Alpha Lipoic Acid (ALA)

[Fonz]

I recomend 500mg/day.


Fonz, your previous post is totally ambigious. You claim that I am wrong about something, yet you post ambigious information that sounds good, but doesn't prove your point.

ALA mimics insulin. It works in the same way that insulin does by shuttling glucose into the muscle cells. It doesn't matter if you are a diabetic or not, it works like insulin. There's no difference in the cells of a diabetic and non-diabetic.

That was a very good discription of how insulin works. You sound like you know what you are talking about. You could really make some of the newbies believe you have a degree... But your post is toally ambigious as to any effects of ALA.


-Stew

Stew, you're not the ony person that goes to
University you know. While you are a biochem
graduate(just a guess), I happen to be doing
a masters in Aerospace w/ bio-chem
minor(which I've already completed).
Now, if you want to discuss matter-anti-matter,
ion, Fusion etc... spacial propulsion systems
be my guest as I'll just end up embarrassing
you.
Your back-ground in bio-chem is more advanced
than mine, but that doesn't make me stupid.
Furthermore, most of the b-chem discussed
here is pretty basic, and I do have the necessary
qualifications to give advice.

In reference to my ambiguity:

Cockedzl summed it up.
You specified that ALA increased glucose
transport primarily into the muscle
cells. THIS IS INCORRECT. it increases
transport to both the miocytes and
adipocytes.
He was even nice enough to provide a couple
of studies.

You also forgot to mention the glut-4's action on
insulin sensitivity and the effect ALA has on
them.(It increases their number at the
surface of the cell) WHICH IS EXACTLY
HOW ALA WORKS.

I happen to have wirtten quite a few papers
on diabetes because it fascinates me.
I have also personally used ALA for
quite a few years now.
So Stew, i think you're barking up the wrong
tree on this one.

I'd also follow Cockedzl's advice. 600mg/day
was the amount quoted in the german studies.
ALA is also known as THIOCTIC ACID. Do
a search on that.
(Some studies use this name instead of ALA)
If doing a CKD, 1200-2000mg is optimum for
glucose transport.(From my experience)

Cockedzl, did you happen to come accross
a study that showed that a combination
of GLA+ALA yielded better glucose up-take
than ALA alone? I can't remeber where
I saw it........but it sounded promising.

Godspeed

 

[phiend]

what the fuck??

you guys sound like a bunch of little bitches. quit whining like a bunch of pussies. it pains me to read the post, but i still have to to see what is said next. it's like a frickin soap opera. you guys got me hooked. i feel like a Buffy fan now or something. However, it's annoying the hell out of me at the same time. i haven't learned too much important ALA info on this post, but i have discovered that there's a lot of stubborn people on this board.
I remember when Macrophage used to go on his power trips, but it seems that he has dialed it down a bit and others have taken his throne of bitchdom. Congrats, guys; you are officially little bitches. Thank you, drive thru...

 

[Fonz]

LOL Phiend....

That Buffy reference was funny......LOL

Sorry about the massive argument, but I'll explain
how ALA works for the bodybuilder.

Subject A consumes a diet of 3000Kcal a day.
He follows a regime composed of
60% carbs/30%protein/10%fat. In other words
a typical BB regimen.

Thats;

Kcas=3000
Carbs=1800/4=450g
Protein=900/4=225g
Fat=300/9=33g

Now, his muscles are capable of holding
375g of glycogen. He however is eating
450g. Thats 75g too many(300Kcal),
an after 12 days on this diet he will
pick up 1lb of fat.

Now, lets add 600mg ALA/day in divided doses.

ALA will increase glucose up-take into the muscles by
roughly 40%.


His muscles were capable of holding 375g of carbs but
now due to the ALA they can hold:
375g+(375*0.4)=525g of carbs.
So now, he is consuming 450g of carbs and is capable
of storing 525g of carbs.
(A deficit of 75g or 300Kcal)


By adding some cardio at 60-70% intensity for 45min
(around 300Kcal caloric expenditure), he now
loses 1lb of fat every 12 days, instead of gaining
1lb of fat.

Do you now see the benefit of ALA?

Its an excellent supplement in my opinion.

Godspeed

 

[Mass Monster]

Fonz good info, you guys just keep going at it

Mass Monster

 

[Verbal Gorilla]

So ALA would be perfect with GH due to increase of GLUT4 pathways...

 

[Fonz]

Yes VG. ALA would overcome GH-induced insulin
resistance.
Another drug whuch overcomes GH-induced
insulin resistance is TROGLITAZONE.
Another diabetic drug.

Godspeed

 

[WonderWoman]

Okay, now I get it. ALA allows me to have a calorie deficit at a higher level. Thereby assisting me with maintaining adequate caloric intake to be muscle sparing, yet allowing me to still be in enough calorie debt to enhance fat loss. I also understand that 600mg/day divided equally would be optimum dosage.
Again thanks gentlemen
WW

 

[lawnsaver]

Fonz, what would you say is more effective, ala or metaformin hcl? They do similar things, correct?

 

[Zeke_B]

Thanks for the posts, Fonz. You guys produce a lot of good info when you are pissed off. In you guys' opinions, are there any down sides to ALA supplementation other than the cost. Are there sides, resistance build-up, or backlash when one comes off? Do you cycle or take continuously forever?

 

[Rockaho]

I'm still a bit confused.


"ALA will increase glucose up-take into the muscles by
roughly 40%."


"By adding some cardio at 60-70% intensity for 45min
(around 300Kcal caloric expenditure), he now
loses 1lb of fat every 12 days, instead of gaining
1lb of fat."


I have been told that I have to use/burn off the gluecose befor I begin to burn fat. If this is true it looks like I have to do extra cardio because I took ALA. This obviously isn't how it works so please explain.