Very Interesting! Tamoxifern Citrate not Equal to Nolvadex(tamoxifen)

[_Yossarian_]

from the AR board

"15.2 mg of Tamoxifen Citrate equal 10mg of Tamoxifen (nolvadex)

If a research Liquid manufactuer were unaware of this, and they suspend 10mg of Tamoxifen Citrate in 1 ml of solution and claimed a dosage of 10mg of Tamoxifen/ml then it would be underdosed to the tabs.

Of course if they claimed 10mg of Tamoxifen and added 15.2 grams of Tamoxifen citrate then they would be giving the correct dose of then 10mg of Tamox/ml relative to the tabs.

If they say 10mg of Tamoxifen citrate there not lying about the dose, it's jus not as much as the 10mg tabs of nolvadex.

These products are sold as research chemicals with the assumtion that the buyer takes all responsibility for the use of the product, As the buyer we should have some basic knowledge of the chemical research and the properties of the chemicals sold.

NOLVADEX_ (tamoxifen citrate) Tablets, a nonsteroidal antiestrogen, are for oral administration. NOLVADEX Tablets are available as:

10 mg Tablets. Each tablet contains 15.2 mg of tamoxifen citrate which is equivalent to 10 mg of tamoxifen.

20 mg Tablets. Each tablet contains 30.4 mg of tamoxifen citrate which is equivalent to 20 mg of tamoxifen.

http://www.fda.gov/cder/foi/label/1998/17970.pdf"

 

[_Yossarian_]

Assuming most, if not all research chemicals are tamoxifen Citrate, and the research chemicals are the most popular form of anti-e's these days, I would think quite a few people are underdosing, myself included.

 

[Mavy]

Good info bro. Ancillaries are things that are so cheap, that I will ALWAYS use legit pharm stuff. You dont want to take chances with these. Although I here there is a certain lab making UG aromasin tabs now, that does attract me slightly because of the price. He will make a killing off of them.

This could be why you here so many people saying that liqued chems didnt do jack shit for them.

Mavy

 

[lartinos]

20mg's of tamoxifen from pill form has always done the job for me just fine. With liquids you are really just taking a chance because it is pretty much just like using a vet-grade steroid. I did use liquid exem once once I will say.......and it fucking kicked ass.

 

[TheAssholeFomerlyKnownAsDBBT]

from the AR board

"15.2 mg of Tamoxifen Citrate equal 10mg of Tamoxifen (nolvadex)

If a research Liquid manufactuer were unaware of this, and they suspend 10mg of Tamoxifen Citrate in 1 ml of solution and claimed a dosage of 10mg of Tamoxifen/ml then it would be underdosed to the tabs.

Of course if they claimed 10mg of Tamoxifen and added 15.2 grams of Tamoxifen citrate then they would be giving the correct dose of then 10mg of Tamox/ml relative to the tabs.

If they say 10mg of Tamoxifen citrate there not lying about the dose, it's jus not as much as the 10mg tabs of nolvadex.

These products are sold as research chemicals with the assumtion that the buyer takes all responsibility for the use of the product, As the buyer we should have some basic knowledge of the chemical research and the properties of the chemicals sold.

NOLVADEX_ (tamoxifen citrate) Tablets, a nonsteroidal antiestrogen, are for oral administration. NOLVADEX Tablets are available as:

10 mg Tablets. Each tablet contains 15.2 mg of tamoxifen citrate which is equivalent to 10 mg of tamoxifen.

20 mg Tablets. Each tablet contains 30.4 mg of tamoxifen citrate which is equivalent to 20 mg of tamoxifen.

http://www.fda.gov/cder/foi/label/1998/17970.pdf"

Anc. Guys and IBE labs need to post their response to this POST!!!

 

[dr0832]

I saw on the news last night that a study was done that says Tamoxifen causes you an 80% greater chance of having a stroke.

 

[VictorBR]

sorry but this is all bullshit

Nolvadex = tamoxifen citrate

So , 20 mg of tamoxifen citrate is the same SHIT as 20 mg of NOLVADEX .


Victor

 

[chewyxrage]

^^^

 

[[email protected]]

sorry but this is all bullshit

Nolvadex = tamoxifen citrate

So , 20 mg of tamoxifen citrate is the same SHIT as 20 mg of NOLVADEX .


Victor

Thank you Victor. Tamoxifen citrate is just the generic name for Nolvadex.

 

[b1ewsw32]

I saw on the news last night that a study was done that says Tamoxifen causes you an 80% greater chance of having a stroke.

