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Research Chemical SciencesUGFREAKeudomestic
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You recommended Toremifene as a better substitute for Nolvadex, but I was researching that and found the following study which doesn't look to promising as a nolva replacement. What are your thoughts? Thanks


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Cancer Chemother Pharmacol. 2000;45(5):402-8. Related Articles, Links
Dose-dependent hormonal effects of toremifene in postmenopausal breast cancer patients.

Ellmen J, Werner D, Hakulinen P, Keiling R, Fargeot P, Falkson G, Bezwoda WR.

Orion Corporation, Orion Pharma, Clinical R & D, Turku, Finland. [email protected]

PURPOSE: The purpose of the study was to compare hormonal effects of three toremifene doses, 20 mg (TOR20), 40 mg (TOR40) and 60 mg (TOR60) administered daily, in postmenopausal women with advanced breast cancer. METHODS: The study was randomized and open label in three parallel groups. Biochemical variables were identified as the serum concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH) and sex hormone binding globulin (SHBG). The changes were compared with objective clinical responses and to progression-free time. Adverse reactions and liver function test (aspartate aminotransferase, ASAT) were assessed for safety. RESULTS: A total of 260 patients were randomly grouped (90 to TOR20, 81 to TOR40 and 89 to TOR60). Of these patients 29, 29 and 22 completed at least 3 months of treatment and the results were analyzed for biochemical variables. All treatments had intrinsic estrogen agonist activity by decreasing of serum FSH and LH and by increasing of SHBG during the first 3 months (P < 0.01). Dose TOR20 showed slightly longer times to exert maximum estrogenic effects than did the two higher doses. No increases in liver function tests were seen in any of the groups. Objective response rates were 24.4, 39.5 and 32.6% (P = 0.01) and median times-to-progression were 206, 189 and 196 days in TOR20, TOR40 and TOR60, respectively (P = 0.913). Fewer responses were observed in the TOR20 group than in TOR40 (P = 0.05). Adverse events were reported in 19, 23 and 30 patients in the treatment groups (P = 0.20). The most frequently reported events were hot flushes and nausea. These were mostly mild or moderate, and only 1.5% of treatments was discontinued due to toxicity. CONCLUSIONS: Toremifene doses of 40 and 60 mg daily were effective and safe treatments of breast cancer in postmenopausal women, and no differences in their biochemical or clinical effects were seen. Toremifene at 20 mg/day had similar but slightly less potent antiestrogenic and estrogenic effects than the two higher doses.

Thats the expected effect in women. SERMs have the opposite effect in men. (increase LH/FSH/Testosterone)

-Eric
 
With this PCT, there will be a rapid increase in LH, FSH, and testosterone, as well as almost a complete block on all the factors that could be causing your natural hormones to be delayed in returning to baseline. For this reason, I feel that the second your cycle is over is when you should start this PCT (a week after your last shot, or the day after your last pill is fine).

Remember, waiting for some of the extra androgens you’ve been taking to leave your body is nonsensical, as we want to start recovery as soon as possible to retain maximum gains. There is no evidence to suggest waiting any length of time after your cycle is over will increase PCT effectiveness…it simply prolongs the time you aren’t doing anything positive to regain your natural hormones. And how long do we run this for? Well…we need to stop the HCG relatively soon for reasons discussed earlier. But the Nolvadex, and Aromasin can be used for awhile longer. Ideally, we’d be getting weekly blood work, but we could also get it done monthly, and just running this

PCT until we see our natural hormones restored…but weekly bloodwork isn’t really an option for most of us. Failing the option of monitoring recovery with blood-work, I’m going to give you my best thoughts on the time you should be running your PCT. It’s important to note I haven’t discussed nutrition or other compounds that may be beneficial…this is because in this article, I am primarily concerned with the restoration of hormonal function, nothing else. And with no further delays, here are my recommendations for PCT ( You can find detailed TABLE in this source: Come OFF Steroids | Anabolic Steroid Articles):
Week Nolvadex HCG Aromasin Vitamin E 1 20mgs/day 500iu/day 20mgs/day 1,000iu/day 2 20mgs/day 500iu/day 20mgs/day 1,000iu/day 3 20mgs/day 500iu/day 20mgs/day 1,000iu/day 4 20mgs/day 20mgs/day 5 20mgs/day 6 20mgs/day
 
Question.....will the test recovery stack still be available after Jan 1st, with that bill being passed? im planning on buying it in the first couple weeks of january to use for PCT.
 
The TRS does not contain any hormone or prohormone. There's nothing to ban on it.
 
Do you need to store oral sustain alpha in the fridge?
 
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