DNP and rashes

[DangerMouse]

I just came off of my third DNP cycle, and with some ball bustin’ weight training and cardio I managed to loose 17 lbs. Cool! I noticed a few days ago a rash on my arms, which I thought was just really dry skin at first, but it got worse and covered my whole body eventually. I’ve had a heat rash before but it was only on parts of my body that were exposed to the sun (arms/legs). This is weird. I haven’t seen any DNP post from any of you guys experiencing anything like this, but let me know if you got any ideas. Hopefully its just and allergic reaction.

 

[HUCKLEBERRY FINNaplex]

Look at my DNP post...I had the exact same response...It's an allergic reaction to histamines influenced by DNP...Benadryl will counter it in the early stages,but once your skin dries out like that(as mine did)moisturizing lotions will help keep your skin hydrated...

 

[macrophage69alpha]

TRY QUERCETIN- IT INHIBITS GRANULATION AND RELEASE OF HISTAMINES.

 

[HUCKLEBERRY FINNaplex]

Is that OTC macro?

 

[macrophage69alpha]

YES IT IS.

IT IS A HERBAL EXTRACT.

 

[HUCKLEBERRY FINNaplex]

How would you compare it to Benadryl in terms of combating hives?

 

[macrophage69alpha]

It should stop you from getting them in the first place.
I have bunch of info somewhere, let me see if I can dig it back up.

peace

 

[WannaImpress]

My last cycle..........

On my last cycle of DNP I got a bad rash all over my elbow area. Man it was disgusting but the weird thing about it is that I got it at the end of my cycle, I knew that was it because I recently started another one and the rashes started within two days but I was able to apply some caladryl before it started to be to visible! All in all, I'll still do some more DNP!

 

[wuberton]

hey,
im doin 600mg/day, and I was just wondering if anyone else noticed muscle soreness. after workouts, i tend to stay sore longer, and just experience more muscle soreness....any advice?
later

 

[bigrand]

Macro,

Do you think that stuff will have an effect on me, as to where i will be able to take DNP again?

 

[macrophage69alpha]

it is possible.
the use of a combination
of
quercetin
and
olive and or artichoke leaf extract
which is high in luteolin
may be sufficient to inhibit the release of histamines
additionally while searching it seems that DNP and the atp depletion that it induces directly causes this histamine response.

this study used rotenone- which while SLIGHTLY different in its action than DNP- results in similar depletion of ATP.


Protein phosphatase inhibitors and heat preconditioning prevent Hsp27 dephosphorylation, F-actin disruption and deterioration of morphology in ATP-depleted endothelial cells.

Loktionova SA, Kabakov AE.

Cardiology Research Center, Moscow, Russia.

The vascular endothelium response to ischemic depletion of ATP was studied in vitro. Endothelial cells (EC) cultured from human aorta or umbilical vein were incubated in a glucose-free medium containing CCCP or rotenone. Such blockade of energy metabolism caused a drop in ATP, destruction of actin filaments, morphological changes, and eventually disintegration of EC monolayer within 2-2.5 h. While ATP fell and F-actin collapsed, the 27-kDa heat shock protein (Hsp27) lost basal phosphorylation and became Triton X-100-insoluble forming granules inside the cell nuclei. Protein phosphatase (PP) inhibitors (okadaic acid, cantharidin, sodium orthovanadate) did not delay the ATP decrease in energy-deprived EC but arrested both the alterations in the Hsp27 status and the changes for the worse in F-actin and cell morphology. Similarly, the Hsp27 dephosphorylation/insolubilization/granulation and the cytoskeletal and morphological disturbances resulting from lack of ATP were suppressed in heat-preconditioned (thermotolerant) cultures, this effect being sensitive to quercetin, a blocker of Hsp induction. The longer preservation of the cytosolic pool of phosphorylated Hsp27 during ATP depletion in the PP inhibitor-treated or thermotolerant EC correlated with the acquired resistance of F-actin and morphology. These data suggest that PP inhibitors as well as heat-inducible Hsp(s) can protect ischemia-stressed cells by preventing the ATP loss-provoked protein dephosphorylation and breakdown of the actin cytoskeleton.

