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Hypothyroidism

squatpuke

New member
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Had my first ever blood-study down and I just got diagnosed with this....doc put me on a thyroid medication. Says I'll need to take this pill FOR LIFE. :(

Anyone have any experience with this?


My HDL was too high to register as my Cholestroel was 541....but he seemed to think this was all related to the thyroid.

LDL was ok at 41.


I'm pretty confused about this whole thing....bomb got dropped onto me this afternoon so I'll be Googling most of tonight.
 
Nice photo! Not to worry...or so I think. I became hypothyroid from continual cytomel use. I have taken it at very high does for 3 years and I don't know of any big issues except remembering to take it three times a day. It definately has helped me keep a low fat percentage.

Having said this, recently, I have begun accumulating fat and I can not figure out why. My training and anabolics are the same--been on them continuously under a doctors supervision for three years as well--but my body composition has been changing.

Hope this helps you.
 
The PM I was gonna send to Squatpuke was too long (LOL!!), so I am gonna post it here instead...

I will answer these questions as best as I can, and provide excerpts from medical publications since I am not yet (techically) certified to give out medical advice. I actually do know what I am talking about though.... :)
squatpuke said:
1) Take meds after waking on empty stomach about 1/2 hour before eating right?.
That is correct. It is best to take them first thing after waking and then wait a half hour to an hour or so before eating breakfast...

Taking levothyroxine with food may decrease its absorption. Levothyroxine absorption is increased when taken on an empty stomach. High-fiber diets have been shown to decrease levothyroxine absorption. Thyroid hormones should be taken an hour before eating, at the same time very day.

http://www.qfconline.com/hn/Drug/Thyroid_Hormones.htm
squatpuke said:
2) Are there any sups to NOT take after taking the dosage?
Regarding "bodybuilding" supplements, there really are none to worry about that I can think of right now... If you are concerned about something, just take it several hours after the levothyroxine. A few dietary supplements/vitamins do have potential interactions and they would be better to take a few hours after taking the levothyroxine, or around "lunch time". You can (and should!!) still take these, but just make sure they are taken several hours after the levothyroxine... It is the ABSORPTION that is the primary issue with most of these interactions, not the effects on the drugs. Once the levothyroxine is in the bloodstream, the majority of the supplements are no longer an issue and are fine to take.

Those are explained here:

Interactions with Dietary Supplements

Calcium
Thyroid hormones have been reported to increase urinary loss of calcium. However, recent research suggests that, under most circumstances, taking thyroid hormones may not be associated with reduced bone density. Calcium supplementation for people taking long-term thyroid medication has not yet been proven to be either helpful or necessary.

Simultaneous ingestion of some calcium formulations with levothyroxine has been reported to reduce the effectiveness of levothyroxine. For example, 1,200 mg per day of calcium as calcium carbonate, taken along with levothyroxine, significantly reduced absorption of the thyroid hormone. Levothyroxine activity will not be blocked if it is taken in the morning and calcium carbonate is taken after lunch and dinner. Separating these medications by at least four hours is recommended.

Iron
Iron deficiency has been reported to impair the body’s ability to make its own thyroid hormones, which could increase the need for thyroid medication. In a preliminary trial, iron supplementation given to iron-deficient women with low blood levels of thyroid hormones, partially normalized these levels. Diagnosing iron deficiency requires the help of a doctor. The body’s ability to make its own thyroid hormones is also reduced during low-calorie dieting. Iron supplementation (27 mg per day) was reported in a controlled study to help maintain normal thyroid hormone levels in obese patients despite a very low-calorie diet.

However, iron supplements may decrease absorption of thyroid hormone medications. People taking thyroid hormone medications should talk with their doctor before taking iron-containing products.

Soy
Ingestion of soy products simultaneously with thyroid hormones appears to reduce the absorption of the hormones. To be safe, people taking thyroid medication should not consume soy products within three hours of taking their medication. In addition, infants with congenital hypothyroidism given thyroid medication must not be given increased or reduced amounts of soy-based formula without consulting a pediatrician or pediatric endocrinologist.

