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WHat a wounderful drug gw-501516 is.

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needtogetaas

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GW-501516 is a PPARδ modulator compound is currently being investigated for drug use by GlaxoSmithKline. It activates the same pathways activated through exercise, including PPARδ and AMP-activated protein kinase. It is being trialed as a potential treatment for a few conditions consisting mainly of obesity, diabetes, dyslipidemia and heart disease. GW-501516 has a synergistic effect when combined with the AMP-K agonist AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than 40%. And from My own experience yes it works my friends.

GW-50156 regulates fat burning through a number of different pathways which includes exercise mimetic effects. It increases glycogen retention in skeletal muscle tissue while increasing muscle gene expression. This shift changes the body’s metabolism to allow for more fat burning and for energy instead of carbohydrates or protein as the source of fuel. This is why the main reason why it’s being looked into as a treatment for diabetes. As it will not allow the patients to endure and overly catabolic state, thus allowing energy levels and health to be stable at all times. GW-501516 clearly demonstrates that it increases muscle mass while keeping glucose from touching the adipose tissue sort of like Need2Slin but need2slin does much more then just this. Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. We dive into its attributes further later in the article But again let me speak from personal experience. I did a test with this drug and Winstrol. I know for my self when I take wonstrol it always kills my cholesterol levels. Last time I took it I ended up with an HDL of ten and a LDL over two hundred and it only took less then 2 weeks for this to happen. So knowing this I took wintrol for 4 weeks and also took GW-501516 along with it and I was amazed at the results. My cholesterol levels were BETTER at the end of the 4 week trial. So if cholesterol is of concern for you then you need to get some of this stuff my friend because trust me it works.



- Need To Build Muscle Inc. Official Blog

Read the rest here on my blog^^^^^
Uniquemicals
and get some here ^^^^^
 
is this stuff readily available yet Needto? when where how much???

Uniquemicals <--- you can get it right here man :evil::evil:
Run it 5mg am and 5mg pre work out and make sure you come back here to my thread and post your experience for me man. Help contribute the info to the site for us all. Thanks so much .. I explained my Experience with this drug in the Article I linked too.
 
I have a feeling I will be buying this soon. I like my eggs and red meat... i wonder how i should dose it to my rats tho.
 
defintely want to research this.. i wish there were a few logs up to read about..
 
ive done some googling.. and a few logs just started so id like to see how these go.

this has been around.. or underground and whispered about for a while.. so im curious to see how it plays out now that it is basically in the open.. the endurance benefits are definitely interesting to someone like me :)
 
For the inquisitive testers out there that are are curious... can you run this alongside, say... osta and s4? also, what would the recommended amount of time on this be?

I know there are a lot of people wondering this as well as me! =) It sounds absolutely awesome and I AM STOKED to try it out...

Also, for anyone who wants to try it, along with your other sarms, like ostarine and s4, Uniquemicals is THE PLACE to go... They have tremendous products and THE BEST prices out there... I HIGHLY recommend them!


If you read my Article that I link to it will explain everything for you.. This is why I write :qt:

- Need To Build Muscle Inc. Official Blog

:rose::rose:
 
Is something wrong with the uniquemichals site? I get an error "This website is currently unavailable" and something in the URL about "suspended" when I go there.
 
I have a buddy who is using he was 345lbs before he started this and his diet and now in only a few months he's down to 217.8 as of yesterday he's gona run sarms s-4 and osta sarm with it next and see if he can get to like 185ish he loves it


Go Heavy Or Go Home
 
I have a buddy who is using he was 345lbs before he started this and his diet and now in only a few months he's down to 217.8 as of yesterday he's gona run sarms s-4 and osta sarm with it next and see if he can get to like 185ish he loves it


Go Heavy Or Go Home

thats some serious work there.tell your friend congrats he def earned it
 
Very interesting stuff. I have no personal experience with it but am looking forward to hearing people's evaluations.
 
My GW-501516 has just been shipped ! :) Will post about my experience with it here.


can't wait to hear your thoughts on it.GW is some serious stuff and should def help you reach your goals and more.

keep me posted if you can on how it goes for you
 
I am thinking of trying a GW / s4 cycle before my test E cycle. Thoughts on this to help me harden up like a rock? Anyone stacked these two?
 
