With the mixture of esters in Sust, it's a good first choice IMHO. Due to it's content of Prop you may want to shoot it eod to keep blood levels even. If you were only planning on doing 250mg/wk you could split it up into three shots and shoot MWF... Kind of a pain in the ass (literally), but will result in more even blood levels. Some say it can be shot twice a week, but the prop will not be administered evenly this way, although it won't matter much for the other esters. You pick. I still think it's one of the best choices if it's all you're going to use. On 250 a week you can make solid gains. Eat clean, and train hard, don't worry about an anti-e unless you're prone (although I guess you really don't know if you are or not so it wouldn't hurt to have nolva on hand in case you are...well worth the cash and you'll need it on hand for the 2nd cycle you mentioned anyway).