Interactions with Herbs
Bugleweed (Lycopus virginicus, Lycopus europaeus) and lemon balm (Melissa officinalis) may interfere with the action of thyroid hormones and should not be used during treatment with thyroid hormones.

http://www.qfconline.com/hn/Drug/Thyroid_Hormones.htm

squatpuke said:
3) Are they're any sups to aid in the problem (i.e. Kelp?)

Well, this area is something I haven't looked into as much, as the medication alone seems to be working fine on its own. I ALWAYS take a good multivitamin to ensure that I am getting enough vitamins/nutrients ... I just make sure to take them later in the day so they don't effect the absorption of the levothyroxine. In order to keep this from turning into a book-length PM, I will simply give you a website that has info on lots of supplements you could take:

http://www.ithyroid.com/supplement_list.htm

squatpuke said:
4) How has the hypothyroidism affected your life, lifesytle, and lifting habits?
I, as well as most people, noticed an increase in energy levels once I got on the medication. Before the meds, I was always tired and had no motivation whatsoever, especially to go workout... After being on the levothyroxine for a while, I felt like I was back to my "old self" again... and returned to the gym in full force! My onset of hypothyroidism happened pretty drastically, so I knew something was wrong and went to the Doc pretty quickly to get it taken care of. The potential symptoms of this condition can really take its toll on someone's life, so I wanted to avoid that as much as possible.

squatpuke said:
5) My Cholesterol was WAY high...like 500+ and he said this caused my HDL to not register...my LDL was ok at like 42 or something...does this sound right. He also said that these results are probably high because of the thyroid problem and he expects them to change along with the TSH level (which was like 150 or something).
Your levels are high, but not suprising for someone with hypothyroidism. Your LDL levels look very good though, which is reassuring. I included (below) an exerpt that explains why your cholesterol levels are so high and how they got that way. Once you have been on the levothyroxine for a while, those HDL numbers should go down drastically, but still not overnight.

This is an excerpt from the American Association of Clinical Endocrinologists (AACE) press release, and I have highlighted parts that are relevant to this question:

The Thyroid-Cholesterol Connection
Cholesterol is a substance that is transported by fat-carrying proteins in the bloodstream. The body manufactures cholesterol to maintain the integrity and strength of cellular walls. However, if there is a decrease in the body's ability to metabolize cholesterol, an excess of cholesterol in the blood may occur - a condition known as hypercholesterolemia. Elevated blood cholesterol levels can lead to the formation of cholesterol deposits in the walls of the arteries, especially around the heart. These deposits can potentially block blood flow, causing heart attacks or strokes. An estimated 98 million Americans (more than half of American adults) have elevated cholesterol - a major contributor to heart disease, the leading cause of death in the United States.

The thyroid, a small, butterfly-shaped gland located below the Adam's apple, produces hormones that regulate body metabolism. If the thyroid gland is underactive (hypothyroid) and producing too little thyroid hormone, metabolism can slow, having a direct impact on the body's ability to metabolize blood cholesterol. Common symptoms of hypothyroidism include moderate weight gain, fatigue, mood swings or depression and dry skin, hair or nails. The average blood cholesterol levels of patients with underactive thyroid are often 250 mg/dL or more, which is 30 to 50 percent higher than desirable (normal range is considered under 200 mg/dL).
"Clinical experience shows that an estimated 10 percent of patients with elevated cholesterol levels have an underactive thyroid,& explains Stanley Feld, M.D., M.A.C.E., past-president of AACE. "For these patients, treatment of hypothyroidism with thyroid replacement hormone will restore the body's metabolism to normal levels and increase the ability to clear cholesterol from the blood, resulting in lower cholesterol levels and a decreased risk for heart disease."

Thyroid disease affects approximately 13 million Americans, yet more than half of these patients remain undiagnosed. In addition to hypothyroidism, thyroid disease can result from an overactive thyroid gland, a condition known as hyperthyroidism. Commons symptoms of hyperthyroidism are weight loss, insomnia, sleep disturbances, nervousness and irritability. An enlarged thyroid gland (goiter) can be a sign of either hypothyroidism or hyperthyroidism.