I am thinking of trying a GW / s4 cycle before my test E cycle. Thoughts on this to help me harden up like a rock? Anyone stacked these two?

I would suggest your rat try each separate before stacking so your rat can ensure what type of effects he gets from each.

I would suggest s4 for your rat if he is looking for hardness.
 
$99 for 15 days...

What kind of results do we expect to see in what time period? Looks like a very interesting drug indeed.
 
$99 for 15 days...

What kind of results do we expect to see in what time period? Looks like a very interesting drug indeed.

thats the price for the Ostarine .the s4 is 39.before discounts.

strength increase,vascularity ,leaness if your rat is doing the diet thing,alot of rat users talk about how this stuff helped with their rats joints issues even ones they have had for years.
 
thats the price for the Ostarine .the s4 is 39.before discounts.

strength increase,vascularity ,leaness if your rat is doing the diet thing,alot of rat users talk about how this stuff helped with their rats joints issues even ones they have had for years.

Are there any discounts?
 
For the inquisitive testers out there that are are curious... can you run this alongside, say... osta and s4? also, what would the recommended amount of time on this be?

I know there are a lot of people wondering this as well as me! =) It sounds absolutely awesome and I AM STOKED to try it out...

Also, for anyone who wants to try it, along with your other sarms, like ostarine and s4, Uniquemicals is THE PLACE to go... They have tremendous products and THE BEST prices out there... I HIGHLY recommend them!

You can run it with ether. I would run it with S4 25mg twice a day 8 weeks at the least 10mg is my sweet spot with this shit I am using it right now as we speak. Me? O im stacking it with test prop,. tren ace, Var, Provirone, little growth hormone and some peptides.. I did however run it on its own a wile back for a wile to see how it worked.. O shit ya using albutrerol too. LOVE IT!!!
 
LOVE IT!! so here's my plan... im mid pct right now with osta at 25 mg a day... after pct i was going to stack osta and s4, so I am thinking I will add a little gw to the mix... triple sarm stack for a bridge to my next cycle... speaking of bridge, I have a nice fresh NTBM bottle of that to use before my next cycle as well... =)



You can run it with ether. I would run it with S4 25mg twice a day 8 weeks at the least 10mg is my sweet spot with this shit I am using it right now as we speak. Me? O im stacking it with test prop,. tren ace, Var, Provirone, little growth hormone and some peptides.. I did however run it on its own a wile back for a wile to see how it worked.. O shit ya using albutrerol too. LOVE IT!!!
 
LOVE IT!! so here's my plan... im mid pct right now with osta at 25 mg a day... after pct i was going to stack osta and s4, so I am thinking I will add a little gw to the mix... triple sarm stack for a bridge to my next cycle... speaking of bridge, I have a nice fresh NTBM bottle of that to use before my next cycle as well... =)

Yup you can run all that and the bridge to if you like man.
 
my rat is running unique s4 right now solo and my rat is thinking of adding this in down the road once my rat is at super low bf% to see if it will help drop those last few lbs (BIG RAT).

whats the longest anyones rat has run this?
 
$99 for 15 days...

What kind of results do we expect to see in what time period? Looks like a very interesting drug indeed.

how did you get 15 days? I thought it lasted for 30 days...well mine did. I dosed at 5mg though.
 
It is on sale right now.. Also if you are running tren add some of this in and help prevent the shortness of breath tren will give you
 
I am using GW with AICAR,first two weeks just completed, 10mg gw and 25mg aicar each day on my big rat.I know the directions on aicar is every other day but my rat is old so his needs are different.I am also using test cyp.,proviron,anastozole and a little deca for the rats discomfort.Before starting - 6 am fast walk 2 miles, then two hours later 1 hr workout after breakfast in pm cardio 1/2 hr on treadmill. Now,run for two miles and breathing is comfortable.My b.b. workouts are 1 1/2 hrs. 10-12 sets or more for each body part.I am even doing drop sets and feel recuperated 30 seconds after the set.I am doing treadmill for one hour at night and some other cardio for a half hour.Brothers I have lifted weights since I was 14 and am now 63.I had a complete physical with a 7 panel blood testing before starting this.I will have a duplicate test after three months.My rat has lost 6 pounds and that is only because he is eating like a horse.So far I have a lot of energy even if I miss sleep.I do not get a rush of energy,I just keep going.Hope this works for all of you.
 
