IM may provide more local muscle growth, but as far as overall effectiveness. there appears to be no difference. lipoatrophy is an issue with igf, hgh and insulin(at least in type1 diabetics) when subQ is used (though some people want it

)
as a note- HCG is MORE effective subQ, unless you are obese....
1: Fertil Steril. 2003 Apr;79(4):881-5. Links
Subcutaneous versus intramuscular administration of human chorionic gonadotropin during an in vitro fertilization cycle.Stelling JR, Chapman ET, Frankfurter D, Harris DH, Oskowitz SP, Reindollar RH.
Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston IVF, Boston, Massachusetts, USA.
[email protected]
OBJECTIVE: To confirm that hCG levels in follicular fluid and serum would be comparable between i.m. and s.c. administration of purified hCG. DESIGN: In a prospective study, serum and follicular fluid levels of hCG after an i.m. or s.c. injection of 10,000 IU of hCG were evaluated 36 hours after injection, that is, at the time of oocyte retrieval. SETTING: This study was carried out in a university-affiliated IVF program. PATIENT(S): Forty women undergoing oocyte retrieval were entered into the study at the time of egg retrieval, that is, 36 hours after hCG administration. INTERVENTION(S): S.c. or i.m. injection of hCG. MAIN OUTCOME MEASURE(S): Serum and follicular fluid concentrations of hCG were evaluated 36 hours after injection at the time of oocyte retrieval. RESULT(S): There was a significantly higher serum hCG level in the s.c. group (348.6 +/- 98 IU/L) vs. the i.m. group (259.0 +/- 115 IU/L) and a significantly higher follicular fluid hCG level in the s.c. vs. the i.m. group (233.5 +/- 85 vs. 143.4 +/- 134 IU/L). CONCLUSION(S): After purified hCG administration via the s.c. route, both serum and follicular fluid levels are greater compared with the i.m. route.