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Hope this helps everyone!!! ^^^^^^^^
HRT for women?
- Thread starter Smokescreen
- Start date
K to you brother
Its all good bro!!
It has nothing to do with conversion. AI's weren't invented to stop aromatization from testosterone, but they do -- that's why bodybuilders use them. Breast cancer is exasperated by estro, which is why women use nolva.
XMAN.
New member
Anastrozole
From Wikipedia, the free encyclopedia
Anastrozole (INN, trade name Arimidex, AstraZeneca) is a drug used to treat breast cancer after surgery and for metastases in post-menopausal women.
Anastrozole is an aromatase inhibitor, which means that it interrupts a critical step in the body's synthesis of estrogen. Some breast cancer cells require estrogen to grow, and eliminating estrogen suppresses their growth.
Annual sales approx $2.2bn. Patent expires 2010 in the US[1]; however, the generic form is available in some other markets.
Clinical trials
The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial was an international randomised controlled trial of 9366 women with localizedbreast cancer who received either anastrozole, tamoxifen, or both for five years, followed by five years of follow-up.[2] After more than 5 years the group that received anastrozole had significantly better clinical results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer that isestrogen receptor (ER) positive.
Another study found that the risk of recurrence was reduced 40% (with some risk of bone fracture) and that ER negative patients also benefited from switching to Arimidex.[3]
Mechanism of Action
Anastrozole inhibits the enzyme aromatase, which is responsible for convertingandrogens to estrogens. Anastrozole binds reversibly to the aromatase enzyme through competitive inhibition.
Elevated levels of estrogens may increase the severity of breast cancer, as sex hormones can cause hyperplasia and differentiation at estrogen receptor sites.
Side effects
Bone weakness : Women who switched to Arimidex (after two years on tamoxifen) reported twice as many fractures as those who continued to take tamoxifen (2.1% compared to 1%).[3]
Bisphosphonates are sometimes prescribed to prevent the osteoporosis induced by aromatase inhibitors but have another serious side effect, osteonecrosis of the jaws. Since statins have a bone strengthening effect [4], combining a statin with an aromatase inhibitor may avoid both fractures and possible cardiovascular risks [5]without jaw osteonecrosis.[6] In one study of women with breast cancer takinganastrozole, statin use was associated with a 38% reduced fracture risk, or approximately the equivalent of 10 mg Fosamax daily.
Anastrozole - Wikipedia, the free encyclopedia
XMAN.
New member
what i wanted to say nelson is that if anastrozole is better than tamoxifen (nolva) in reducing estrogen by binding to the aromataze enzyme then there has to be a high amount of testosterone converted to estrogen in the first place , and u said b4 to carth that women don't have an HPTA so they don't convert test to estrogen and they only produce estro from the ovaries.
You keep talking about conversion. Women don't get excess estrogen from testosterone aromatizing into estrogen. I'm not sure where you're getting that from that information. Maybe I'm misunderstanding you.
I think we are all now like...."WTF?"
Nelson, explain to me how my wives estrogen, progesterone and testosterone levels dropped to almost nothing while on 6.25mgs of Proviron for 4 weeks? If "women" don't have an HPTA. She told her doc she was going to take the DHT drug. Doc told her that her body will sense the high DHT. And will then "stop" producing lots of hormones. And that's EXACTLY what happened.
Nelson, explain to me how my wives estrogen, progesterone and testosterone levels dropped to almost nothing while on 6.25mgs of Proviron for 4 weeks? If "women" don't have an HPTA. She told her doc she was going to take the DHT drug. Doc told her that her body will sense the high DHT. And will then "stop" producing lots of hormones. And that's EXACTLY what happened.
From what I always knew. Women created testosterone from the ovaries and adrenals. And got their estrogen due to the EXTREME high rate of aromatization their bodies does. Hence why anti-aromas are used for women to slow down the excess creation of estrogen. And hence slow down cancer created from estrogen.
That has nothing to do with what we're talking about. I "thought" the subject was women producing e from excess T, which is not the case.
I sense a little antagonism bro. Chill.
I can help explain, if you like, what happened with the Proviron, but not right now. Gotta run. Catch you on the rebound.
