Well I will give you the answer my doc gave me. I asked when I needed to come off? Reply, "Why would you want to come off?" There is no major problem with staying on as long as you realize there is a chance you may need to stay on a theraputic dose for the rest of your life or suffer from a low testosterone count. I am older and not interested in having kids so staying on small doses between cycles is not a big deal although I take off anyway. As far as you doing this for one cycle you will probably see little to no sides other than a longer recovery time when you do come off. I am not advocating people stay on all the time especially those in there twenties, but I think people can over dramatize the effects of this without any factual data. Any way cycle smart, get blood test done regularly, and talk with a good hormone replacement Doc. Best of luck.