Here's a snipet from Mr. X's bulking basics 2 article:
Lower calorie intake enhances muscle insulin action and reduces hexosamine levels
Annie C. Gazdag1, Thomas J. Wetter2, Robert T. Davidson1, Katherine A. Robinson3, Maria G. Buse3, Alice J. Yee4, Lorraine P. Turcotte4, and Gregory D. Cartee1,2
Biodynamics Laboratory, Departments of 1 Nutritional Sciences and 2 Kinesiology, University of Wisconsin, Madison, Wisconsin 53706; 3 Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425; and 4 Department of Exercise Sciences, University of Southern California, Los Angeles, California 90089
Previous studies have demonstrated enhanced insulin sensitivity in calorie-restricted [CR, fed 60% ad libitum (AL) one time daily] compared with AL-fed rats. To evaluate the effects of reduced food intake, independent of temporal differences in consumption, we studied AL (unlimited food access)-fed and CR (fed one time daily) rats along with groups temporally matched for feeding [fed 3 meals (M) daily]: MAL and MCR, eating 100 and 60% of AL intake, respectively. Insulin-stimulated glucose transport by isolated muscle was increased in MCR and CR vs. AL and MAL; there was no significant difference for MCR vs. CR or MAL vs. AL. Intramuscular triglyceride concentration, which is inversely related to insulin sensitivity in some conditions, did not differ among groups. Muscle concentration of UDP-N-acetylhexosamines [end products of the hexosamine biosynthetic pathway (HBP)] was lower in MCR vs. MAL despite unaltered glutamine-fructose-6-phosphate aminotransferase activity (rate-limiting enzyme for HBP). These results indicate that the CR-induced increase in insulin-stimulated glucose transport in muscle is attributable to an altered amount, not timing, of food intake and is independent of lower triglyceride concentration. They further suggest that enhanced insulin action might involve changes in HBP.
I am pretty sure of the fact that you do not have to understand the study itself, all you need to do is take a look at the title. Now, we are clear on the fact: Lower Calorie intake enhances muscle insulin action and reduces hexosamine levels. The main point of this would be the “INCREASE IN MUSCLE INSULIN ACTION”, which at first sight might seem like the newest bullshit fad in dieting, but I’ll be frankly honest with you: it’s totally true. As a result, I will base my Simple-Bulking Up-Part 2 on this study, and I will lead you the reader to a revolutionary way of bulking…let’s call it, just for the purpose of this article, cycle-bulking.
The name, Cycle-Bulking, should pretty much explain itself, basically you cycle your calories from low to high for maximum results, yet this differs from Protein/Carb Cycling because the way we are looking at this is NOT carb/protein but more of a overall calories intake. Since, we know that low-calories will induce better insulin action, and high-calories will put on mass, I would say this is the perfect combination for the average-bodybuilder to put on mass.
Let’s begin by looking at the way you can cycle your calories, and why…First, you must understand that you need pre and post workout nutrition to grow and, therefore, I do not recommend going low-cal on your training days. Instead, you follow the simple equation: workout=high-calories…no workout=low-calories