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UPDATE to 1.5 years and Still Shudown

Jenetic

Don Anabolico
Platinum
UPDATE to 1.5 years and Still Shutdown

Up until a month ago. I have been shut down for over 1.5 years. Some of you have read the thread and I thank everyone who offered their time, opinions and support.

The bottom line if you want to resolve a serious medical problem like this, Secondary Aquired Hypogonadatropic Hypogonadism, is to get a qualified doctor and have your blood work done. There are many factors involved which many of us are more than likely unaware of. Most of you that have spoken to me or read my posts will probably say that I have a decent ammount of knowledge in regards to the game and now are probably wondering how did something like this happen. Simple, ABUSE and a ignorant attitude that more than likely it won't happen to me. Im sure you can all see that I am much more humble now. LOL

After finding the right Endocrinologist, the key is to present the case to him in the right way. Don't just come clean and say hey I juiced, I'm all fucked up and I need help. It may seem like the right idea but some take offense to it for their own reasons such as you are just a drug abuser. Try something like, I am or was an athlete. The team or coached preassured me into doing this. I had no idea about the side effects. They told me it was totally safe. Now I am having all these problems and do not know what to do. This will demonstrate that you didn't try to take matters into your own hands to begin with. You have admit you made a stupid mistake and recognize you need professional help. Also, let him know you are not looking for a quick answer but his or her's proffesional long term, if necessary, guidance and assistance.

I went through 4 different doctors until the one I have now. Finally, after a month, I am almost back to normal which includes an improvement in overall mood, strength and energy and most importantly Libido. One personal recomendation is to stay away from the female doctors. I delt with 2 that were both non sympathetic to the condition nor did they understand it from a male point of view.

A major problem I personally noticed was that I never had any initial values to compare my current ones to. Therefore, after blood tests, my results usually showed borderline or low normal values. Many of the doctors considered them to be normal or felt that, although low, things should return to normal on their own. What many of them still don't realize is that although the numbers are in technically normal ranges, it does not mean that the individual is functioning properly or feeling well due to the fact that conditions like this must be reviewed and delt with on an individual basis.

The treatment I am on is quite different than is what is recomended here so I never bothered to post it until now. It is missing many of the common components recomended here, has astoundingly high dosages and has an ingredient that nobody here has happened to mention, including docotors.

5,0000 iu's HCG 3 times per week
150 iu's HMG (FSH/LH) 3 times per week

Like I said, it has been a month now and I am almost back to normal. We are now in the process of tapering down the dosages and monitoring for consistent hormone levels next. Obviously my condition is extreme. My program totally goes against most recomendations on this board but it is working. One of the most common things that people develop on high doses of HCG is Gynecomastia. I have zero symptoms.

Take advantage of what the board has to offer. A community of people with various experiences, knowledge and a place to share information. As long as you keep your cycles to reasonable dosages and time frames, this board has the majority of the information you need to resolve your questions and concerns. Be ready to accept the consequences for not thoroughly educating and preparing yourself. There are many brilliant, knowlegable and supportive people here but you need to get the opinion of an EXPERIENCED professional when dealing with a serious medical condition. Especially, when doing a highly unrecommended long term cycle and ending up in an extreme condition like myself. LOL

Once again, Thanks to all those who participated in previous thread and I hope the people reading this one have learned something from it.

Jenetic
 
Last edited:
"You must spread some Karma around before giving it to Jenetic again."

I'm happy you're doing better. You said you are feeling much better, are blood tests being made after at least 2 weeks after all these HCG shots? I guess waiting about 2-3 weeks after these shots will yield more accurate 'natural' levels.

I must admit I've never ever came across on dosages such has 5,0000 iu's HCG 3 times per week. You mean 10ml (5000iu/ml X 10) shot 3 times a week?!? Holly shit, how? Also, it's amazing not to have gyno at these dosages.

The 150 iu's HMG (FSH/LH) 3 times per week is also on interest, I wonder how I never came across it.
 
How do you know when your natural levels are not where they should be? I know the obvious answer is bloodwork, which I had done after my last cycle and the doctor just reported that my liver values were fine and my red blood cell count was high (typical of steriod exposure). But what symptoms would I have if my natural test levels were abnormally low? And at what point in time do you make the decision that they will not adjust on their own and that professional medical attention may be necessary?
 
bigbair said:
How do you know when your natural levels are not where they should be? I know the obvious answer is bloodwork, which I had done after my last cycle and the doctor just reported that my liver values were fine and my red blood cell count was high (typical of steriod exposure). But what symptoms would I have if my natural test levels were abnormally low? And at what point in time do you make the decision that they will not adjust on their own and that professional medical attention may be necessary?

I would think when your women leaves you because your not giving it to her anymore, Because you cant or dont want to. Because you cant keep gains made. You feel like crap no energy theres lots of reasons Bro.
 
Do you plan to go back on when you reach normal levels? If so how are you going to handle PCT in the future?
 
I would be curious to hear whether your libido is intact AFTER you've gone off the hcg. Hell, 5000x3 could give a dead man wood.

Very best of luck. K for you.
 
