Myostat blockers

[hard2handle]

I haven't heard much about his for awhile. Search pulled last thread in 06. Very interesting info on this topic. Anyone have data on this supp?

Nelson,I would appreciate input on this, this seems up your alley.

 

[hard2handle]

anyone?

 

[Nelson Montana]

Bogus. It's based on some sketchy reserach. It DOES work, but, the stuff used in supplements was a watered down (worthless) plant based imitation of the drug. (Kinda like phytosterols trying to be steroids). The supps were popular for a minute but everyone caught on --- the manufacturers had to fess up -- and they're all but gone from the market. Anything you see on the shelves is left over.

 

[hard2handle]

So is there a drug? Can it be purchased? Or is that sourcing?

 

[hard2handle]

Ok, I found the drug. ACVR2B(activin A receptor type 2B). This is the newer compound, upgrade from the original MYO-029. It does appear to be available to labs. Has anyone heard of any bbs using this stuff?

 

[hard2handle]

Oh, thanks for response Nelson

 

[b_light]

I thought there was nothing out yet that could achieve this.

 

[hard2handle]

I'm in the gray here, but the articles I found say this new acvr2b is the real deal. Working in 2 weeks. It is available through pharmaceutical suppliers now.

 

[SpyWizard]

I think the issue is the compound is so fragile it is very difficult to transport.. cryo free and all..

 

[Anthony Roberts]

There's a protein powder which lowers Myostatin....

 

[hard2handle]

Thanks wiz,
Anthony go on...

 

[b_light]

yes, do tell.

 

[Anthony Roberts]

ABSORPTION PROFILE AND HORMONAL INFLUENCES OF Fertilized EGG YOLK INGESTION IN THE HUMAN
Journal of the American College of Nutrition, Volume 25, Number 5, October 2006
Colker, C. Peak Wellness, Inc. Greenwich, CT

Fertile egg yolks contain significant concentrations of follistatin. In an effort to identify whether this orally ingested source of naturally occurring follistatin is actually absorbed and pharmacokinetically active in the human model, this study was undertaken.

A male subject was chosen because the normal baseline male physiology does not regularly contain any measurable concentration of follistatin. Follistatin-rich fertile egg yolk powder properly processed to preserve active follistatin (FolstaxanTM) was obtained (Celldyne Biopharma, San Antonio, TX). After initial blood draw and subsequential oral Folstaxan dosing, serum follistatin levels were qualitatively and quantitatively) measured as an indicator of absorption. In addition, since we know follistatin is a negative modulator of myostatin, serum myostatin levels were qualitatively and quantitatively measured as an indication of hormonal influence and thus true pharmacokinetic activity. Testing utilized purchased follistatin and myostatin standardized for verification. Confirmations were run by ELISA and quantitations by Liquid Chromatography Tandem Mass Spectrometer with third degree fragmentation (Expertox, Deer Park, TX).

Results showed as predicted, a zero level of follistatin at baseline with a myostatin level of 46 pg/ml, 12 hours after FolstaxanTM dosing. Serum follistatin measured 57.1 pg/ml with a decline of myostatin to 34 pg/m1, 24 hours after the initial dosing, follistatin levels began to predictably drop from the time of initial dosing to 11.4 pg/ml. Yet myostatin continued to decline slightly with a 24-hour level of 31 pg/ml. These results clearly indicate that a fertile egg yolk powder properly processed to preserve active follistatin, when orally ingested, results in detectable serum follistatin. Furthermore, this resultant follistatin presence has significant pharmacokinetic activity is shown by the hormonal down regulation of serum follistatin.

 

[b_light]

something must not add up with it or else everyone would be all over this stuff.

 

[Anthony Roberts]

something must not add up with it or else everyone would be all over this stuff.

Honestly, it was an obscure study buried in medline until Carl Lanore (Host of SuperHumanRadio.com) found it, and interviewed someone form the company producing it.

SuperhumanRadio, by the way, is also where Fadogia (MyoGenX) came from, and the host will have his own column in the upcoming magazine I'm writing for (I'm senior Editor).

 

[b_light]

Well im sure once it goes public if it hasn't yet it will be pretty big but 99% of stuff like this ends up being crap like endothil, etc.

 

[hard2handle]

Ok so follistatin, is the anti myostatin? That seams to simple.
Is there any reason why you wouold not eat real egg yolks then? I mean instead of powder.
Oh and thanks Anthony, good read.

 

[hard2handle]

Anthony, sounds like I should check out your magazine. Is it about stuff like this. I mean intelligent, not just meathead talk.