Once treated, these symptoms can be relieved and the patient's quality of life can be improved. Left untreated, however, thyroid disease can lead to an increased risk for heart disease, infertility and osteoporosis.

"It is important that patients learn to recognize and evaluate the subtle signs and symptoms that can be significant markers of thyroid disease," says Dr. Dickey. "Many people dismiss common feelings of fatigue or mood swings as part of normal menopause or aging when, in fact, they are symptoms of thyroid disease and can be relieved easily with treatment."

http://www.aace.com/pub/tam2000/presstam2000.php


From what you said, I will be suprised if your Doc doesn't end up raising you levothyroxine dose up a bit, depending on what your TSH levels are when you get tested again. 50mcg is the typical starter dose and they adjust it up from there, after they see how much of an impact the 50mcg has made on the TSH. The thing with levothyroxine is that it takes a while to fully "kick in"... about 4-6 weeks. You should notice a gradual increase in enegy over that time, even at that small of a dose (50mcg)...
I have used both Levoxyl and the generic levothyroxine, and there really is no difference. If you can get the generic, go for it... It will save you money!! If you have any friends that are Doctors or Pharmaceutical reps, they will quite often give you a bunch of "trial packs" of Levoxyl so you don't have to pay for anything at all....

I really hope this helps, and again, please feel free to PM me again if you have more questions. Hypothyroidiism is a complcated condition that can affect many areas of your body until the treatment is adjusted and "kicks in"... Be patient, you will feel much better when everything is back to "normal".

Good luck bro!! Let me know if you have ANY more questions.... :)
 
Hey Beefcake...couple of more questions, if you please.

I for sure am planning on switching to the generic, levothyroxine, when my 30 days of Levoxyl are up...can't afford it.

Will this have any effect on my levels at the end of my first 30 days? I wouldn't think so, but I don't want to regress...

Secondly, did you have any side-effects? I think one is insomnia and I swear I've only been getting 3 to 5 hours each time I sleep this past week or so....could be the hypothyroidism or could it be the meds? It's kicking my ass though because I'm tired as hell but when I lay down but just can't get to sleep...if I sit up (like at work) I can't stay awake...

I've had like a combined 8 hours of sleep in the past 3 days...


My last gripe is that I've never been hand-cuffed to a pill bottle before...that is, taking a pill every day at same time....how critical is it with this drug. For instance, I drove to my night classes (30 minutes away) then remembered I forgot the pill...drove all the way home (30 minutes) and then BACK to work (another 30 minutes)...I was quite cranked with gas being $2.90 here....let alone the time I wasted....do you keep spare pills in your car/gym bag/work...for such instances? Can heat or shelf life kill the effectivess of this hormone?

Thanks.
 
squatpuke said:
Hey Beefcake...couple of more questions, if you please.

I for sure am planning on switching to the generic, levothyroxine, when my 30 days of Levoxyl are up...can't afford it.

Will this have any effect on my levels at the end of my first 30 days? I wouldn't think so, but I don't want to regress...

Assuming that the doses are the same, nothing will change when switching from Levoxyl to generic... Exact same drug, exact same dosage. All you are paying extra for with the Levoxyl is the brand name. Websites will always tell you to "check with your doctor or pharmacist before switching from brand name to generic", but that really is a unnecessary. Often times the generic seem to work better than the brand name, IMO.

Remember, it will take 1 to 2 months for the full metabolic effects of this drug to kick in... Switching from brand name to generic will not affect that as long as they are the same drug and dosage.

squatpuke said:
Secondly, did you have any side-effects? I think one is insomnia and I swear I've only been getting 3 to 5 hours each time I sleep this past week or so....could be the hypothyroidism or could it be the meds? It's kicking my ass though because I'm tired as hell but when I lay down but just can't get to sleep...if I sit up (like at work) I can't stay awake...

I've had like a combined 8 hours of sleep in the past 3 days...
I'm guessing it is the levothyroxine, based on your experience forgetting it on the way to night classes... It is very important to take levothyroxine first thing in the morning (or upon waking, whatever time that is), or else it will cause insomnia...