Once a month, I run this stuff for a week at 20mg a day. It makes a small difference. I might cut my dose in half and run it twice as long to see what happens.
 
my rat is dosing 5mg twice a day and seein nada so far to be honest...I was really hoping for more endurance and it isn't happening, nor is anything else
not sure if I want to add aicar or not
 
So what is the aicar is this something you need to take with it little unclear on this.. Also you suggest 5Mg orally twice a day? Y does.article.say inj this is like cardio? Are you suppose to inj? Would you Stack this with aas cycle.or run when off
 
I am using GW with AICAR,first two weeks just completed, 10mg gw and 25mg aicar each day on my big rat.I know the directions on aicar is every other day but my rat is old so his needs are different.I am also using test cyp.,proviron,anastozole and a little deca for the rats discomfort.Before starting - 6 am fast walk 2 miles, then two hours later 1 hr workout after breakfast in pm cardio 1/2 hr on treadmill. Now,run for two miles and breathing is comfortable.My b.b. workouts are 1 1/2 hrs. 10-12 sets or more for each body part.I am even doing drop sets and feel recuperated 30 seconds after the set.I am doing treadmill for one hour at night and some other cardio for a half hour.Brothers I have lifted weights since I was 14 and am now 63.I had a complete physical with a 7 panel blood testing before starting this.I will have a duplicate test after three months.My rat has lost 6 pounds and that is only because he is eating like a horse.So far I have a lot of energy even if I miss sleep.I do not get a rush of energy,I just keep going.Hope this works for all of you.

Do you inject the aicar IM?
 
I just came across this stuff on another forum. I had never even heard of it. I find it very interesting but didn't know much about the side effects and the dosage? Can anyone chime in on dose and how to start off with it.


GW-501516 is a PPARδ modulator compound is currently being investigated for drug use by GlaxoSmithKline. It activates the same pathways activated through exercise, including PPARδ and AMP-activated protein kinase. It is being trialed as a potential treatment for a few conditions consisting mainly of obesity, diabetes, dyslipidemia and heart disease. GW-501516 has a synergistic effect when combined with the AMP-K agonist AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than 40%. And from My own experience yes it works my friends.

GW-50156 regulates fat burning through a number of different pathways which includes exercise mimetic effects. It increases glycogen retention in skeletal muscle tissue while increasing muscle gene expression. This shift changes the body’s metabolism to allow for more fat burning and for energy instead of carbohydrates or protein as the source of fuel. This is why the main reason why it’s being looked into as a treatment for diabetes. As it will not allow the patients to endure and overly catabolic state, thus allowing energy levels and health to be stable at all times. GW-501516 clearly demonstrates that it increases muscle mass while keeping glucose from touching the adipose tissue sort of like Need2Slin but need2slin does much more then just this. Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. We dive into its attributes further later in the article But again let me speak from personal experience. I did a test with this drug and Winstrol. I know for my self when I take wonstrol it always kills my cholesterol levels. Last time I took it I ended up with an HDL of ten and a LDL over two hundred and it only took less then 2 weeks for this to happen. So knowing this I took wintrol for 4 weeks and also took GW-501516 along with it and I was amazed at the results. My cholesterol levels were BETTER at the end of the 4 week trial. So if cholesterol is of concern for you then you need to get some of this stuff my friend because trust me it works.



- Need To Build Muscle Inc. Official Blog

Read the rest here on my blog^^^^^
Uniquemicals
and get some here ^^^^^
 
Just a question.. due to confusion. Your blog claims injecting? But other sources claim it's taken orally?

Edit: Just went to store to check it out.. it's oral.
 
Just a question.. due to confusion. Your blog claims injecting? But other sources claim it's taken orally?

Edit: Just went to store to check it out.. it's oral.

its taken orally.. stuff is amazing, atleast it was for me.dose it at 20mg a day..Only problem was it ran out pretty fast for me, im waiting for more to come and i cant wait.
 
Just a question.. due to confusion. Your blog claims injecting? But other sources claim it's taken orally?

