cockdezl said:"I don't think anyone has ever studied or characterized a 1,2-reductase, at least not in humans. 1,2 unsaturated steroids are very rare in mammals, although microbes seem to make them pretty easily. All we know is that the 1,2 double bond of 1-test and 1-AD is definitely reduced in-vivo by some sort of process. "
Any possibility this may be due to entero-hepatic recycling?
I don't think so because a much larger portion of the 1-test (majority of it) gets reduced than you would expect from this route alone (which is a very minor physiological pathway). Good thinking though to suggest this