Oh sweet! Lyle has checked on this info and I want to say thanks to you. Mischief, and Lyle. I just had a crazy thought one night and put bromo and DNP both together and thought up of the possible strategies of how it can enhance fat loss.
Of course, Im bound to screw up since I am far from a guru and barely know some physiology. Let me answer some of Lyle's input.
"**LYLE: This part is wrong/irrelevant. Leptin isn't produced by the liver or pancreas so affecting mitochondria through uncoupling there is irrelevant. And DNP doesn't relaly affect fat cells. So what he 'personally thinks' happens to be completely wrong.**"
As you can see, my knowledge of physiology is shit. THe reason I thought of this was simply thinking of the refeeding-leptin enhancing aspects.
For example, I thought if insulin levels were plumetted due to low ATP levels in the pancreas, then how would glucose reach to the fat cell without insulin? Doesn't that hold some responsibility for the upregulation of leptin pushing carbs into fat cells? I just figured if we tried to raise leptin levels up through a refeed on DNP, it would be a tough thing to do.
And Lyle is of course right about DNP not affecting fat cells, which is why putting Usnic Acid or some other uncoupler into a topical cream is a complete waste of time since hardly any of it will reach the mithochondria lacking fat cell (although there may be traces, but I would like to be corrected if wrong). Practically most of the mitochondria will be affected within the muscle cells, so taking it orally and getting the systemic effect would work just fine.
"**LYLE: Yes, but no different than any other drug. Any time you pull calories out of fat cells (DNP, EC, dieting, whatever) leptin drops.** "
I was just thinking the profound effects of DNP pulling calories out of fat cells faster than EC, thyroid, etc so that's how I came up with that reasoning of thinking with the drop of leptin. Im just speaking of a time issue here. No different if we lost a 2 lbs of bodyfat within 7 days from DNP or diet or whatever it may be, but I figured if people 'tend' to lose body fat faster on DNP than most other ways, then leptin would go down faster.
"**LYLE: Yes. INitially, DNP adds to the normal metabolism. After a while, it is replacement only. Same with EC. EC doesn't 'stop working', the body has shut down metabolic rate so that eC is now only a replacement of what's missing.**"
Lyle makes an excellent point where which I noticed hardly anyone else didn't think of once they ceased DNP. That is our own body's metabolism shuts down while using a 'replacement' like DNP and we are more susceptible to gain more fat due to a shitty metabolism once we finish the cycle.
This is why skinfold calipers are out there folks. They are used to measure bodyfat, so let's learn and start using them.
"**LYLE: Not sure if this follows. DNP is working through such a distinctly different mechanism than everything else.
That is, EC works through the sympathetic nervous system. With dieting, SNS activity goes down, bromo corrects that.
DNP is uncoupling mitochondrial metabolism, which isn't affected (for the most part) by dieting. NOt sure you can use a lower dose.**"
I went into a simple mode of thinking here. I just figured if leptin levels are maintaned better our or brain is fooled into thinking our bodies are not starving to death, other hormones which may have some interrelations with DNP may go up or be better balanced. For example T3 may stay higher than usual, and while I have no proof of this, the longer one stays on DNP the more critical T3 becomes. I could be wrong on this though. And there are the other hormones like GH, etc, etc.
And how I thought up of a lower dose DNP was simply meaning that we may not have to be as dependant on DNP for fat loss then before since our brain-bodies are now better adjusted for the environment with bromo.
"**LYLE: If there is any effect of DNP on DA, it'll be indirect, by lowering leptin. The mechanism of DNP just doesn't give it any other way to affect DA levels.**
And this is what I figured. But now I know for sure thanks to Lyle.
"**LYLE: You sound like me: the stress and anger approach to fat loss. **"
Some guys go to bars to start fights, others scribble in their diary and leave it locked inside when it comes to dealing with some anger issues. I figured it would make more sense to take it out on my body fat since this is the fight that actually has any meaning to me. WWWIII up in this body here.
In closing, if anyone else wants to reap any benefit on this issue, just skip my writings and focus on Lyle's. Im being honest here, he is that right on with this stuff. Also, his booklet covers tons of stuff with bromo and leptin which is very intriguing.
Mischief, if Lyle can read this again, I would be a blushing poster.
Thanks.
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so we'll see how it goes. Updates to follow, wish me luck