I'd like to know what you ran, for how long, and for how long you were OFF completely before a month ago, when you started all this. Also, what did you try for your PCT?
 
human menopausal gonadotropin. here s a pubmed study:


Men with the complete form of isolated hypogonadotropic hypogonadism (initial mean testes volume less than 4 mL) require 2 or more yr of exogenous gonadotropin therapy combining hCG and human menopausal gonadotropin (hMG) to achieve maximal, but subnormal, testis size and sperm output. To test whether pulsatile GnRH therapy, which more closely mimics normal hormonal stimulation, would accelerate or further augment testicular growth, hasten the onset of sperm production, and/or increase sperm output more than occurs during conventional exogenous gonadotropin therapy, we administered either hCG/hMG or GnRH from the inception of therapy to 2 comparable groups of men with complete IHH (initial testicular volume, less than 4 mL) and compared their testicular responses during the first 2 hr of therapy. Five men were treated with pulsatile GnRH in doses of 143-714 ng/kg every 2 h, sc, while 11 other men received hCG (2000 IU) and hMG (75 IU FSH and 75 IU LH) im 3 times/week. In the GnRH-treated men, the mean plasma total and free testosterone levels during therapy rose to within the normal range, but were significantly lower (P less than 0.01 and P less than 0.02, respectively) than those in the hCG/hMG-treated men. The mean plasma estradiol concentrations during therapy were within the high normal range and were similar in the two groups. The mean plasma FSH levels achieved in the GnRH-treated men were significantly (P less than 0.01) and 1.3- to 3.2-fold higher than those in the hCG/hMG-treated men. The mean testicular size achieved in the GnRH-treated men was not significantly different from that in the hCG/hMG-treated men (P = 0.08); the mean testicular volumes after 2 yr were 4.8- and 4.3-fold the pretreatment values in the GnRH and hCG/hMG groups, respectively. After 12 months of therapy, sperm production had occurred in one man in the GnRH group and in no subject in the hCG/hMG group. After 24 months, two men in the GnRH group and eight men in the hCG/hMG group produced sperm. Thus, 40% of the GnRH-treated men and 80% of the hCG/hMG-treated men (P = NS) produced sperm after 2 yr of therapy. The sperm concentrations in all men were below 5 million/mL and were comparable in the two groups (P = NS). These results suggest that pulsatile sc GnRH therapy for the first 2 yr does not accelerate or enhance testicular growth, hasten the onset of sperm production, or increase sperm output significantly compared to hCG/hMG.
 
CYPHON said:
human menopausal gonadotropin. here s a pubmed study:


Men with the complete form of isolated hypogonadotropic hypogonadism (initial mean testes volume less than 4 mL) require 2 or more yr of exogenous gonadotropin therapy combining hCG and human menopausal gonadotropin (hMG) to achieve maximal, but subnormal, testis size and sperm output. To test whether pulsatile GnRH therapy, which more closely mimics normal hormonal stimulation, would accelerate or further augment testicular growth, hasten the onset of sperm production, and/or increase sperm output more than occurs during conventional exogenous gonadotropin therapy, we administered either hCG/hMG or GnRH from the inception of therapy to 2 comparable groups of men with complete IHH (initial testicular volume, less than 4 mL) and compared their testicular responses during the first 2 hr of therapy. Five men were treated with pulsatile GnRH in doses of 143-714 ng/kg every 2 h, sc, while 11 other men received hCG (2000 IU) and hMG (75 IU FSH and 75 IU LH) im 3 times/week. In the GnRH-treated men, the mean plasma total and free testosterone levels during therapy rose to within the normal range, but were significantly lower (P less than 0.01 and P less than 0.02, respectively) than those in the hCG/hMG-treated men. The mean plasma estradiol concentrations during therapy were within the high normal range and were similar in the two groups. The mean plasma FSH levels achieved in the GnRH-treated men were significantly (P less than 0.01) and 1.3- to 3.2-fold higher than those in the hCG/hMG-treated men. The mean testicular size achieved in the GnRH-treated men was not significantly different from that in the hCG/hMG-treated men (P = 0.08); the mean testicular volumes after 2 yr were 4.8- and 4.3-fold the pretreatment values in the GnRH and hCG/hMG groups, respectively. After 12 months of therapy, sperm production had occurred in one man in the GnRH group and in no subject in the hCG/hMG group. After 24 months, two men in the GnRH group and eight men in the hCG/hMG group produced sperm. Thus, 40% of the GnRH-treated men and 80% of the hCG/hMG-treated men (P = NS) produced sperm after 2 yr of therapy. The sperm concentrations in all men were below 5 million/mL and were comparable in the two groups (P = NS). These results suggest that pulsatile sc GnRH therapy for the first 2 yr does not accelerate or enhance testicular growth, hasten the onset of sperm production, or increase sperm output significantly compared to hCG/hMG.

Good post Cyphon.

Still, I really want to know what Jenetic took that landed him in this state.
 
Guvna said:
good luck to you, thanks for the post.


and whats HMG? shit, I cant believe I have never heard of it.

We use HCG mimicks LH which stimulates the testes to produce testerone. I believe that HCG also has some FSH properties. FSH stimulates sperm production. HMG mimicks FSH.

Post cycle you are mostly worried about bring test levels back up and that is what HCG does. I think in this case, the doctor is trying to restore sperm production also. I don't think HMG does much for testosterone, but could be wrong.

I would also suspect that HMG is not as available and possibly more costly.
 
Nathan said:
I'd like to know what you ran, for how long, and for how long you were OFF completely before a month ago, when you started all this. Also, what did you try for your PCT?

For everyone who is not aware of my dosages, I will do my best to recall the madness. Keep in mind, I was on for about a year. Probably a little longer. Also, once I discontinued that cycle, I have been clean ever since.

