The theory is that steady state concentration (and therapeutic effect) will be reached faster. But this doesnt work for anabolic androgenic steroids. Why? BC steady state concentration is usually achieved after four half lives. The half life for long esters is days and weeks.
Assuming T1/2 of TestEnanthate is 10 days, then it won't be reached until 40 days. Also, of the several recognized pathways of action, the MAIN one we are interested in, the anabolic component of protein synthesis (transcrption/translation, etc.) takes a good two weeks to occur. No amount of loading dose is going to increase the speed of this process.
The loading dose = the volume of distribution x the desired concentration (i.e. the concentration at steady state).
If you run the numbers for a 500mg weekly dose:
Loading dose = usual maintenance dose / usual dosage interval x kel (t1/2/0.693). This comes out to about 1 gm.
But as explained above, you will get all the risk and none of the benefits.
It does work for faster acting compounds however, thus you may frontload with single esters or orals.
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