Yeah..I caught that too. Although they did state that the occurances were rare. It doesn't make sense, with the knowledge which we have come to understand regarding the role of tamoxifen for increasing good cholesterol and lowering bad cholesterol.
Perhaps there are othe underlying mechanisms of action which are responsible. Let's have a look....


http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=12624540


Estrogen promotes microvascular pathology in female stroke-prone spontaneously hypertensive rats.

Stier CT Jr, Chander PN, Rosenfeld L, Powers CA.

Department of Pharmacology, New York Medical College, Valhalla 10595, USA. [email protected]

Estrogen produces both beneficial and adverse effects on cardiovascular health via mechanisms that remain unclear. Stroke-prone spontaneously hypertensive rats (SHRSP) maintained on Stroke-Prone Rodent Diet and 1% NaCl drinking water (starting at 8 wk of age) rapidly develop stroke and malignant nephrosclerosis that can be prevented, despite continued hypertension, by drugs targeting angiotensin II and aldosterone actions. This study evaluated estrogen's effects in the SHRSP model. Female SHRSP that were sham operated (SHAM), ovariectomized (OVX) at 4 wk of age, or OVX and treated with estradiol benzoate (E2,30 microg x kg-1 x wk-1) were studied. In a survival protocol, OVX rats lived significantly longer (15.1 +/- 0.3 wk) compared with SHAM (13.6 +/- 0.2 wk) or OVX+E2 rats (12.4 +/- 0.2 wk). In a protocol in which animals were matched for age, at 11.5 wk, terminal systolic blood pressure and urine protein excretion were elevated in SHAM and OVX+E2 rats compared with OVX rats; blood urea nitrogen, renal microvascular and glomerular lesions, and plasma renin concentration were elevated in OVX+E2 relative to SHAM or OVX rats. In a survival protocol using intact female SHRSP, treatment with an antiestrogen (tamoxifen, 7 mg.kg-1.wk-1) prolonged survival by >2 wk compared with controls (P < 0.01). The data indicate that estrogen promotes microangiopathy in the kidney and stroke in saline-drinking SHRSP.

Here's one associating the role of tamoxifen with vascular incidents...

Meta-analysis of vascular and neoplastic events associated with tamoxifen.

Braithwaite RS, Chlebowski RT, Lau J, George S, Hess R, Col NF.

Section of Clinical Systems Modeling, Division of General Internal Medicine, Department of Medicne, University of Pittsburgh, Pittsburgh, PA 15213, USA. [email protected]

OBJECTIVE: Tamoxifen reduces the risk of developing breast cancer but also affects the risks of certain vascular and neoplastic events. Our purpose was to estimate the effects of tamoxifen on potentially life-threatening vascular and neoplastic outcomes. DESIGN: Random effects meta-analysis of published randomized controlled trials. PATIENTS: Participants in all trials in which a treatment arm that included tamoxifen was compared to a similar control arm. Breast cancer risk reduction and treatment trials were included. INTERVENTIONS: Tamoxifen at variable dose and duration. MEASUREMENTS AND MAIN RESULTS: Thirty-two trials (52,929 patients) reported one or more outcomes of interest. Tamoxifen was associated with significantly increased risks of endometrial cancer (relative risk [RR] 2.70; 95% CI, 1.94 to 3.75), gastrointestinal cancers (RR 1.31; 95% CI, 1.01 to 1.69), strokes (RR 1.49; 95% CI, 1.16 to 1.90), and pulmonary emboli (RR 1.88; 95% CI, 1.77 to 3.01). Tamoxifen had no effect on secondary malignancies other than endometrial and gastrointestinal cancers (RR 0.96; 95% CI, 0.81 to 1.13). In contrast, tamoxifen significantly decreased myocardial infarction deaths (RR 0.62; 95% CI, 0.41 to 0.93) and was associated with a statistically insignificant decrease in myocardial infarction incidence (RR 0.90; 95% CI, 0.66 to 1.23). Postmenopausal women had greater risk increases for neoplastic outcomes. CONCLUSIONS: This meta-analysis of randomized trials found tamoxifen use to be significantly associated with several neoplastic and vascular outcomes. Consideration of tamoxifen use requires balance of potential benefits and risks.


BTW...Victor keep in mind that by law generics only have to be manufactured at 85% of the brand name. So it would come to no surprise that most generics would fall short of the 99.99%purity of a nolvadex tab by zeneca.

B32

 

[NaturalOnlyAtBirth]

Did you not see these 2 lines of the post??

10 mg Tablets. Each tablet contains 15.2 mg of tamoxifen citrate which is equivalent to 10 mg of tamoxifen.

20 mg Tablets. Each tablet contains 30.4 mg of tamoxifen citrate which is equivalent to 20 mg of tamoxifen.