This certainly needs more than cursory evalution, so look it over- AS I WILL.

peace

 

[TxLonghorn]

Damn macro, you sure impress the hell outta me, lol. You root around perusing clinical studies and I sit here and say things like, 'Dnp burn fat. Burn fat goooood.'

I am glad I don't seem to have any reaction with dnp, other than it really doesn't seem to like my bodyfat.

 

[HUCKLEBERRY FINNaplex]

I agree TX this man comes up with stuff that NO ONE knows,and it's always terrific,highly usefull information...

Macro,would you know where one would most likely be able to find these OTC,and what kind of dosage would you recommend for the desired purpose of inhibiting histamic reactions?Lastly,do you think it would reduce DNP's efficiency of fat reduction(by interference of the ATP conversion process)?

 

[HUCKLEBERRY FINNaplex]

Damn,this is already on the second page?!?LOL...

 

[HUCKLEBERRY FINNaplex]

One last shamefull bump before I take off for work...Dr.Macro,I need your prescription on dosages,lol...

 

[macrophage69alpha]

Dosages????
Start with 2-3 times the reccomended. Most health food stores will carry the quercetin and olive leaf (DPS has them too)- the artichoke leaf extract may be harder to find.

If you want some quercetin powder, E mail me- Still have a KILO of it- it goes pretty slowly.

BTW- a side note quercetin inhibits aromatase (though only slightly)

 

[HUCKLEBERRY FINNaplex]

Sincere thanks macro...You are terrific.

 

[Fonz]

Hey Macro, just got 1 Kg of Quercetn from
Kilosports(Damn I LOVE that store.......LOL),
and I'm starting my 50-day bridging phase with
DNP at 200mgs/day/Anavar/Liquidex/Clomid. Just
wondering how much quercetin to take?

Just for the record, is quercetin a broad-spectrum histamine
antagonist or is it an H1 or H2 antagonist?

Couldn't find any info on the matter.

I've used ketotifen in the past(better than benadryl) but just
ran out, so I thought I'd give Quercetin a try.

Fonz

 

[christof]

Hey macro, I'm glad I foud this post. It is pure luck really, I'm just sat here late on a Saturday night messing around, but this helps me alot.

You see for the last 2 weeks I've had this rash all over my body, a bit like a nettle sting rash, or heat rash. Any how it was 2 weeks ago I finnished my 3rd DNP cycle prematurely because of this rash, I foolshly thought that it was an allergic reaction to the ECA I had just introduced to the cycle for the first time, which after reading this thread it seems more likely to be a reaction to DNP.

It's strange because after 2 weeks I still get the rash, and it seems to have made my skin really delicate, i.e. if I get an itch and I scratch it, I develop a severe rash where I had the itch, but then after about 10 mins or so it goes away.

It's just worrying that I still have this reaction nearly 2 weeks on.

I may now go out and get some QUERCETIN in the hope that it will help clear this up.

If you have any more ideas or thoughts on this I hope you will post a reply.

 

[Ceebs]

Liver-supportive supplements such as milk thistle and licorice root will also help your rash. I did a couple cycles of DNP last year, no rash on the first one, but broke out badly on the second cycle, and I swear within hours of popping a few milk thistles, the rash cleared up. Dermatitis is actually pretty common on Da Nasty Poison - you could get down with some oatmeal lotion (mind out of the gutter) like Aveeno to sooth your skin, in addition to supplementing with Benadryl and herbs.

Just my $0.01. Good luck on your cycle.

 

[MJay95]

TRY QUERCETIN- IT INHIBITS GRANULATION AND RELEASE OF HISTAMINES.

I know this thread is VERY VERY OLD however would Quercetin work for other types of allergic reactions (for example EQ)

Thanks Macro!

MJay95