tren and gyno just don't mix!!!

[da big thinker]

Tren's binding affinity to PR is about the same as progesteron itself. Study was posted on a board plenty of times.

if we are talking about the same study...well,it did not give enough evidence IMO;there was no evidence that tren exerted the effects through the PR receptor...

 

[da big thinker]

I have seen guys on this board get gyno from fina alone, and also from fina/winny. Winny is not a fail-safe. And fina can cause gyno whether can comprehend it or not. And it is progesterone. And I have read the study where it does bind with the progesterone receptor.

Damn, why not start a thread that deca can't cause gyno, because that argument holds just as much water.

well TX i'm trying to comprehend it;please show me the study that contradicts my statement in my initial post,where tren cannot fit in the PR receptor.i beleive this to be fact...in addition,i don't see any need to compare tren w/ deca...two different compounds my friend.this thread will remain about tren...

 

[da big thinker]

I have seen guys on this board get gyno from fina alone, and also from fina/winny. Winny is not a fail-safe. And fina can cause gyno whether can comprehend it or not. And it is progesterone. And I have read the study where it does bind with the progesterone receptor.

Damn, why not start a thread that deca can't cause gyno, because that argument holds just as much water.

tx,

the reason i am trying to figure this out is because i used deca and did obtain PR gyno post cycle;it subsided immediatelly after using winny...fina has not affected me in any way...even users like brother val reported gyno w/ deca...but not w/ fina...just trying to clear this up...---fyi

 

[panerai]

Mega, is it you?

 

[frankie21]

so one more time ....How do you prevent gyno while on fina? Yes Winny helps, but what else do ya recommend for those who are sensitive and what dosage?

 

[panerai]

By stop using it, soon as you see first signs of gyno. It's fast acting, in and out very quickly.

 

[panerai]

if we are talking about the same study...well,it did not give enough evidence IMO;there was no evidence that tren exerted the effects through the PR receptor...

Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor.

APMIS 2000 Dec;108(12):838-46 (ISSN: 0903-4641)

Bauer ER; Daxenberger A; Petri T; Sauerwein H; Meyer HH [Find other articles with these Authors]
Institut fur Physiologie, Research Center for Milk and Food Weihenstephan, Technical University Munich, Germany.

For the steroidal growth promoters trenbolone acetate (TBA) and melengestrol acetate (MGA) neither the complete spectrum of biological activities nor the potential endocrine disrupting activity of their excreted metabolites in the environment is fully understood. The potency of these substances in [3H]dihydrotestosterone ([3H]-DHT) displacement from the recombinant human androgen receptor (rhAR) and from human sex-hormone binding globulin (hSHBG) was evaluated. In addition, the potency for [3H]-ORG2058 displacement from the bovine uterine progestin receptor (bPR) was tested. For comparison, different anabolics and synthetic hormones were also tested for their binding affinities. For 17beta-trenbolone (17beta-TbOH), the active compound after TBA administration, an affinity the rhAR similar to dihydrotestosterone (DHT) and a slightly higher affinity to the bPR than progesterone were demonstrated. The affinity of the two major metabolites, 17alpha-trenbolone and trendione, was reduced to less than 5% of the 17beta-TbOH-value. The affinity of these three compounds and of MGA to the hSHBG was much lower compared with DHT. MGA showed a 5.3-fold higher affinity than progesterone to the bPR but only a weak affinity to the rhAR. The major MGA metabolites have an affinity to the bPR between 85% and 28% of the affinity of progesterone. In consequence, MGA and TBA metabolites may be hormonally active substances, which will be present in edible tissues and in manure. We conclude that detailed investigations on biodegradation, distribution and bio-efficacy of these substances are necessary.
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What do you mean "not enough evidence"?
The study is clear about binding affinity of Tren to PR. Now, by being not sure about how it activates PR, you, probably meant if it is agonist of PR or antagoinst.
Well, it's not that complecated to prove that Tren is agonist.
As you can see from the same study, Tren's affinity to AR is the same as DHT, which means that all the users should experience "hard on" effect from Tren alone cycles, and it has to be much stronger then from Test or even Test+high dosage of Proviron combo. What do we get in real life? With few exceptions, most users experience Fina dick, or close to it, and definately nothing even close to pure DHT effect.
Why? Same as with Deca - binding to PR. That's the only possible explanation.

Now, you started that thread, saying that Tren when viewed from 3-D can't fit in PR, so how come it does?
Get your facts together.

Trenbolone and Nandrolone, both are progestogens, both derivated from 19-nortestosteron.
Tren - 4,9,11-Estratrien-17beta-ol-3-one
Nandrolone - 4-Estren-17beta-ol-3-one

Don't you see striking similarities? So, comparing these two compouds make a lot of sense.

 

[panerai]

i TREN itself and its metabolites,when viewed as a three-dimensional molecule,cannot fit in the PR receptor.

That's very interesting. Can you, please, post links to images of Tren and metabolites in 3D, and also PR receptor, and explain how you figure all this out?
Or, in a matter of fact, any solid information that backs that statement up.

 

[NewGuy1980]

Not part of the debate, but cant u just take armidex (like .5mg a day) during cycle and clomid post cycle to avoid Gyno altogether on any AS???

 

[panerai]

Not part of the debate, but cant u just take armidex (like .5mg a day) during cycle and clomid post cycle to avoid Gyno altogether on any AS???

No, you can't. Arimidex is aromatise inhibitor and will work only with aromatics, and those are Testostero, Dianabol, Equipoise.
Nandrolone does convert to estrogen a little(approx 20% comparing to Testosteron) but not via aromatisation.
But, Nandrolone and Trenbolone, as well as Anadrol can cause gyno, by cross binding to Progesteron receptor. No aromatisation there, neither.