"How should I take levothyroxine?
• Take each dose with a full glass (8 ounces) of water.
• Take this medication at the same time each day whenever possible. Thyroid hormone is usually taken in the morning to prevent insomnia at night. Follow your doctor's instructions.
• Do not stop taking this medication for any reason without talking to your doctor first. It may take several weeks for you to start feeling better. Once you start feeling all right, do not stop taking levothyroxine. You will probably need to take this medicine for the rest of your life.
• Store levothyroxine at room temperature away from moisture and heat.

What are the possible side effects of levothyroxine?
• If you experience any of the following serious side effects, stop taking levothyroxine and seek emergency medical attention:
· an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
· vomiting; or
· chest pain, irregular heartbeat, shortness of breath.
• Other, less serious side effects may be more likely to occur. Continue to take levothyroxine and talk to your doctor or try another similar medication if you experience
· tremor, nervousness, or irritability;
· headache;
· insomnia;
· diarrhea, changes in appetite, or weight loss;
· leg cramps;
· menstrual irregularities; or
· fever, sweating, or heat sensitivity.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome."

http://www.drugs.com/levothyroxine.html

squatpuke said:
My last gripe is that I've never been hand-cuffed to a pill bottle before...that is, taking a pill every day at same time....how critical is it with this drug. For instance, I drove to my night classes (30 minutes away) then remembered I forgot the pill...drove all the way home (30 minutes) and then BACK to work (another 30 minutes)...I was quite cranked with gas being $2.90 here....let alone the time I wasted....do you keep spare pills in your car/gym bag/work...for such instances? Can heat or shelf life kill the effectivess of this hormone?

Thanks.

It isn't life or death... If you forget a dose, just take it as soon as you can within reason. There are many times throughout the week that the time I take it varies, depending on when I am working, at school, etc.... It can vary up to several hours depending on the day. It isn't that big of a deal... My general rule is that I just take it first thing upon waking. This also alleviates the issue with insomnia....

"What happens if I miss a dose?
• Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication."

http://www.drugs.com/levothyroxine.html

As far as storage, I keep mine at home since I just take it first thing in the morning, so I don't have to worry about it for the rest of the day... If you take it somewhere with you, heat can damage the pills and make them less effective.

The shelf life is a touchy issue... The general rule is that you should never take drugs after they expire. Realistically, the only thing that happens (usually) is that after the shelf life, the drug starts to break down, slightly reducing its potency. The longer past the shelf life you go, the less potent the medication becomes... I am not going to say "go ahead and take them after they expire", but if they are just a little outdated, I would probably take them... but that is your decision to make.

"Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom)."

http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682461.html

I hope this helps... Let me know if you have any more questions or if I didn't fully answer a question that you have alread asked.... :)
 
One more question for good measure...


How the hell did I get hypothyroidism?

Thought I heard or read somewhere that you can aquire this by crash-dieting...althought I would presume it's my Type A, hyper-stress life.
 
squatpuke said:
One more question for good measure...


How the hell did I get hypothyroidism?

Thought I heard or read somewhere that you can aquire this by crash-dieting...althought I would presume it's my Type A, hyper-stress life.

The causes are so numberous that it would be impossible for me to pinpoint how it developed, especially without knowing your medical history. In my case... I believe it is genetic, as my mother and grandfather both have it... and several aunts, uncles, and my brother are strong suspects, but that is not known for sure.

Here is a general list of causes for adult clinical hypothyroid, although it does not include everything:

Causes: Hypothyroidism commonly manifests as a slowing in physical and mental activity. Hypothyroidism has many causes. The 2 most common are autoimmune thyroid disease and previous treatment of hyperthyroidism. Causes can also be classified based on the location of the main dysfunction, such as primary, secondary, or tertiary, or whether the condition is congenital or acquired.

