List of supplements that supposedly lower your SHBG levels!!

[FreakMonster]

Hey Nelson, does Nolvadex do anything to SHBG? If I take 20mg Nolvadex while using dbol for a while to prevent gyno, will I also be increasing SHBG?

According to this study it says that Nolvadex does increase SHBG:

Trait anxiety and tamoxifen effects on bone mineral density and sex hormone- binding globulin.

Cameron LD, Leventhal H, Love RR, Patrick-Miller LJ.

Department of Psychology, Faculty of Science, University of Auckland, Auckland, New Zealand. [email protected]

OBJECTIVE: Tamoxifen therapy preserves BMD of the lumbar spine and increases levels of SHBG. We assessed whether trait anxiety, a factor linked with a reactive endocrine system, is associated with differential changes in BMD and SHBG levels in response to tamoxifen therapy. METHODS: Postmenopausal women (N= 140) with axillary-node-negative breast cancer participated in a 2-year randomized, double-blind, placebo-controlled trial of tamoxifen (10 mg twice a day). Levels of BMD and SHBG were assessed at baseline and at 3, 6, 12, 18, and 24 months. RESULTS: Trait anxiety predicted tamoxifen-induced changes in lumbar spine BMD; high levels of trait anxiety were associated with significantly greater lumbar spine BMD at 3, 12, and 24 months (p values <.05) for women on tamoxifen therapy. High anxiety also was associated with lower levels of SHBG for women using tamoxifen at 3, 12, 18, and 24 months (p values <.05). CONCLUSIONS: Trait anxiety is associated with greater preservation of lumbar spine BMD in response to tamoxifen and with a suppression of tamoxifen-induced increases in SHBG. Trait anxiety and other affective traits may serve as indicators of underlying physiological processes that moderate the effects of estrogen receptor modulators (such as tamoxifen) in clinical trials. Such data may help to elucidate the physiological mechanisms responsible for some of the variation in individual responses to treatment.

 

[WARBIRDWS6]

According to this study it says that Nolvadex does increase SHBG:

Trait anxiety and tamoxifen effects on bone mineral density and sex hormone- binding globulin.

Cameron LD, Leventhal H, Love RR, Patrick-Miller LJ.

Department of Psychology, Faculty of Science, University of Auckland, Auckland, New Zealand. [email protected]

OBJECTIVE: Tamoxifen therapy preserves BMD of the lumbar spine and increases levels of SHBG. We assessed whether trait anxiety, a factor linked with a reactive endocrine system, is associated with differential changes in BMD and SHBG levels in response to tamoxifen therapy. METHODS: Postmenopausal women (N= 140) with axillary-node-negative breast cancer participated in a 2-year randomized, double-blind, placebo-controlled trial of tamoxifen (10 mg twice a day). Levels of BMD and SHBG were assessed at baseline and at 3, 6, 12, 18, and 24 months. RESULTS: Trait anxiety predicted tamoxifen-induced changes in lumbar spine BMD; high levels of trait anxiety were associated with significantly greater lumbar spine BMD at 3, 12, and 24 months (p values <.05) for women on tamoxifen therapy. High anxiety also was associated with lower levels of SHBG for women using tamoxifen at 3, 12, 18, and 24 months (p values <.05). CONCLUSIONS: Trait anxiety is associated with greater preservation of lumbar spine BMD in response to tamoxifen and with a suppression of tamoxifen-induced increases in SHBG. Trait anxiety and other affective traits may serve as indicators of underlying physiological processes that moderate the effects of estrogen receptor modulators (such as tamoxifen) in clinical trials. Such data may help to elucidate the physiological mechanisms responsible for some of the variation in individual responses to treatment.

oh fuck, i'm taking that too for my titties. maybe i'll crush it up with the andractim gel like clobro does...and get localized effect only for the most part on the nipples. was hoping to take it all the cycle through....but i'll stop it after dbol if it is a bad guy.

 

[Nelson Montana]

Silient: Good post. But even with that evidence it becomes a "chicken and the egg" scenario. If lower IGF-1 is what raises SHBG as we age...why does our IGF-! get lower?

Bottom Line: We get older. It does give further validy for the need for resistance exercise and the dismissal of aerobic exercise since resistance increases GH release and aerobics can lower IGF-!.

Anxiety raises SHBG. Does this mean that benzos lower it? Hmmmm.

plornive: Yes, Nolvadex, which is similar to Clomid , will raise SHBG. (Could be due to supposed lowered IGF as a matter of fact) Studies show this to be true but so does a more accurate barometer -- my dick. Nolva is another libido killer which decreases semenal volume. Nolvadex blows as bad as CLomid. The option is pretty simple. Just use less of what causes the problems that Nolva fixes.

 

[FreakMonster]

If proviron is so beneficial, why dont we use it with every cycle?

Probably because of the price.

 

[FreakMonster]

Didn't like the Nettles (Utica Diorca) because it lowers DHT which kills the libido highening effect.

But if your taking Proviron with Nettles wouldn't DHT levels stay the same?

It is also well known that taking Proviron can make you lose hair. Taking Nettle should help with that.

 

[FreakMonster]

same as I got bro, napped 7 bottles ...going to use that with nettle and Muira Puama

hey can't hurt for under 100 bucks

Do you know how many bottles of Muira Puama and Nettle I should get to last me for 8 weeks?

 

[FreakMonster]

Anyone heard of Paul Cribb? He states that benefiting from lower SHBG levels is a complete crock of shit. Below is the link:
http://www.ast-ss.com/dev/qa_search/full_text.asp?ID=763

 

[FreakMonster]

Here are 2 studies showing the binding affinity of Stinging nettle to SHBG



Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).

Schottner M, Gansser D, Spiteller G.

Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.

Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).


The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes.

Hryb DJ, Khan MS, Romas NA, Rosner W.

Department of Medicine, St. Luke's/Roosevelt Hospital Center, New York, N.Y. 10019.

Extracts from the roots of the stinging nettle (Urtica dioica) are used in the treatment of benign prostatic hyperplasia. The mechanisms underlying this treatment have not been elucidated. We set out to determine whether specific extracts from U. dioica had the ability to modulate the binding of sex hormone-binding globulin to its receptor on human prostatic membranes. Four substances contained in U. dioica were examined: an aqueous extract; an alcoholic extract; U. dioica agglutinin, and stigmasta-4-en-3-one. Of these, only the aqueous extract was active. It inhibited the binding of 125I-SHBG to its receptor. The inhibition was dose related, starting at about 0.6 mg/ml and completely inhibited binding at 10 mg/ml.

PMID: 7700987 [PubMed - indexed for MEDLINE]

 

[Judo Tom]

plornive: Yes, Nolvadex, which is similar to Clomid , will raise SHBG. (Could be due to supposed lowered IGF as a matter of fact) Studies show this to be true but so does a more accurate barometer -- my dick. Nolva is another libido killer which decreases semenal volume. Nolvadex blows as bad as CLomid. The option is pretty simple. Just use less of what causes the problems that Nolva fixes.

hey nelson.. i really enjoy some of the points you have brought up.. especially when they go against some of the things that people believe to be TRUTHS...

my question is if nolva/clomid blows.. what would you recommend post cycle.. just hcg hcg/ with proviron? or another anti e?

thanks

 

[WARBIRDWS6]

Anxiety raises SHBG. Does this mean that benzos lower it? Hmmmm.

i take two 10mg valiums a day....GH release and SHBG lowering. wonderful if true! BTW, i take every drug and supplement known to man if no one noticed yet.