I am wanting to know as well and have been searching all over the net for info. Even with Platinum search I haven't been able to find any solid info or experiences to pull from. The below info is from another board, they are selling the stuff so keep that in mind..
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The (HGH fragment 177-191) is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in a specific and physiological manner. To date studies suggest that (HGH fragment 177-191) has several beneficial features: it reduces abdominal fat (in particular visceral fat), without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile. These characteristics make it an ideal candidate for the treatment of excess abdominal fat, an important aspect of HIV-associated lipodystrophy.
At a dosage of 500mcg the (HGH fragment 177-191) was shown to increase lipolytic activity in adipose tissue. In other words this fragment potently burns body fat, especially the stubborn adipose fat, and it does so potently! Of significance, is that the fragment has no negative impact on insulin sensitivity, a stark contrast from its HGH counterpart. (Ng FM, Sun J,Sharma L, Libinaka R, Jiang WJ, and Gianello R 2000).
Not only does the (HGH fragment 177-191) not interfere with the body’s insulin regulation as Human Growth Hormone can, the (HGH fragment 177-191) does not result in cellular proliferation as its Human Growth Hormone counterpart does. The fragment is similar to Human Growth Hormone, hence the shared amino acid sequence, however, the (HGH fragment 177-191) does not induce hyperglycaemia or reduce insulin secretion. The (HGH fragment 177-191) does not compete for the hGH receptor and nor does it induce cell proliferation, unlike Human Growth Hormone. (Wu Z, Ng FM. 1993). Thusly, this is a very beneficial peptide in terms of burning fat, without side effects.
In yet another study, the (HGH fragment 177-191) exhibits the ability to burn through adipose tissue by increasing lipolytic activity (the breakdown of fat) , in the most stubborn body fat (adipose tissue) while increasing energy expenditure and glucose and fat oxidation in ob/ob mice treated with (HGH fragment 177-191). In addition, (HGH fragment 177-191) increased in vitro lipolytic activity and decreased lipogenic activity in isolated adipose tissue from obese rodents and humans. (Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. 2000).
Thusly, the (HGH fragment 177-191) exhibits the ability to burn through stubborn adipose tissue, while increasing energy expenditure, muscle mass, and fat oxidation. All studies have pointed to the fact that the fragment is an effective treatment for obesity and fat loss, and much safer than its Human Growth Hormone counterpart.
In a recent study the (HGH fragment 177-191) or TH9507 was tested to determine its efficacy in reducing visceral adipose tissue (fat). The study’s goal was an 8 percent reduction in visceral adipose tissue, but the result was a 15 percent reduction, nearly double of what was expected! This study lasted 6 months and was at a dose of 2mg a day, however lower dosages have also been proven to be quite effective.
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