Melatonin & kidney failures

[anthrax]

Melatonin reduces kidney failure
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2000, Vol 279, Iss 5, pp F910-F918


A recent study evaluated the effect of melatonin, a potent free radical scavenger, on mercury-induced kidney failure. Rats received 1 mg/kg of melatonin or placebo, 30 min before the mercury (mercuric chloride). Melatonin pretreatment (melatonin blood levels of 3 mg/ml at the time of mercury administration) prevented the increment in blood creatinine and reduced death of kidney tubules from 41 to 4.2! In the group untreated with melatonin, apoptosis (cell death) and post necrotic proliferative activity (the sum of morphological changes indicative of cell death and caused by the progressive degradative action of enzymes) were twice more intense. Melatonin prevented an increase in kidney content of malondialdehyde (MDA, stress marker) and decrease in glutathione (GSH) resulting from mercury toxicity. Melatonin also induced an important reduction in superoxide-positive cells. Thus, the beneficial effects of pharmacological doses of melatonin in kidney disease are due to its antioxidant properties.

 

[Kai Hvatum]

That's an insanely high dosage. Any dosage of Melatonin over .5 mg will disturb your sleep. I would recommend starting with .3 mg and then going up from there. Although I am a bit on the light side (145).

 

[anthrax]

That's an insanely high dosage. Any dosage of Melatonin over .5 mg will disturb your sleep. I would recommend starting with .3 mg and then going up from there. Although I am a bit on the light side (145).

????

The average pills are either 1 mg or 3 mg
and they are supposed to help fight insomnia

 

[Kai Hvatum]

The average melatonin pills have dosages that are far too high.

Most Melatonin Pills are crap because they're exactly that, pills. The absorption is too slow, it takes about an hour to hit. For absorption that slow you obviously need a higher dosage to actually get to sleep. The body however never produces that much Melatonin, and having too much will make your sleep restless. You'll be on the edge of a really disturbed REM sleep until the level lowers.

Better is a .3 mg Sublingual dosage. You'll be out cold in 15 minutes .

A higher dosage might work if it were formulated as some kind of slow release pill, so your melatonin levels would never reach a really high level.

 

[wtlftr]

I take sublingual mealtonin 15 mg 30 minutes prior to sleep. I tried 20mg but had sleep dream disorders

 

[TJ4]

The average melatonin pills have dosages that are far too high.

Most Melatonin Pills are crap because they're exactly that, pills. The absorption is too slow, it takes about an hour to hit. For absorption that slow you obviously need a higher dosage to actually get to sleep. The body however never produces that much Melatonin, and having too much will make your sleep restless. You'll be on the edge of a really disturbed REM sleep until the level lowers.

Better is a .3 mg Sublingual dosage. You'll be out cold in 15 minutes .

A higher dosage might work if it were formulated as some kind of slow release pill, so your melatonin levels would never reach a really high level.

Well, I can only speak for myself but I have tried taking a 3mg capsule and only using a third and then a half of the contents and it never worked well on me when I couldnt sleep. However, when I take the entire 3 mg cap it knocks me out in about 10 min. The first time I did this I had the best nights sleep I have ever had and I woke up on time feeling rested and AWAKE, which is not common with me and now I have the same experience every time I take it. I know it must not work on everyone but that's just my personal experience with it.

 

[youlikadajuice]

I tried 9mg, that didnt do anything for me. Fell asleep just as fast without them.