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MACRO/ULTER........Testing a new Aromatese Inhibitor Formula:

JS27 said:
Nothing herbal is going to come close to anastrozole for reducing estrogen levels.

Sorry to state the obvious, but that needs to be said.

If you're worried about your lipid levels, then don't use an aromatase inhibitor (i.e. Arimidex and Femara).

You can use exemestane instead. or if that is too expensive Novaldex.

Best bet is Novaldex. As it is a weak estrogen, it will help in keeping your lipid levels normal.

its not herbal. its a naturally occuring steroidal aromatase inhibitor.
 
macrophage69alpha said:
its not herbal. its a naturally occuring steroidal aromatase inhibitor.

Emphasis on "naturally occuring" :)

Lets be completely candid here....it's potency is not even going to come
close to that of Anastrozole.

It's a bit irresponsible to claim that it's effects will be comparable to A-dex.

This whole thing is starting to remind me of the whole "Chrysin" Debacle a few years ago.
 
JS27 said:
Emphasis on "naturally occuring" :)

Lets be completely candid here....it's potency is not even going to come
close to that of Anastrozole.

It's a bit irresponsible to claim that it's effects will be comparable to A-dex.

This whole thing is starting to remind me of the whole "Chrysin" Debacle a few years ago.

actually its more potent
not really
they are not comparable

all of the steroidal based aromatase inhibitors, including exemstane are based on the active which is ATD
 
swordfish151 said:
hmm...no answer...looks like macro wins again LOL

Please realize that most people do not spend all day in front of the computer.

In any case,

ATD = androst-1,4,6-triene-3,17-dione

It's basically a androstenedione analogue. A C-19 Steroid.

Exemestane for example is methyleneandrost-4-ene-3,17-dione. The methylation increases it's oral bio-availibility drastically. Also it's anti-estrogenic activity.

To say that ATD works well in humans is quite a stretch. It's structure
hasn't been sufficiently manipulated to ensure a high enough anti-estrogenic activity.

I would describe it's potency as follows:

ATD is to Arimidex, as DHEA is to testosterone.

If you manipulated the molecular structure some more, you could come up with some far more potent compounds, but then the pharmaceutical companies would have already done so.

The only reason they did not, is that ATD is considered a naturally-occuring compund and is covered under the Hatch Act. (Where all naturally occuring substances cannot be patented. (GHB being the big exception)
 
JS27 said:
Please realize that most people do not spend all day in front of the computer.

In any case,

ATD = androst-1,4,6-triene-3,17-dione

It's basically a androstenedione analogue. A C-19 Steroid.

Exemestane for example is methyleneandrost-4-ene-3,17-dione. The methylation increases it's oral bio-availibility drastically. Also it's anti-estrogenic activity.

To say that ATD works well in humans is quite a stretch. It's structure
hasn't been sufficiently manipulated to ensure a high enough anti-estrogenic activity.

I would describe it's potency as follows:

ATD is to Arimidex, as DHEA is to testosterone.

If you manipulated the molecular structure some more, you could come up with some far more potent compounds, but then the pharmaceutical companies would have already done so.

The only reason they did not, is that ATD is considered a naturally-occuring compund and is covered under the Hatch Act. (Where all naturally occuring substances cannot be patented. (GHB being the big exception)

Im just enjoying the debate my friend..good information
 
JS27 said:
Exemestane for example is methyleneandrost-4-ene-3,17-dione. The methylation increases it's oral bio-availibility drastically. Also it's anti-estrogenic activity.

yes and no.

if you had actually done a search on pubmed you would realize that the potency is similar, oral bioavailability is the issue. Hence why its a topical (aka transdermal) formulation.

just to clarify exemestane is not an anti-estrogen, its an aromatase inhibitor-- a suicidal one- the same as ATD.

in point of fact anti-estrogen is a often used misnomer. example nolvadex and clomid are not anti-estrogens they are SERMs.
 
JS27 said:
If you manipulated the molecular structure some more, you could come up with some far more potent compounds, but then the pharmaceutical companies would have already done so.

The only reason they did not, is that ATD is considered a naturally-occuring compund and is covered under the Hatch Act. (Where all naturally occuring substances cannot be patented.

manipulating the structure is how they came up with exemestane. The reason that ATD was not developed was because it was not patentable. Most, if not all pharmaceutical development is based on patentability and hence profitability. Effectiveness comes a distant second.
 
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