The one problem that all these places have is that they are selling you a mixture of r and s ALA. These mixtures are not 50-50 and they don't have to tell you how much r (which is the one that works) you are actually getting. So if you find that your results and sides vary from batch to batch that's why. All of the research done was done with the r and all the research done with the s was very disappointing. Thus the s is very cheap and used as almost a filler in the cap with the r in terms of what you need it for.