy it at all.
Lets look at things logically for a second, even IF Estradiol competed for the androgen receptor, for men, typical E lab range is like 7 to 42 where as serum test is 300-900 (some labs as high as 1100).
We are talking about trt doses in the 300mg/wk range which has shown to put serum T around 1300. Most folks who have E thats on the high end of normal usually its due to high bodyfat. Which seems to follow suite here with the OP at 28%.
Now, lets say the OP's T is on the low end at 300 and his E is at the high end. say 40.
Now the op starts 300mg/wk test and his E gets up to say 75 while his T goes up to 1300, can anyone honestly say that say an extra 35pts of E is going to nullify 600 points of T? I seriously doubt it. Could it have some negative impact? Sure but I think the original author of the post that was copied was reaching at straws and overstating the negative effects of E.
Is E of 75 high? Sure, probably a bit higher than you would want it but it certainly isnt going to make your 300mg/wk test worthless.
check out this abstract when you have a second.
Serum estradiol is associated with lean mass in elderly Swedish men -- Vandenput et al. 162 (4): 737 -- European Journal of Endocrinology
hard to draw any real conclusions since you cant read the full study but it certainly shows that one cant simply say E is bad.
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