The soy debate is far from over, but men who are worried about
consuming soy foods might find these snippets interesting
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From:
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=11303585
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1: Cancer Epidemiol Biomarkers Prev. 2001 Mar;10(3):179-84. Related Articles, Links
Erratum in:
* Cancer Epidemiol Biomarkers Prev 2001 Sep;10(9):1013.
Effect of soymilk consumption on serum estrogen and androgen concentrations in Japanese men.
Nagata C, Takatsuka N, Shimizu H, Hayashi H, Akamatsu T, Murase K.
Department of Public Health, Gifu University School of Medicine, Japan.
Soy consumption has been associated with a reduced risk of prostate cancer. The mechanism for this association may involve the effect of soy on the endocrine system. We conducted a randomized dietary intervention study to determine the effects of soy consumption on serum levels of steroid hormones in men. Thirty-five men were randomly assigned to either a soymilk-supplemented group or a control group. The men in the soy-supplemented group were asked to consume 400 ml of soymilk daily for 8 weeks. The men in the control group maintained their usual diet. Blood samples were obtained just before the initiation of the dietary period and thereafter every two weeks for 12 weeks. Changes in hormone concentrations were analyzed and compared between the two groups using the mixed linear regression model against weeks from the start of the dietary period. The mean (SD) soymilk intake estimated from dietary records during the dietary study period was 342.9 (SD, 74.2) ml in the soymilk-supplemented group. There was a significant difference between the two groups in terms of changes in serum estrone concentrations, which tended to decrease in the soy-supplemented group and increase in the control group over time. None of the other hormones measured (estradiol, total and free-testosterone, or sex hormone-binding globulin) showed any statistical difference between the two groups in terms of patterns of change. The results of the study indicate that soymilk consumption may modify circulating estrone concentrations in men.
Publication Types:
* Clinical Trial
* Randomized Controlled Trial
PMID: 11303585 [PubMed - indexed for MEDLINE]
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From:
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=11880595
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1: J Nutr. 2002 Mar;132(3):570S-573S. Related Articles, Links
Hormonal effects of soy in premenopausal women and men.
Kurzer MS.
Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.
[email protected]
Over the past few years, there has been increasing interest in the possible hormonal effects of soy and soy isoflavone consumption in both women and men. Soy consumption has been suggested to exert potentially cancer-preventive effects in premenopausal women, such as increased menstrual cycle length and sex hormone-binding globulin levels and decreased estrogen levels. There has been some concern that consumption of phytoestrogens might exert adverse effects on men's fertility, such as lowered testosterone levels and semen quality. The studies in women have provided modest support for beneficial effects. One cross-sectional study showed serum estrogens to be inversely associated with soy intake. Seven soy intervention studies controlled for phase of menstrual cycle. These studies provided 32-200 mg/d of isoflavones and generally showed decreased midcycle plasma gonadotropins and trends toward increased menstrual cycle length and decreased blood concentrations of estradiol, progesterone and sex hormone-binding globulin. A few studies also showed decreased urinary estrogens and increased ratios of urinary 2-(OH) to 16alpha-(OH) and 2-(OH) to 4-(OH) estrogens. Soy and isoflavone consumption does not seem to affect the endometrium in premenopausal women, although there have been weak estrogenic effects reported in the breast. Thus, studies in women have mostly been consistent with beneficial effects, although the magnitude of the effects is quite small and of uncertain significance. Only three intervention studies reported hormonal effects of soy isoflavones in men. These recent studies in men consuming soyfoods or supplements containing 40--70 mg/d of soy isoflavones showed few effects on plasma hormones or semen quality. These data do not support concerns about effects on reproductive hormones and semen quality.
Publication Types:
* Review
* Review, Tutorial
PMID: 11880595 [PubMed - indexed for MEDLINE]
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From:
http://www.ncbi.nlm.nih.gov/entrez/q..._uids=12094627
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1: Nutr Cancer. 2001;41(1-2):41-6. Related Articles, Links
Soy milk intake in relation to serum sex hormone levels in British men.
Allen NE, Appleby PN, Davey GK, Key TJ.
Cancer Research UK Epidemiology Unit, University of Oxford, Oxford OX2 6HE, UK.
[email protected]
Soy beans contain high levels of the isoflavones genistein and daidzein and their glycosides and have been implicated in the prevention of prostate cancer, possibly via their effects on sex hormone metabolism. The aim of this study was to assess the relation between dietary soy intake and sex hormone levels in a cross-sectional analysis of 696 men with a wide range of soy intakes. Soy milk intake was measured using a validated semiquantitative food frequency questionnaire, and serum hormone concentrations were measured by immunoassay. Multiple regression was used to investigate the association between soy milk intake, an index of isoflavone intake, and hormone levels after adjustment for pertinent confounders. Soy milk intake was not associated with serum concentrations of testosterone, free testosterone, androstanediol glucuronide, sex hormone-binding globulin, or luteinizing hormone. These results suggest that soy milk intake, as a marker of isoflavone intake, is not associated with serum sex hormone concentrations among free-living Western men.
PMID: 12094627 [PubMed - indexed for MEDLINE]