Edit: Just went to store to check it out.. it's oral.

its taken orally.. stuff is amazing, atleast it was for me.dose it at 20mg a day..Only problem was it ran out pretty fast for me, im waiting for more to come and i cant wait.

here is the best place to buy it-->SARMS SEARCH.COM
 
Isn't this notorious for causing cancer ?Didn't GlaxoSmithKline find that in there studies ?


Jont - Sent from my iPhone
 
Isn't this notorious for causing cancer ?Didn't GlaxoSmithKline find that in there studies ?


Jont - Sent from my iPhone

The dosages in the cancer studies were that of 100-1000 times the normal dose. So, don't do that. Most things can be safe in moderation. Don't abuse
 
The dosages in the cancer studies were that of 100-1000 times the normal dose. So, don't do that. Most things can be safe in moderation. Don't abuse

I believe the cancer studies were at a ridiculous dose of 5mg/kg of bodyweight and for an extended period if time. Like anything, taken in moderation there should be zero issues with GW
 
I believe the cancer studies were at a ridiculous dose of 5mg/kg of bodyweight and for an extended period if time. Like anything, taken in moderation there should be zero issues with GW
Yep, I agree with you Rick... those studies has CRAZY high doses!
 

MK-2866 25mg/day
GW-501516 5mg/twice a day
S-4 25mg/day 5 days on / 2 days off

I used S4 to jumpstart an 8 week MK-2866 + GW-501516 cycle. Dropped the S4 after 10 days. Terrific cycle - all from Uniquemicals.

Uniquemicals = great products and customer service.

Discount code MIM534 will get you 10% off at Uniquemicals
 
Ill be testing this out soon.
My focus is more on endurance than strength or size. I'm excited about the possibilities here.
 
Ill be testing this out soon.
My focus is more on endurance than strength or size. I'm excited about the possibilities here.

What do you do now again? arent you into cross country biking or something now?with the kind of shyt you are into,i am SHOCKED you have not tired this yet..this is the real deal for endurance..you have just found gold, good friend.

get it from sarmsseach also.. they got the super pure gw !
 
Good write up Nathan! Effects on cholesterol are badass, I didn't realize they had this effect. I'll have to run Some SS GW with my dbol cycle... Err, my rat's dbol cycle I mean.
 
What do you do now again? arent you into cross country biking or something now?with the kind of shyt you are into,i am SHOCKED you have not tired this yet..this is the real deal for endurance..you have just found gold, good friend.

get it from sarmsseach also.. they got the super pure gw !

Yeah bro. This weekend I'm doing a road race with ~6000 feet of climbing and next weekend in doing a 100 mile mtb race. I'm pretty much a full blown endurance athlete now. The only strength training I do is body weight and core twice a week. Everything else is done on the bike.

My offseason starts in two weeks. I'm gonna test GW then and decide if it will be a good addition to my training and racing schedule. It looks to be an amazing compound.
 
I wouldn't write off the cancer risk so easily. Sure the rat studies used high doses, but that is pretty typical protocol for drug testing. Rats have short lives and cancer isn't going to show up fast enough unless high doses are used. But the evidence is usually considered translatable.

It sounds like the evidence is pretty strong, and the drug, despite its possible HDL benefits, will never be approved, because of "serious toxicities" and "tests on rats showed that at all doses, the drug rapidly causes cancers in a multitude of organs, including the liver, bladder, stomach, skin, thyroid, tongue, testes, ovaries and womb".

Take that for what its worth. Maybe it causes cancer like saccharin causes cancer (?), or maybe its much worse. I'm just saying you can't come to any conclusion about it being safe by looking at the studies and assuming that the study conditions don't apply to you.
 
Yeah bro. This weekend I'm doing a road race with ~6000 feet of climbing and next weekend in doing a 100 mile mtb race. I'm pretty much a full blown endurance athlete now. The only strength training I do is body weight and core twice a week. Everything else is done on the bike.

My offseason starts in two weeks. I'm gonna test GW then and decide if it will be a good addition to my training and racing schedule. It looks to be an amazing compound.
Bro, I am a cyclist and love this stuff. The only bad thing is you have to stop taking it at some point! Also, checkout Telmisartan, a very similar compound.
 
