You'll have to excuse be because the only "cylcles" I know of are monthly female ones BUT...I can tell you that Accutane does not cure Ance forever. It definately can and does come back. I was on it twice and still have a few challenges to this day. So, I venture to say yes, you could break out again.goodbroo said:So if you have used accutane before, did you get bad acne or any acne at all when you cicled again, after the treatment ?