50-75 mgs DBOL ED
1250 mgs Sustanon
1000 mgs EQ

100 mgs Propionate ED
600 mgs EQ
75 mgs Trenbolone ED

100 mgs Propionate ED
500 mgs Primo per week
75 mgs Trenbolone EOD
60 mgs Anavar ED
25 mcg - 100 mcg T3 ED
100 mcg - 220 mcg T3 ED

50 mgs Anadrol ED
100 mgs Suspenstion ED
100 mgs Winstrol ED

1000 mgs Test per week
9 iu's GH ED
10 iu's Humulin R ED
10 iu's Humalog ED
50 mcg T3 ED

Then I slowly tapered off for about 1 month after with Propionate and GH. It was something like that. I can't completely recall at this point I may be leaving somethings out but I used Aromasin, Arimidex, Finasteride and other acilliaries at different points throughout the year.

The PCT that I attempted was:

5000 iu's HCG 3x per week for the first week
2500 iu's HCG 3x per week for the second week
1500 iu's HCG 3x per week for the third week
500 iu's HCG 3x per week for the fourth week
150 mgs Clomid ED for the fifth week
100 mgs Clomid ED for the sixth week
50 mgs Clomid ED for the seventh week
40 mgs ED from first week to the fourth week
20 mgs ED from fifth week to the seventh week
 
Nathan said:
Oh yeah, do you know how your fertility has been affected by all this?

I don't know exactly. We haven't done a semen analysis yet. What I can tell you is that my sperm volume was low up till I started treatment with this doctor. Now the sperm volume has increased dramatically and is pretty much normal now.
 
Jenetic said:
For everyone who is not aware of my dosages, I will do my best to recall the madness. Keep in mind, I was on for about a year. Probably a little longer. Also, once I discontinued that cycle, I have been clean ever since.

50-75 mgs DBOL ED
1250 mgs Sustanon
1000 mgs EQ

100 mgs Propionate ED
600 mgs EQ
75 mgs Trenbolone ED

100 mgs Propionate ED
500 mgs Primo per week
75 mgs Trenbolone EOD
60 mgs Anavar ED
25 mcg - 100 mcg T3 ED
100 mcg - 220 mcg T3 ED

50 mgs Anadrol ED
100 mgs Suspenstion ED
100 mgs Winstrol ED

1000 mgs Test per week
9 iu's GH ED
10 iu's Humulin R ED
10 iu's Humalog ED
50 mcg T3 ED

Then I slowly tapered off for about 1 month after with Propionate and GH. It was something like that. I can't completely recall at this point I may be leaving somethings out but I used Aromasin, Arimidex, Finasteride and other acilliaries at different points throughout the year.

The PCT that I attempted was:

5000 iu's HCG 3x per week for the first week
2500 iu's HCG 3x per week for the second week
1500 iu's HCG 3x per week for the third week
500 iu's HCG 3x per week for the fourth week
150 mgs Clomid ED for the fifth week
100 mgs Clomid ED for the sixth week
50 mgs Clomid ED for the seventh week
40 mgs ED from first week to the fourth week
20 mgs ED from fifth week to the seventh week

I've been in a situation very similar to yours, as you have evidenced by some of my posts in the past.
Both my urologist and andrologist were very helpful in returning my hormonal paraters to homeostatis.
Hcg and HMG is given in conjunction to many who have prolonged use/abuse of AAS. The usual protocol is to titrate the HCG up to 5000i.u. 3x weekly if needed. This is a common protocol for Hypogonadism(after sexual maturity) ie.4000-5000 iu's 3x weekly for 6-8 wks. with a rest period of 2-3 weeks between courses of therapy. Then HmG may have to be added if there is not adequate response with HCG alone.
Did your doctor recomend or did you self administer aromasin during your gonadotropic stint? Lack of gynocomastia is amazing at that dose.
I hope your recovery goes well and that you can sustain decent levels of free testosterone after anti-e's or serms are discontinued.

Best of Luck...B32
 
"You have given out too much Karma in the last 24 hours, try again later."

I will make sure to hit everyone who participated in this discussion with K to show my appreciation.

Thanks
 
Bros I am on Hrt now but would like to know more about fertility/sperm production recovery, this was an awesome insight, anymore info would be great K to ya guys
 
Good luck man. Include in your PCT going to strip clubs
:p
 
the second drug is just another which is used to mimic natural hormones and reregulate the hpta. i know you guys are getting hard ons over it but please leave it where it is, dont use it, or risk becoming a test dummie for new therapies to fix up your uniquely fucked up hpta.

i have heard of hcg used at that dose. not at all uncommon. arguably they could use less with comparable results, but so long as youre not getting any sides and are under specialist care, its no problem.

thanks for posting this thread, it would be an excellent idea for a mad or yourself to combine both threads and make a sticky about them, because really, people are becoming more and more blase about horrendously overdosed and lengthy cycles. I know several people who have been on for more than a year, and they are in complete denial about what is likely to occur when they come off. if ever they do. i get the feeling that when they come off, theyll promptly go back on to avert what is happening to them

excellent to see youre recovering.

cheers :)
 
Jenetic thanks for sharing this incredible helpful and full of information thread, and again wish you very fast complete recovery.

I would like to know, for the past year and half that you claimed to be shut down,
what where your LH and TEST blood test readings? Also, being supressed for such a long period of time, how did it effect your physique? Did you loose all muscle and all strength? I mean, I can't imagine being ultra supressed for such a long period of time without loosing every bit of muscle tissue and strength ?

Also, during the year when you were non-stop juicing, did you use HCG from time to time and at what dosages to possibly help with PCT later on?