It states that 20mg of the namebrand NOLVADEX is = to 30.4mg of tamoxifen citrate. READ! I went to FDA.gov myself to confirm, its the same there. Just take a bigger dose if your taking generic .

 

[DIVISION]

Nolvadex = tamoxifen citrate

100% correct.

Because some UGlabs are underdosing their tabs/liquids doesn't mean that the chemical is not the same thing.

Nolvadex = Tamoxifen Citrate

That's real.


DIV

 

[VictorBR]

BTW...Victor keep in mind that by law generics only have to be manufactured at 85% of the brand name. So it would come to no surprise that most generics would fall short of the 99.99%purity of a nolvadex tab by zeneca.B32

>>>> I see your point . Anyway , in this case the GENERIC TAMOXIFEN CITRATE would be UNDERDOSED .

Well , nolvadex contains 20 mg of tamoxifen citrate and the generic tamoxifen citrate would contain at LEAST 17 mg of this substance ( 15 % less ) .

This is the worst case that could happen .

But now , can someone explain to me HOW the FUCK a 10 mg tab can CONTAIN 15 mg OF ANYTHING ??????!?!?!?!!?!?

10 mg tabs contains MAX 10 mg of anything , be it tamoxifen citrate or pee or poo poo . I think it is physically impossible for a 10 mg tab to contain more than 10 mg of the substance .

Unless of course , they say that the tab is 10 mg of nolvadex and the tab is actually 15 mg . But I don't think this is the case . Why they would do that ? If the nolvadex tabs have 15 mg of tamoxifen citrate why they would sell it saying that it has 10 mg ? They would label it with 15 mg ..... It makes no sense .


Victor

 

[hard life]

Thanks guys now you got me worried about the generic nolv I just got! Good to know though, but hey 17mg out of 20mg is still not bad for me.

 

[fugetaboutit]

>>>> I see your point . Anyway , in this case the GENERIC TAMOXIFEN CITRATE would be UNDERDOSED .

Well , nolvadex contains 20 mg of tamoxifen citrate and the generic tamoxifen citrate would contain at LEAST 17 mg of this substance ( 15 % less ) .

This is the worst case that could happen .

But now , can someone explain to me HOW the FUCK a 10 mg tab can CONTAIN 15 mg OF ANYTHING ??????!?!?!?!!?!?

10 mg tabs contains MAX 10 mg of anything , be it tamoxifen citrate or pee or poo poo . I think it is physically impossible for a 10 mg tab to contain more than 10 mg of the substance .

Unless of course , they say that the tab is 10 mg of nolvadex and the tab is actually 15 mg . But I don't think this is the case . Why they would do that ? If the nolvadex tabs have 15 mg of tamoxifen citrate why they would sell it saying that it has 10 mg ? They would label it with 15 mg ..... It makes no sense .


Victor

Good point meu amigo. Essas otras respostas sao completamente idiotas!

 

[newshipping]

Yossarian is correct.

A fully dosed 20mg tamoxifen tab contains 30.4 mg of tamoxifen citrate ( which is equivalent to 20 mg of tamoxifen ).

This same issue exists with most tabs that contain a salt of the active ingredient some examples of which are Viagra and Cialis.

S.B.C

 

[Mavy]

Yossarian is correct.

A fully dosed 20mg tamoxifen tab contains 30.4 mg of tamoxifen citrate ( which is equivalent to 20 mg of tamoxifen ).

This same issue exists with most tabs that contain a salt of the active ingredient some examples of which are Viagra and Cialis.

S.B.C

If anyone would know .. it would be this man right here! Good to see you posting ... without someone hijacking your account. lol.

I can understand this, because if you have ever bought certain powders before, and you see how little it actually looks like for how many grams you have, you can realize how little of active ingredient there is in a tab/cap and how much is filler. For many drugs, a little goes a long way.

 

[newshipping]

A real pharmaceutical company will use a typical tab api to filler/binder ratio of 1:8, eg a 50mg tab would have a total weight of 400mg.

Obviously for smuggling purposes the lighter and smaller a tab is the better which is why some UG AS tabs use ratios as low as 1:3 eg a 25mg tab would have a total weight of just 75 mg.

S.B.C

I can understand this, because if you have ever bought certain powders before, and you see how little it actually looks like for how many grams you have, you can realize how little of active ingredient there is in a tab/cap and how much is filler. For many drugs, a little goes a long way.

 

[lartinos]

The price difference has been quite drastic from what i've seen, with nolva being alot more expensive then the generic. I swear by all the generics I have tried, and i've tried a bunch of them .

 

[ceo]

this is all in the PDR.