Everyone's always recommending not to take clean cause of the heart issues... maybe we shouldn't be so quick to label this as so amazing because of the cancer issues. You know people are going to jump on this without doing any research because of how highly you guys praise it.

Sent from my Nexus S using EliteFitness
 
Everyone's always recommending not to take clean cause of the heart issues... maybe we shouldn't be so quick to label this as so amazing because of the cancer issues. You know people are going to jump on this without doing any research because of how highly you guys praise it.

Sent from my Nexus S using EliteFitness
Go back and read the whole thread and maybe you'll get the whole rundown. Cancer happened with outrageous doses and for VERY long periods of time.... in Rats. Your cell phone is probably giving you cancer as we speak. So is the flouride in your public water... it's a never ending list. Find me an FDA approved drug that can't cause death or horrible side effects, and i'll show you one that does.
 
^^^^ this last sentence speaks volumes, excellent point made!

You are believing what you want to believe. They are not excellent points. Excellent points are based on data, and the data you have is that this drug will never be approved because it is carcinogenic.

I'm not trying to be a fear monger, but on the other hand it is irresponsible for non-experts to post that the data is nothing to worry about.

The methods used to determine the carcinogenicity of this compound are the same methods used to determine it for many other chemicals.

With that said, I know a guy who's been smoking for 55 years and has no cancer, but that doesn't mean I'm going to tell people there is no risk with smoking.
 
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You are believing what you want to believe. They are not excellent points. Excellent points are based on data, and the data you have is that this drug will never be approved because it is carcinogenic.

I'm not trying to be a fear monger, but on the other hand it is irresponsible for non-experts to post that the data is nothing to worry about.

The methods used to determine the carcinogenicity of this compound are the same methods used to determine it for many other chemicals.

With that said, I know a guys who's been smoking for 55 years and has no cancer, but that doesn't mean I'm going to tell people there is no risk with smoking.

No disrespect, the agrument ur having is legitimate, my acknowledgent to his last statement is based on being the husband of a wife that has worked on an oncology floor for 14 years of a prominent hospital. His last sentence regardless of scenario is a valid one.
 
Go back and read the whole thread and maybe you'll get the whole rundown. Cancer happened with outrageous doses and for VERY long periods of time.... in Rats. Your cell phone is probably giving you cancer as we speak. So is the flouride in your public water... it's a never ending list. Find me an FDA approved drug that can't cause death or horrible side effects, and i'll show you one that does.


There's a certain level of fallout that's deemed acceptable for side-effects and risk per benefit of the drug. And in this case, the side effects did not outweigh the benefits of the drug. The case could probably not be made to the FDA surrounding the therapeutic benefits of the drug far outweighing the side effects.

Rats were given high doses and got cancer, yes. Do we know what the threshold is? What minimum dose causes cancer? What the length of exposure needs to be to cause cancer? No. Finding out the answers to these questions would require a separate study.

Either way, Glaxo decided that the benefits were not worth the risk. Was it a financial driven thing? Yes. Were the side effects the cause? Yes. Large companies, Pharma in particular, are concerned with minimizing risk.

Headholio's logic is 100% correct.

Have all these facts and knowledge of how this industry work stop me from jumping on the GW bandwagon? No.
 
You are believing what you want to believe. They are not excellent points. Excellent points are based on data, and the data you have is that this drug will never be approved because it is carcinogenic.

I'm not trying to be a fear monger, but on the other hand it is irresponsible for non-experts to post that the data is nothing to worry about.

The methods used to determine the carcinogenicity of this compound are the same methods used to determine it for many other chemicals.

With that said, I know a guy who's been smoking for 55 years and has no cancer, but that doesn't mean I'm going to tell people there is no risk with smoking.

Gotta agree with Headholio here - studies were at outrageous doses and over a very long period - 100+ weeks at 5,10,15 and 40mg per kilo of body weight.

However - we probably are believing what we want to because GW really is the sh$t and works unbelievably well for our needs. I personally love the stuff but am a little concerned.

Will I cycle it again - yes I will. But only because I'm being a bit of a cowboy and playing the statistics game - it's like surfing. There are men in grey suits in the water, we know they're there and they do occasionally eat is - but f$&k man, I'm gonna paddle out in a good swell!!
 