And last question which is quite relevant, what is your age? Recovery abilities are quite age depandant
 
junk said:
Jenetic thanks for sharing this incredible helpful and full of information thread, and again wish you very fast complete recovery.

I would like to know, for the past year and half that you claimed to be shut down,
what where your LH and TEST blood test readings? Also, being supressed for such a long period of time, how did it effect your physique? Did you loose all muscle and all strength? I mean, I can't imagine being ultra supressed for such a long period of time without loosing every bit of muscle tissue and strength ?

Also, during the year when you were non-stop juicing, did you use HCG from time to time and at what dosages to possibly help with PCT later on?

And last question which is quite relevant, what is your age? Recovery abilities are quite age depandant


Bump
 
junk said:
Jenetic thanks for sharing this incredible helpful and full of information thread, and again wish you very fast complete recovery.

I would like to know, for the past year and half that you claimed to be shut down,
what where your LH and TEST blood test readings? Also, being supressed for such a long period of time, how did it effect your physique? Did you loose all muscle and all strength? I mean, I can't imagine being ultra supressed for such a long period of time without loosing every bit of muscle tissue and strength ?

Also, during the year when you were non-stop juicing, did you use HCG from time to time and at what dosages to possibly help with PCT later on?

And last question which is quite relevant, what is your age? Recovery abilities are quite age depandant

Junk,

I don't have any of my old test readings on hand. I do have a current one which was performed prior to my current treatment. For some reason this one is slightly different than my previous tests with the other doctors because it only has one testosterone reading.

Testosterone: 7.85
FSH: 3.49
LH: 11.30
E2: 44.90
Prolactin: 6.09
TSH: 2.39
IGF-1: 68.2
PSA: 0.510
AST: 24
ALT: 25
Total Cholesterol: 147
Triglyceride: 92
HDL: 57.8

If you take a look, you will notice that my values pretty much fall within normal ranges except for my IGF-1 Levels. One thing I found interesting is that my AST, ALT, Cholesterol, Triglyceride and HDL values were all normal. By no means should anyone use these figures to justify that using AAS will not result in liver damage. It is interesting that there was no damage in my particular case.

The most recent blood test prior to this one was six months ago. I don't remember specific numbers but I do know that they were significantly different and closer to borderline or low normal ranges. In conclusion, this is why I made the statement that normal values do not necessarily mean that the INDIVIDUAL is functioning properly. It was my doctor that actually pointed that out to me and asked if I had any initial values where we could compare them to.

My libido definitely has made consistent progress even before treatment. Prior to treatment, I was able to obtain an erection but was not able to hold it for long and in the months before that, I literally could not get a hard on even with Cialis. One thing that I do want to point out is that my balls were still about half the size they used to be in correspondece with the values that I listed above.

To answer your question about physical strength and muscle loss, let me just say this "Worst Possible Scenario." Use your imagination. LOL

I did not use HCG throghout that heavy cycle. It would be interesting to know how much I would have benefited from it but it's too late now.

The answer to the last question is 25.

Hope that helps shine some light on things.

Jenetic
 
Last edited:
Carth said:
Jenetic...why didn't the doctor just prescribe you Testosterone? Like in shots or in androgel form?

One thing you need to keep in mind is that our goal was to return my body to Homeostasis. HRT such as testosterone would definitely show an improvement in my overall sense of well being, but it would also further surpress my HTPA (also keep in mind my decreased sperm volume) and reduce any chances of every returning my body to Homeostasis. Basically, it would do more damage than good under the circumstances.
 
Thanks Jenetic take care.

You must spread some Karma around before giving it to Jenetic again
 
Your original post was misleading I think and please correct me if you disagree with me at all. You said you had been "shut down" for over 1.5 years until last month, which from the sounds of things is not really true. From the way you are describing things everything was technically working, only it was operating at a sub-par level in your case. You were producing sperm and testosterone, just not at the same output as you used to. You used more hormone therapy to manipulate your LH and FSH levels a that point and it finished off the job for you. Had you maybe taken a small break after your first PCT and then done it all over again, you very might have not had such low test levels for all that 1.5 years. Does any of that sound accurate to you or am I totally wrong? That all makes sense though I think. We all know you're likely to crash after a cycle if you forego the PCT alltogether. So, in the case of larger cycles like the one you did, you need a more aggressive and lengthier PCT treatment. Expect a good 6 months + (depending on duration of longer cycles) of recovery time and be aggressive with the PCT in that time. Everyone probably says time on = time off for a reason.
 
Nathan said:
Your original post was misleading I think and please correct me if you disagree with me at all. You said you had been "shut down" for over 1.5 years until last month, which from the sounds of things is not really true. From the way you are describing things everything was technically working, only it was operating at a sub-par level in your case. You were producing sperm and testosterone, just not at the same output as you used to. You used more hormone therapy to manipulate your LH and FSH levels a that point and it finished off the job for you. Had you maybe taken a small break after your first PCT and then done it all over again, you very might have not had such low test levels for all that 1.5 years. Does any of that sound accurate to you or am I totally wrong? That all makes sense though I think. We all know you're likely to crash after a cycle if you forego the PCT alltogether. So, in the case of larger cycles like the one you did, you need a more aggressive and lengthier PCT treatment. Expect a good 6 months + (depending on duration of longer cycles) of recovery time and be aggressive with the PCT in that time. Everyone probably says time on = time off for a reason.

