I found it completely useless.
I did benifit a great deal from 5-HTP though. Even used 5-HTP and NADH at one point.
I have never truely been clinically depressed though, just "dysthymic" (ie: general maliase, sadness, etc). I found the cobo of the above two to be VERY helpful in dealing with my "stupidity" too (ie: I took E a few times and the depression that can cause is severe, 5-HTP/NADH makes that not happen at all...)