Gotta agree with Headholio here - studies were at outrageous doses and over a very long period - 100+ weeks at 5,10,15 and 40mg per kilo of body weight.

However - we probably are believing what we want to because GW really is the sh$t and works unbelievably well for our needs. I personally love the stuff but am a little concerned.

Will I cycle it again - yes I will. But only because I'm being a bit of a cowboy and playing the statistics game - it's like surfing. There are men in grey suits in the water, we know they're there and they do occasionally eat is - but f$&k man, I'm gonna paddle out in a good swell!!
I agree with you!
 
its taken orally.. stuff is amazing, atleast it was for me.dose it at 20mg a day..Only problem was it ran out pretty fast for me, im waiting for more to come and i cant wait.

here is the best place to buy it--SS
Too pricey. Already found a source that backs their products up.. SS on the other hand, not looking so good according to quality tests.
 
Too pricey. Already found a source that backs their products up.. SS on the other hand, not looking so good according to quality tests.

if i see this again, i am going to bang my head on a wall.Gw from sarmssearch is 20mg per ml..so its cheaper then a bottle that is 5mg per ml for 50 buck a bottle. do the math please.
 
Gotta agree with Headholio here - studies were at outrageous doses and over a very long period - 100+ weeks at 5,10,15 and 40mg per kilo of body weight.

However - we probably are believing what we want to because GW really is the sh$t and works unbelievably well for our needs. I personally love the stuff but am a little concerned.

Will I cycle it again - yes I will. But only because I'm being a bit of a cowboy and playing the statistics game - it's like surfing. There are men in grey suits in the water, we know they're there and they do occasionally eat is - but f$&k man, I'm gonna paddle out in a good swell!!

i cant argue with this.Bro-ology would say you should be ok.But there is are no guarantees because we arent rats.That being said, i still took my dose of gw today! i got it in the mail yesterday
 
i cant argue with this.Bro-ology would say you should be ok.But there is are no guarantees because we arent rats.That being said, i still took my dose of gw today! i got it in the mail yesterday

GW sucks bro! Send it to me and throw it out. Ill pm you my FedEx account number. Cool?
 
if i see this again, i am going to bang my head on a wall.Gw from sarmssearch is 20mg per ml..so its cheaper then a bottle that is 5mg per ml for 50 buck a bottle. do the math please.

Factor in shipping and "handling" and some other sites are getting close.

I bought mine from SS, but $25 shipping made me want to bang my head against a wall. I do like the product though
 
Factor in shipping and "handling" and some other sites are getting close.

I bought mine from SS, but $25 shipping made me want to bang my head against a wall. I do like the product though

I thought the same! What u need another 25, really? But atm when wanting for pct and backorder was elsewhere, I threw the extra 25 in gladly.
 
I thought the same! What u need another 25, really? But atm when wanting for pct and backorder was elsewhere, I threw the extra 25 in gladly.

sarmsearch gw is still over $30 cheaper then most leading places when you go mg per ml, even with high shipping included.And IMO the higher shipping = faster shipping as well.Choice is yours, anyone who thinks they are gettting a better deal paying less but only getting 5mg of gw per ml, is only fooling themselves honestly lol.
 
sarmsearch gw is still over $30 cheaper then most leading places when you go mg per ml, even with high shipping included.And IMO the higher shipping = faster shipping as well.Choice is yours, anyone who thinks they are gettting a better deal paying less but only getting 5mg of gw per ml, is only fooling themselves honestly lol.

Exactly and as I reviewed quite a bit of threads prior to making a purchase, alot have recommended SS. So like anything of value, you get what u pay for. Shipping took 2 days---Lightning quick!!!
 
sarmsearch gw is still over $30 cheaper then most leading places when you go mg per ml, even with high shipping included.And IMO the higher shipping = faster shipping as well.Choice is yours, anyone who thinks they are gettting a better deal paying less but only getting 5mg of gw per ml, is only fooling themselves honestly lol.

It's still cheaper per mg than any other site for sure. I shopped before I bought lol.

I did buy mine from SS and it took over 7 days... it was a mix-up and well handled by SS etc. And I'm sure this isn't the norm.It's still a great product.
 
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