Nathan,

What is your definition of "shut down"? When I say "shut down" I am referring to being in a clinical state of Hypogonadatropic Hypogonadism. Doesn't that qualify? I apologize if that sounded misleading. The blood test that I had done during the time of the original thread was approximately 1.5 years after the cessation of cycle. Those test results were nowhere near the above posted statistics. Unfortunately, I don't have them on hand but rest assured, they were not pretty. Also, I did attempt Gondatropin therapy again sometime during the time period I was reffering to (about six months after the first PCT). Based on blood tests, it displayed an improvement but the effects and results rapidly diminished after discontinuation which was proven by further test reports. This was probably due to the fact that my dosages and overall time of usage were insufficient. For a brief period of time, everything actually seemed to worsen after the second attempt.
 
Jenetic said:
I did attempt Gondatropin therapy again sometime during the time period I was reffering to (about six months after the first PCT). Based on blood tests, it displayed an improvement but the effects and results rapidly diminished after discontinuation which was proven by further test reports. This was probably due to the fact that my dosages and overall time of usage were insufficient. For a brief period of time, everything actually seemed to worsen after the second attempt.

Cool. That helps a lot more. All I was trying to ask was whether or not you think you could have gotten your levels back to "normal" a lot sooner had you done a few things differently? From your story, I was under the impression that your levels were coming back, bit by bit, but that you did PCT stuff off and on only in that time. I was just trying to learn from your mistakes is all, and I really appreciate you taking the time to answer all the questions since it could just as easily happen to any one of us.
 
Nathan said:
Cool. That helps a lot more. All I was trying to ask was whether or not you think you could have gotten your levels back to "normal" a lot sooner had you done a few things differently? From your story, I was under the impression that your levels were coming back, bit by bit, but that you did PCT stuff off and on only in that time. I was just trying to learn from your mistakes is all, and I really appreciate you taking the time to answer all the questions since it could just as easily happen to any one of us.

Thanks Nathan. I completely understand where you are comming from. I appreciate your concern and I am glad you asked the question as it does help clearify the topic at hand. Looking at my previous post, I can see where it possibly came off as defensive. I assure you that was not the intention. :) Never hesitate to ask me questions. I am here to do my best to share the details of my condition as well as to help educate everyone so that they won't make the same mistake and to give them the best possible advice I can for recovery in a situation like this based upon my experience.

Jenetic
 
Jenetic said:
Thanks Nathan. I completely understand where you are comming from. I appreciate your concern and I am glad you asked the question as it does help clearify the topic at hand. Looking at my previous post, I can see where it possibly came off as defensive. I assure you that was not the intention. :) Never hesitate to ask me questions. I am here to do my best to share the details of my condition as well as to help educate everyone so that they won't make the same mistake and to give them the best possible advice I can for recovery in a situation like this based upon my experience.

Jenetic

Cool. Seriously though, do you think you could have gotten your levels back to normal any sooner had you done things differently? What would you have done differently? :)
 
prose.htm
 
Nathan said:
Cool. Seriously though, do you think you could have gotten your levels back to normal any sooner had you done things differently? What would you have done differently? :)

Most definietely. I should have been just as meticulous about aquiring an experienced doctor as I was with my AAS. I am more than confident that this situation could have been resolved within 6 months under the proper care and supervision of an experienced proffessional. Regular blood testing should have been common practice as well. Overall, minimal negative impact on net physiological strength and muscle gains would have resulted and my overall quality of life would not have been as dramatically affected.
 
Jenetic said:
Most definietely. I should have been just as meticulous about aquiring an experienced doctor as I was with my AAS. I am more than confident that this situation could have been resolved within 6 months under the proper care and supervision of an experienced proffessional. Regular blood testing should have been common practice as well. Overall, minimal negative impact on net physiological strength and muscle gains would have resulted and my overall quality of life would not have been as dramatically affected.

You basically just wrote exactly what I was trying to say. I'm really glad you said it though because I'll be taking my PCT therapies more seriously from now on and am going to get some hcg to use mid-way through my next lengthy cycle. Thanks bro.
 
Great to hear that a doc is helping you. I wish I was so lucky.

quote:
Testosterone: 7.85
FSH: 3.49
LH: 11.30

I think your FSH and LH are in the normal range, so you don't have a problem with your pituitary/hypothalamus, only with the balls i.e. PRIMARY hypogonadism. Then I do not understand why they would add LH/FSH to the HCG.... That seems to me counterproductive
 
Sigmund Roid said:
I do not understand why they would add LH/FSH to the HCG.... That seems to me counterproductive

I have been analyzing various factors and my brain is about to explode with the ammount of information I have been trying to process. Finally, it is all starting to make some sense, to some extent. This is just a theory based on some studies I have read and should not be taken too seriously. Some of the stuidies were perfomed on rats which could severely throw this theory off because the results of the studies may be species dependant.

It seems that FSH may enhance the responsiveness of Leydig cells to LH. One study showed that FSH treatment induced Leydig cell hyperplasia, increased the number of testicular LH receptors, and increased the steroidogenic response of Leydig cells to LH. FSH further enhanced the steroidogenic capacity of Leydig cells and induced a significant increase in the number of hCG receptors which would increase the the sensitivity and effectiveness of HCG. If this is all "true", it would make sense to use a combination of HCG and HMG (FSH/LH) to initiate and maintain restoration of normal Testosterone secretion and achieve spermatogenesis in people with severe Hypogonadatropic Hypogonadism.
 