The most frequent cause of acquired hypothyroidism is autoimmune thyroiditis (Hashimoto thyroiditis).
The body recognizes the thyroid antigens as foreign, and a chronic immune reaction ensues, causing progressive destruction of functional thyroid tissue.
Various serum thyroid antibodies are positive in 95% of patients; however, the antibodies may not be detectable early in the disease process.
Use of radioactive iodine for Graves disease and nontoxic goiter may cause permanent hypothyroidism.
A transient form of hypothyroidism can occur in the postpartum period or can result from subacute thyroiditis or silent thyroiditis.
Causes can also be divided into disorders causing loss of functional tissue or disorders of defective synthesis. Traditionally, causes are classified based on location of the disorder, ie, in the thyroid (primary) or in the pituitary and/or hypothalamus (secondary and/or tertiary).

Primary hypothyroidism

-Functional

-Chronic autoimmune thyroiditis

-Silent or subacute thyroiditis

-Radioiodine therapy

-Postoperative hypothyroidism

-Infiltrative disease of the thyroid

-External irradiation to neck

Defects in thyroglobulin or thyroid hormone synthesis

-Cretinism

-Defects of synthesis

-Congenital

-Iodine deficiency

-Iodine excess

-Antithyroid agents

Secondary and/or tertiary hypothyroidism

-Pituitary hypothyroidism

-Hypothalamic hypothyroidism

-Generalized resistance to thyroid hormone

-Drugs (including dopamine, amiodarone, lithium)

http://www.emedicine.com/MED/topic1145.htm

My guess (STRONG emphasis on "guess"!!) would be something in the "Secondary and/or tertiary hypothyroidism" category, if you have none of the other causes or it is not known to be genetic. Most all of the causes in that category could be directly/indirectly induced by stress and/or lifestyle factors, as you described.
 
Beefcake, I was recently diagnosed borderline hypothyroid. My naturopath put me on naturethroid. Its a natural thyroid pill. Seems to work pretty well. BUt lately I have been super tired. I was feeling good for a while but slowly increased my dose and now all of a sudden for like a week I have been super tired. I dont know if its the thyroid shit or my diet because I was cycling carbs. So tomorrow I am having complex carbs and will see what happens.

Squatpuke, did you have insomnia before taking your med?
 
I'm not sure if it was "insomnia" per se, or just stress....

Because of my weight, I think I also have sleep apnea...that is, my wife said that I have stopped breathing while we "cuddled" one time.

Last week, I didn't sleep for 38 hours straight....finally was able to crash for 8 solid. Then 7 the next night....now it's back to weekdays and I'm messed up again....I think I had this problem PRIOR to the levoxyl....

Doc says if I lose a few pounds it will significantly help....


As well, I work nights and get off at 6:am.....then go to school (on my 2nd degree) with one class at 10:30am (MW) then another class (TTH) at 5:30pm....

So my schedule and stress levels are quite f**ked up.....(excuse me)


Beefcake....I'm interested in playmates' naturethroid....is there a big difference in all these thyroid meds? Currently, mine cost 18 bucks...I can go generic for 15...not much savings....is there any difference in performance? Isn't the most popular one synthyroid? Does it have a generic...should it be more/less expensive?

Thanks you guys.
 
Beefcake has given some great answers on the hypothyroidism issues.

Regarding obstructive sleep apnea (an area that I did research in during medical school), even thin individuals can have this. It's more prone in those who are overweight, but as I stated earlier, it can occur in thin individuals. There seems to be a slight genetic component as well.

ANY INDIVIDUAL can develop "temporary" OSA when one is extremely tired or has had a few drinks prior to going to sleep. So if you sleep intoxicated or if you're extremely tired, you're more prone to developing OSA.

If you only slept 8 hours in 3 days, then I would think you would experience some degree of OSA. If you do this all the time, then there's a problem.

If it continues, I would ask your doctor to refer you to a sleep specialist for a sleep study. They're expensive, so you'll need insurance to cover for it. Treating OSA is important because it will make you feel rested in the morning and lessen your chances of developing some serious consequences of OSA. Some things to worry about include pulmonary hypertension, congestive heart failure, strokes, heart attacks, and many other ailments.

By the way, there are two causes of sleep apnea: peripheral (obstructive) and central (neurologic). Central sleep apnea is thought to be the reason why many people in otherwise ok (but not great) health die in their sleep.
 
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