GH... best every day or EOD?

[Outtlaw]

Outlaw, this is NOT doubling the dosage! 8iu every OTHER day is the exact same dosage as 4iu/ed. Both yeild 4iu/day. The question was, which is more effective, 8iu/eod or 4iu/ed? The studies I've read suggest that 8iu/eod is better then 4iu/ed. Wanted EF guys opinions on that. Also, I assume the 8iu's would still be divided up, 4iu's in the am, 4iu's in the PM? Anyone have experience running both? Differences, preferences? K to all who help when I can give it, thanks!

Yes it is doubling the dose. 4iu doubled equals 8. I understand that you're thinking in terms of total weekly dosage, but as I said before, that is NOT how you do a comparative study. When doctors do studies on gh they often do EOD and ED comparisons, but they dont double the dose on the alternate day group.

 

[Outtlaw]

Exactly, 8 IUs ED versus 8 IUs EOD will yeild more significant results, regardless of the additional side effects (edema in particular). The EOD dosing schedule does seem to have an advantage over ED when based upon the same total weekly dosage, but this is not necessarily the case when comparing different weekly totals. Insulin usage is mandatory with a higher dosage and ED dosing schedule in order to maximize the results.

Jenetic

Agreed.

 

[Outtlaw]

Tux, so you can learn something... This is how you do a "real" study on the effectivness of ED vs EOD dosing. This is just an excerpt of the study, but as you can see nothing is doubled. Both groups are given 6mg or 18iu of gh.


Research into human growth hormone to treat fat and metabolic changes


Moyle presented a randomised, double-blind study of 757 people with AIDS wasting who were randomised to one of three arms: 6mg recombinant human growth hormone (r-HGH) daily; 6mg r-HGH on alternative days, or placebo. Evaluation of 555 people taking antiretroviral therapy who completed 12 weeks of treatment showed r-HGH was effective in increasing lean body mass, improving physical performance and improving quality of life in HIV-positive people with AIDS wasting. Average increase in lean body mass was 5.21kg in the daily treatment group and 3.33kg in the alternate group (both p<0.001). Total body mass by DXA scan fell by -1.41kg in the daily treatment group and by -1.23kg in the alternate group (p<0.001). Similarly, total trunk mass also fell significantly in the two treatment groups, by -1.04kg and -0.80kg. Overall weight increased by about 3kg in the daily group and 2kg in the alternate group. Approximately 20-30% of r-HGH recipients experienced joint and muscle pain while fluid retention occurred among a third of people receiving daily treatment. Serious side-effects associated with r-HGH included skin cancers, Buerger's disease (inflammation of the arteries usually associated with smoking which can lead to pain and gangrene of the limb), development of breasts in men, and gastrointestinal bleeding.

 

[informed09]

Yes it is doubling the dose. 4iu doubled equals 8. I understand that you're thinking in terms of total weekly dosage, but as I said before, that is NOT how you do a comparative study. When doctors do studies on gh they often do EOD and ED comparisons, but they dont double the dose on the alternate day group.

are you saying that the 8iu EOD would yeild better results than the 4iu ED even though it is about the same weekly dosage?

 

[Outtlaw]

are you saying that the 8iu EOD would yeild better results than the 4iu ED even though it is about the same weekly dosage?

Yes I think the results would be better, but by how much I cant say. And since people dont do scientific studies by giving people different doses, who could say for sure. But I dont know why anyone would want to do 4iu of gh in the 1st place. I think you'd be better off putting your money elswhere.

 

[Tux]

Outlaw, I'm still not getting something. That study proved NOTHING. It said you get BETTER results doing 6mg ED instead of 6mg eod, which is HALF the dosage. So obviously if I did 4iu/day vs 4iu/eod I'd get fewer results on the eod b/c total weekly dosage is only half. I asked if you took 4iu/day or 8iu/eod, the SAME weekly dosage, which yeilds better results. Find me a study on that and I'll attach some possible validity to it, the study you posted gives me nothing I didn't know already. Still I gave you K for the research

 

[Outtlaw]

That's the problem, I've never seen a study that's done like that. They always normally keep the doses the same. We can only speculate on what the results would be. It's quite obvious that 8iu EOD will yeild better results than 4iu ED, but by how much I dont know. I highly doubt the results at 8iu EOD would be double that of 4iu/day, but I believe they will be somewhat better.

 

[informed09]

That's the problem, I've never seen a study that's done like that. They always normally keep the doses the same. We can only speculate on what the results would be. It's quite obvious that 8iu EOD will yeild better results than 4iu ED, but by how much I dont know. I highly doubt the results at 8iu EOD would be double that of 4iu/day, but I believe they will be somewhat better.

Better for loosing fat or gaing mass, or both? If you are running GH at low doses(4iu) isnt it geared more towards loosing fat?

 

[Outtlaw]

Better for loosing fat or gaing mass, or both? If you are running GH at low doses(4iu) isnt it geared more towards loosing fat?

I guess that depends on who you ask. I dont run gh for fat burning purposes (I think there are better options for that). If I had to guess, I'd say that overall results (mass gains and lipolysis) at 8iu EOD would probably be around 20% better than 4iu/day.

 

[Tux]

Guess next time I run GH, I'll try 8iu/eod instead of 4iu/ed and see what happens. At least this way I only have to do sub-q injects eod... not that those hurt a single bit, but meh