Jenetic, that makes sense

I wonder what happens if after total restoration of hormone levels the subject is taken off those substances. In my case I react very well on low dosages of clomid (secondary hypo), but as soon as I finish clomid therapy, my levels drop back to the very low range again.
 
Generic MALE said:
So what does your doctor think of HGH for the low IGF-1 levels?

He doesn't feel it's a big deal. He say's the IGF-1 levels will also increase during my treatment. Regardless, he did give me the option of HGH. Currently taking 1 IU ED Norditropin.
 
Jenetic said:
He doesn't feel it's a big deal. He say's the IGF-1 levels will also increase during my treatment. Regardless, he did give me the option of HGH. Currently taking 1 IU ED Norditropin.

Are you gaining size back now?
 
Nathan said:
Are you gaining size back now?

The treatment has been going fantastic. My strength and endurance is significantly increasing every week. It's funny because it looks like I am making gains that a cycle would give me. No supplements involved including protein shakes. Only solid foods. I finally have what it takes again to sustain a full blown workout.
 
Jenetic I was wondering if you had already or might consider running a-dex by itself in order to "shock" your body into producing more testosterone . I have read at least 3 different studies here on the board that indictate user's in the study have had increases of up to 53% in T levels...
 
Jenetic said:
I have been analyzing various factors and my brain is about to explode with the ammount of information I have been trying to process. Finally, it is all starting to make some sense, to some extent. This is just a theory based on some studies I have read and should not be taken too seriously. Some of the stuidies were perfomed on rats which could severely throw this theory off because the results of the studies may be species dependant.

It seems that FSH may enhance the responsiveness of Leydig cells to LH. One study showed that FSH treatment induced Leydig cell hyperplasia, increased the number of testicular LH receptors, and increased the steroidogenic response of Leydig cells to LH. FSH further enhanced the steroidogenic capacity of Leydig cells and induced a significant increase in the number of hCG receptors which would increase the the sensitivity and effectiveness of HCG. If this is all "true", it would make sense to use a combination of HCG and HMG (FSH/LH) to initiate and maintain restoration of normal Testosterone secretion and achieve spermatogenesis in people

I found this study that concluded that FSH + LH did not provide anything above LH on its own. Here is the summary paragraphs:

-----

In the present study, the increase in mean plasma T levels induced by rhLH was not enhanced by the concomitant administration of rhFSH, despite the effective stimulation of Sertoli cell function, attested by the increase in plasma inhibin B. The same result was observed with a greater increase in plasma T levels after hCG and hCG plus rhFSH administration. These results are in agreement with recent studies performed in primates (30). Indeed, in juvenile rhesus monkeys receiving a pulsatile iv infusion of GnRH, the concomitant infusion of rhFSH did not affect either the mean plasma levels of T or the amplitude of pulsatile testicular T secretion. Therefore, in man as in primates, the physiological relevance of a role of FSH in LH-induced testicular steroidogenesis seems questionable.

In conclusion, complete acquired HH and the use of rhLH and rhFSH enable the functions of Leydig and Sertoli cells to be studied selectively. Apart from peripheral aromatization of testicular T, the increase of plasma E2 induced by rhLH and the absence of an effect of rhFSH is consistent with the view that Leydig cells are the major site of testicular E2 production in man. The secretion of inhibin B, increased by rhFSH and not by rhLH, confirms that Sertoli cells are the main source of inhibin B production. Finally, the increase in plasma T induced by rhLH or hCG was not enhanced by rhFSH. These results suggest that the stimulatory effect of FSH on Leydig cell steroidogenesis by a Sertoli cell paracrine factor does not seem to play a major physiological role in man.
 
Mr. Black said:
Jenetic I was wondering if you had already or might consider running a-dex by itself in order to "shock" your body into producing more testosterone . I have read at least 3 different studies here on the board that indictate user's in the study have had increases of up to 53% in T levels...

Mr.B,

I am fully aware of what you are saying. Take a further look at those studies. The first thing you will notice is the decrease it causes in IGF-1. Also, there are studies that show that it tampers with your lipid profile.

Aromasin would be that way to go in this situation. I am acutally considering it right now. No impact to IGF-1 and lipid profile in addition to the increase in testosterone. Obviously the increase will be short lived and will subside after discontiuation, but the benefits might be worth it for a temporary period of time. This may prove to be a new PCT option to be used in conjunction to HCG. Something to think about.

Jenetic
 
Jenetic said:
Mr.B,
Obviously the increase will be short lived and will subside after discontiuation, but the benefits might be worth it for a temporary period of time.Jenetic

Unfortunately in the studies they did no mention the long term status of the testosterone boost. It's obvious that any test level above and beyond one's genetic make-up simply will not hold. However, if your current T is indeed below those of your pre-AAS days, the new testosterone sustained from the aromasin just might set a new homeostasis (seeing as your T used to be there already). This is just my theory but who knows, it's definitely worth a shot. Good luck
 
Carth said:
Aromasin boosts Test?

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males

Nelly Mauras, John Lima, Deval Patel, Annie Rini, Enrico di Salle, Ambrose Kwok and Barbara Lippe

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P 0.002); 50 mg, 32% (P 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 ± 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.


Abbreviations: AUC, Area under the curve; CBC, cell blood count; HDL, high density lipoprotein; LDL, low density lipoprotein; PK, pharmacokinetic.
 
Jenetic said:
Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males

Nelly Mauras, John Lima, Deval Patel, Annie Rini, Enrico di Salle, Ambrose Kwok and Barbara Lippe

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P 0.002); 50 mg, 32% (P 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 ± 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.


