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Test Kills brain cells?
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SgtSlaughter
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depends on what your type is...samoth said:I hear MIT has the hottest chicks in the country.
Elevated Testosterone Kills Brain Cells
Main Category: Endocrinology News
Article Date: 28 Sep 2006 - 16:00 PST
A Yale School of Medicine study shows for the first time that a high level of testosterone, such as that caused by the use of steroids to increase muscle mass or for replacement therapy, can lead to a catastrophic loss of brain cells.
Taking large doses of androgens, or steroids, is known to cause hyperexcitability, a highly aggressive nature, and suicidal tendencies. These behavioral changes could be evidence of alterations in neuronal function caused by the steroids, said the senior author, Barbara Ehrlich, professor of pharmacology and physiology.
"Next time a muscle-bound guy in a sports car cuts you off on the highway, don't get mad, just take a deep breath and realize that it might not be his fault," said Ehrlich.
Testosterone is the main male hormone and it plays fundamental roles in development, differentiation, and cellular growth. In neurons, testosterone acts as a neurosteroid and can induce changes at the cellular level, which in turn lead to changes in behavior, mood and memory. Both neuroprotective and neurodegenerative effects of androgens have been reported.
The researchers showed that high levels of testosterone triggered programmed cell death in nerve cells in culture. Cell death, or apoptosis, is critical in many life processes, including development and disease. It is characterized by membrane instability, activation of caspases, which are the executioner proteins in apoptosis, change in membrane potential, and DNA fragmentation.
"In the present study we have demonstrated for the first time that the treatment of neuroblastoma cells with elevated concentrations of testosterone for relatively short periods, six to 12 hours, induces a decrease in cell viability by activation of a cell death program," Ehrlich said. "Low concentrations of testosterone had no effects on cell viability, whereas at high concentrations the cell viability decreased with incremental increases in hormone concentration."
The testosterone-induced apoptosis described in this study occurs through overactivation of intracellular Ca2+ signaling pathways. Overstimulation of the apoptotic program in neurons has been associated with several neurological illnesses, such as Alzheimer disease and Huntington disease.
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Co-authors include Manuel Estrada, now continuing his work at the University of Chile in Santiago, and Anurag Varshney, now working at Ranbaxy, a drug discovery company in New Delhi, India.
Journal of Biological Chemistry 281: 25492-25501 (September 2006)
Contact: Jacqueline Weaver
Sounds somewhat prejudice... we'd really have to see the full article for details.
Main Category: Endocrinology News
Article Date: 28 Sep 2006 - 16:00 PST
A Yale School of Medicine study shows for the first time that a high level of testosterone, such as that caused by the use of steroids to increase muscle mass or for replacement therapy, can lead to a catastrophic loss of brain cells.
Taking large doses of androgens, or steroids, is known to cause hyperexcitability, a highly aggressive nature, and suicidal tendencies. These behavioral changes could be evidence of alterations in neuronal function caused by the steroids, said the senior author, Barbara Ehrlich, professor of pharmacology and physiology.
"Next time a muscle-bound guy in a sports car cuts you off on the highway, don't get mad, just take a deep breath and realize that it might not be his fault," said Ehrlich.
Testosterone is the main male hormone and it plays fundamental roles in development, differentiation, and cellular growth. In neurons, testosterone acts as a neurosteroid and can induce changes at the cellular level, which in turn lead to changes in behavior, mood and memory. Both neuroprotective and neurodegenerative effects of androgens have been reported.
The researchers showed that high levels of testosterone triggered programmed cell death in nerve cells in culture. Cell death, or apoptosis, is critical in many life processes, including development and disease. It is characterized by membrane instability, activation of caspases, which are the executioner proteins in apoptosis, change in membrane potential, and DNA fragmentation.
"In the present study we have demonstrated for the first time that the treatment of neuroblastoma cells with elevated concentrations of testosterone for relatively short periods, six to 12 hours, induces a decrease in cell viability by activation of a cell death program," Ehrlich said. "Low concentrations of testosterone had no effects on cell viability, whereas at high concentrations the cell viability decreased with incremental increases in hormone concentration."
The testosterone-induced apoptosis described in this study occurs through overactivation of intracellular Ca2+ signaling pathways. Overstimulation of the apoptotic program in neurons has been associated with several neurological illnesses, such as Alzheimer disease and Huntington disease.
###
Co-authors include Manuel Estrada, now continuing his work at the University of Chile in Santiago, and Anurag Varshney, now working at Ranbaxy, a drug discovery company in New Delhi, India.
Journal of Biological Chemistry 281: 25492-25501 (September 2006)
Contact: Jacqueline Weaver
Sounds somewhat prejudice... we'd really have to see the full article for details.
redsamurai
Banned
I still call bullshit.........it's just like growing up when I was told how stupid weed makes you. Yet the most profound spiritual and intellectual experiences of my life are a result of marijuana use. Now, I'm not a pot head that smokes every day......in fact, I don't smoke anymore because I want to keep my lungs clean......but I take my weed other ways.
SgtSlaughter
New member
If you're saying some people of a lesser intelligence that smoke pot, naturally will be of lesser intelligence during and after smoking green I agree.redsamurai said:
And that goes for most things. Study's are skewed.
I bet someone could find the antithesis to that study with 5 minutes of goggling.
Do you inject your mary jane now?
macrophage69alpha
New member
samoth said:
perhaps now we'll be eligible for ADA protection
redsamurai
Banned
hell yeah...I'm free basin that shit now!! and don't even get me started on the "green suppositories"!!!
Sarge_ said:If you're saying some people of a lesser intelligence that smoke pot, naturally will be of lesser intelligence during and after smoking green I agree.
And that goes for most things. Study's are skewed.
I bet someone could find the antithesis to that study with 5 minutes of goggling.
Do you inject your mary jane now?
marvelous54
New member
golferstud84 said:
Yeah that's why no one lives past the age of 16. Our test levels get to high and we just die. Were all just elecrical pulses now.
How can any fucking responsible person write a fucking article like that? They act like taking test just all of a sudden makes you super natural and your body just can't take it.
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