Abbreviations: AUC, Area under the curve; CBC, cell blood count; HDL, high density lipoprotein; LDL, low density lipoprotein; PK, pharmacokinetic.

Excellent post J...Why was there less suppresion of E and less testosterone increases from the higher 50mg. dose?

This validates the safety issues I had with exemestane having possible permanent E suppresion. Plus the mean-elimination half-life of 8.9hrs is cofortable in case one needs to bail out, howerver time for development of new enzymes via the cyp 10 gene is unknown and follow-ups and further investigations need to be performed.

Btw..been a bit busy, but will contribute to your pct thread asap.

Peace...B32
 
Jenetic said:
The treatment has been going fantastic. My strength and endurance is significantly increasing every week. It's funny because it looks like I am making gains that a cycle would give me. No supplements involved including protein shakes. Only solid foods. I finally have what it takes again to sustain a full blown workout.

Kinda off topic for this thread -- but do you have something against shakes?

Just curious. I can say that when I diet, I usually discard shakes as a protein source -- it just feels better (I know that hardly qualifies as being scientific LOL); however while trying to add mass, its not uncommon for me to have 6-10 scoops of whey per day.

So whats your 2 cents on shakes?
 
psychedout said:
Kinda off topic for this thread -- but do you have something against shakes?

Just curious. I can say that when I diet, I usually discard shakes as a protein source -- it just feels better (I know that hardly qualifies as being scientific LOL); however while trying to add mass, its not uncommon for me to have 6-10 scoops of whey per day.

So whats your 2 cents on shakes?

I have nothing against shakes. It's considered a nutritional supplement. If I didn't have sufficient intake with my diet, I would add it in. Currently, my caloric needs are not that high, I prefer to eat whole foods and I'm in a country where they charge $100 for a bottle of name brand protein.

Jenetic
 
As a final update, I have finished my recovery treatment and my testosterone is back to 872. This blood test was taken 4 weeks after cessation of gonadotropin therapy.

Jenetic
 
Jenetic said:
As a final update, I have finished my recovery treatment and my testosterone is back to 872. This blood test was taken 4 weeks after cessation of gonadotropin therapy.

Jenetic

872 is quite high. Good shit:) What did your other levels normalize at?(free test, prolactin, estradiol..) Also would you mind detailing your complete recovery process from weeks 1- x?
 
Jenetic said:
As a final update, I have finished my recovery treatment and my testosterone is back to 872. This blood test was taken 4 weeks after cessation of gonadotropin therapy.

Jenetic

fucker

lets hope mine comes back around there :p
 
Jenetic said:
As a final update, I have finished my recovery treatment and my testosterone is back to 872. This blood test was taken 4 weeks after cessation of gonadotropin therapy.

Jenetic

Question is...do you plan on juicing again? Because if do, it really didn't make much sense in bringing your own test up. For what? To screw it up all over again? Get back to me on this. I would like to hear from you on this. Remember Jenetic...both you and I have the same problem. But mine has a solution.
 
Carth said:
Question is...do you plan on juicing again? Because if do, it really didn't make much sense in bringing your own test up. For what? To screw it up all over again? Get back to me on this. I would like to hear from you on this. Remember Jenetic...both you and I have the same problem. But mine has a solution.

What difference would it make if I decided to use or not?

What's your solution? Staying on permanently?

We don't have the same problem. I never considered suicide or harming another person during that period of time.

Jenetic
 
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Mr. Black said:
872 is quite high. Good shit:) What did your other levels normalize at?(free test, prolactin, estradiol..) Also would you mind detailing your complete recovery process from weeks 1- x?

The process of recovery included a combination of 5000 IU's HCG 3x/wk (mon/wed/fri), 150 IU's HMG 3x/wk (mon/wed/fri) and 20 mgs Nolvadex ED. Gradually, we decreased the dosages to 1500 IU's HCG 3x/wk (mon/wed/fri), 150 iu's HMG 3x/wk (mon/wed/fri) and 20 mgs Nolvadex ED. This was over the course of approximately 16 weeks. In addition, my condition was far more severe than the normal HTPA suppression encountered post cycle. There is usually no reason to use HMG or high and prolonged dosages of HCG.

I don't have my blood work results in front of me but everything is back to normal.

Jenetic
 
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Jenetic said:
The process of recovery included a combination of 5000 IU's HCG 3x/wk (mon/wed/fri), 150 IU's HMG 3x/wk (mon/wed/fri) and 20 mgs Nolvadex ED. Gradually, we decreased the dosages to 1500 IU's HCG 3x/wk (mon/wed/fri), 150 iu's HMG 3x/wk (mon/wed/fri) and 20 mgs Nolvadex ED. This was over the course of approximately 16 weeks.

I don't have my blood work results in front of me but everything is back to normal.

Jenetic

So, from experience, what would be your OPTIOMAL PCT paln that you would suggest EVERYONE to utilize? Let's say from a average 10 week dbol/test/deca cycle.............
 
JKurz1 said:
So, from experience, what would be your OPTIOMAL PCT paln that you would suggest EVERYONE to utilize? Let's say from a average 10 week dbol/test/deca cycle.............

Blood work should be performed before begining the cycle in order to establish baseline values.

During cycle, use an aromatase inhibitor such as aromasin, femara and arimidex when using aromatizing AAS and an anti prolactin such as dostinex or bromocriptine when using nandrolones. Minimize these levels before starting PCT to avoid uncessary side effects and delay in recovery.

1000-1500 IU's HCG 3x/wk (mon/wed/fri), 50-100 mgs Clomid ED and 20 mg Nolvadex ED for a total of 3 weeks. Continue with 50 mgs Clomid ED and 20 mgs Nolvadex ED for an additional 2-3 weeks followed by blood work to evaluate recovery.

Jenetic
 
Damn bro, I had no idea. Thanks for sharing this thread. It has been quite an eye opener. I am glad you decided to take the restoration route instead of going on HRT (the easy way out).

BTW, that was a freakin hella-cycle you were on.
 
Hi there Jenetic. I read your recovery story after 1.5 years and I think that's great. Since you've been going through this for a while now , perhaps you can help someone w/ a similar problem......My name is John Interian and I am 31 years old. I found you on the web after doing a search for doctors that have treated steroid induced hypogonadism. I saw that you were successful in reversing the condition w/out having to resort to using lifelong TRT or HRT w/ many patients. You're the only doctor that I have found thus far that seems to specialize in this. I truly need your help if at all possible.

My story is as follows. Back around Oct. of 2005 I naively did 2 cycles back to back of Deca Durabolin (100 & 200) to help a bad pec tear. I was doing 1cc a week for the 1st month and then 2cc's a week for the remainder. My last shot was on Dec.23 of 2005. I waited about 2 weeks and then I did 1cc of HCG for 10 days. That was it. I did no Clomid or Nolva. Before this I have never done a cycle of any anabolic steroid.


As you could guess a few weeks later I noticed I had no libido and had trouble sestaining erections. I immedietly went to my primary physician and had bloodwork done. Bloodwork showed that I had VERY low test levels (a reading of 108) and low LH and FSH . I also had a high red blood cell count. I was told to wait about 8 weeks for a follow up.

Soon I started to feel very lethargic, moody, and I found that I would fatigue very easily following any type of physical exertion.

About a month after my last HCG shot I began to take Tomaxophine Citrate to try and help raise my test. I knew it was late in the game, but I thought it was worth a try.I was taking around 40mg 1st 2 weeks, and tapered down to 30mg, 20mg, etc. That lasted around 8 weeks. I'm not sure if it's a side of the Tamaxo , but I was getting hot flashes, blurry vision, and now 2 weeks since I've taken it I still feel dizzy and light headed following any physical exertion. I also feel slower mentally and physically. I truly do not know if this is a symptom of low test or a side from the Tomaxo.

I have a follow up blood test tommorrow w/ my primary physician and an endo appointment on May 1st.

Although I have these appointments I fear that my doctors may offer little help as far as helping to restart my own natural test. My primary physician flat out admitted that he had no experience w/ steroid induced hypogonadism. We'll see what happens w/ my endo, but more than likely he may resort to lifelong TRT or HRT and I am trying to avoid this if possible.

What do you suggest if bloodwork comes back w/ negative feedback ? Should I just give my body more time ? It's been months and I've only been feeling worse. This has been affecting my entire life, both personal and at work. I want to feel better , but fear the risk of long term TRT.

Do you have any advice or references to good endo's in my area (Miami, Florida) that could treat my particular situation? Perhaps some resources or leads ?

I see that you've found a good doctor who is open minded and willing to work w/ you on this. I've had a VERY hard time even finding anyone in Florida who is even remotely knowledgeable w/ helping someone w/ steroid induced hypogonadism get their own test back up and running. What state do you live in ? I was thinking that maybe I could contact your doctor and see if maybe he would be willing to help me or work w/ my doctor. Please get back to me and let me know what you think. I appreciate your time. Thankyou.

-John
 
Also you mentioned that it's normally not necessary to use such high and prolonged doses of HCG. So what is the normal dosage, how often, and for how long ??
 
Jenetic said:
Blood work should be performed before begining the cycle in order to establish baseline values.

During cycle, use an aromatase inhibitor such as aromasin, femara and arimidex when using aromatizing AAS and an anti prolactin such as dostinex or bromocriptine when using nandrolones. Minimize these levels before starting PCT to avoid uncessary side effects and delay in recovery.

1000-1500 IU's HCG 3x/wk (mon/wed/fri), 50-100 mgs Clomid ED and 20 mg Nolvadex ED for a total of 3 weeks. Continue with 50 mgs Clomid ED and 20 mgs Nolvadex ED for an additional 2-3 weeks followed by blood work to evaluate recovery.

Jenetic

Hi Madball....Read above!
 
Jenetic said:
The process of recovery included a combination of 5000 IU's HCG 3x/wk (mon/wed/fri), 150 IU's HMG 3x/wk (mon/wed/fri) and 20 mgs Nolvadex ED. Gradually, we decreased the dosages to 1500 IU's HCG 3x/wk (mon/wed/fri), 150 iu's HMG 3x/wk (mon/wed/fri) and 20 mgs Nolvadex ED. This was over the course of approximately 16 weeks. In addition, my condition was far more severe than the normal HTPA suppression encountered post cycle. There is usually no reason to use HMG or high and prolonged dosages of HCG.

I don't have my blood work results in front of me but everything is back to normal.

Jenetic

At what point did you decrease your dosage of the HCG?
Did you decrease immediatly from 5000iu to 1500iu or did you 2500iu in between?
Thanks
 
artificialaspirations said:
I wonder if jenetic's test level is still 872? It sounds like he did this for 4 months?
i was wondering why you are BUMPING TWO YEAR OLD THREADS!!!!!!!!
 
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